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1ufj

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[[Image:1ufj.gif|left|200px]]
[[Image:1ufj.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1ufj", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CZM:&#39;N,N&#39;-BIS-(2-HYDROXY-3-METHYL-BENZYLIDENE)-BENZENE-1,2-DIAMINE&#39;'>CZM</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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{{STRUCTURE_1ufj| PDB=1ufj | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ufj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ufj OCA], [http://www.ebi.ac.uk/pdbsum/1ufj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ufj RCSB]</span>
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'''Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin'''
'''Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin'''
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[[Category: Watanabe, Y.]]
[[Category: Watanabe, Y.]]
[[Category: Yamane, T.]]
[[Category: Yamane, T.]]
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[[Category: iron]]
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[[Category: Iron]]
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[[Category: metalloprotein]]
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[[Category: Metalloprotein]]
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[[Category: myoglobin]]
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[[Category: Myoglobin]]
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[[Category: salophen]]
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[[Category: Salophen]]
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[[Category: schiff base]]
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[[Category: Schiff base]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:08:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:09:35 2008''
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Revision as of 08:08, 3 May 2008

Image:1ufj.gif

Template:STRUCTURE 1ufj

Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin


Overview

Apo-myoglobin (apo-Mb) and apo-A71GMb were successfully reconstituted with FeIII(salophen) (1) (salophen = N,N'-bis(salicylidene)-1,2-phenilenediamine), Fe(III)(3,3'-Me2-salophen) (2), and FeIII(5,5'-t-Bu2-salophen) (3). The crystal structure of 2.apo-A71GMb shows the tight binding of the complex in the Mb cavity, while in wild-type apo-Mb it is highly disordered due to the steric repulsion with Ala71. Furthermore, the structure of 2.apo-A71GMb suggests a possible accommodation of a small substrate in the cavity. In fact, the cyanide association rate constant of 2.apo-A71GMb is 216-fold larger compared to that of 2.apo-Mb. These results provide us principles for the noncovalent fixation of synthetic metal cofactors at the desired positions in protein matrixes.

About this Structure

1UFJ is a Single protein structure of sequence from Physeter catodon. Full crystallographic information is available from OCA.

Reference

Crystal structures of artificial metalloproteins: tight binding of FeIII(Schiff-Base) by mutation of Ala71 to Gly in apo-myoglobin., Ueno T, Ohashi M, Kono M, Kondo K, Suzuki A, Yamane T, Watanabe Y, Inorg Chem. 2004 May 3;43(9):2852-8. PMID:15106972 Page seeded by OCA on Sat May 3 11:08:57 2008

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