4j1a
From Proteopedia
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| - | {{STRUCTURE_4j1a| PDB=4j1a | SCENE= }} | ||
| - | ===X-ray structure of the adduct between hen egg white lysozyme and AziRu (green crystal)=== | ||
| - | {{ABSTRACT_PUBMED_23517183}} | ||
| - | == | + | ==X-ray structure of the adduct between hen egg white lysozyme and AziRu (green crystal)== |
| - | [[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK | + | <StructureSection load='4j1a' size='340' side='right'caption='[[4j1a]], [[Resolution|resolution]] 1.79Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4j1a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J1A FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1a OCA], [https://pdbe.org/4j1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j1a RCSB], [https://www.ebi.ac.uk/pdbsum/4j1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1a ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The binding properties of AziRu, a ruthenium(III) complex with high antiproliferative activity, toward a hen egg white lysozyme have been investigated by X-ray crystallography and Raman microscopy. The data provide clear evidence on the mechanism of AziRu-protein adduct formation and of ligand exchange in the crystal state. | ||
| - | + | Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu.,Vergara A, D'Errico G, Montesarchio D, Mangiapia G, Paduano L, Merlino A Inorg Chem. 2013 Mar 22. PMID:23517183<ref>PMID:23517183</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | <references | + | </div> |
| + | <div class="pdbe-citations 4j1a" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Merlino | + | [[Category: Merlino A]] |
| - | [[Category: Vergara | + | [[Category: Vergara A]] |
| - | + | ||
| - | + | ||
Current revision
X-ray structure of the adduct between hen egg white lysozyme and AziRu (green crystal)
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