3ij4

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{{Seed}}
 
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[[Image:3ij4.jpg|left|200px]]
 
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==Cesium sites in the crystal structure of a functional acid sensing ion channel in the desensitized state==
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The line below this paragraph, containing "STRUCTURE_3ij4", creates the "Structure Box" on the page.
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<StructureSection load='3ij4' size='340' side='right'caption='[[3ij4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ij4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IJ4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene></td></tr>
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{{STRUCTURE_3ij4| PDB=3ij4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ij4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ij4 OCA], [https://pdbe.org/3ij4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ij4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ij4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ij4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ij/3ij4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ij4 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Acid-sensing ion channels are proton-activated, sodium-selective channels composed of three subunits, and are members of the superfamily of epithelial sodium channels, mechanosensitive and FMRF-amide peptide-gated ion channels. These ubiquitous eukaryotic ion channels have essential roles in biological activities as diverse as sodium homeostasis, taste and pain. Despite their crucial roles in biology and their unusual trimeric subunit stoichiometry, there is little knowledge of the structural and chemical principles underlying their ion channel architecture and ion-binding sites. Here we present the structure of a functional acid-sensing ion channel in a desensitized state at 3 A resolution, the location and composition of the approximately 8 A 'thick' desensitization gate, and the trigonal antiprism coordination of caesium ions bound in the extracellular vestibule. Comparison of the acid-sensing ion channel structure with the ATP-gated P2X(4) receptor reveals similarity in pore architecture and aqueous vestibules, suggesting that there are unanticipated yet common structural and mechanistic principles.
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===Cesium sites in the crystal structure of a functional acid sensing ion channel in the desensitized state===
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Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.,Gonzales EB, Kawate T, Gouaux E Nature. 2009 Jul 30;460(7255):599-604. PMID:19641589<ref>PMID:19641589</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ij4" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19641589}}, adds the Publication Abstract to the page
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19641589 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19641589}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3IJ4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IJ4 OCA].
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==Reference==
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<ref group="xtra">PMID:19641589</ref><references group="xtra"/>
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Gonzales, E B.]]
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[[Category: Large Structures]]
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[[Category: Gouaux, E.]]
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[[Category: Gonzales EB]]
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[[Category: Acid-sensing]]
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[[Category: Gouaux E]]
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[[Category: Anomalous]]
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[[Category: Cell membrane]]
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[[Category: Cesium]]
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[[Category: Functional]]
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[[Category: Glycoprotein]]
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[[Category: Ion channel]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Sodium]]
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[[Category: Sodium channel]]
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[[Category: Sodium transport]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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[[Category: Trimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:29:33 2009''
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Current revision

Cesium sites in the crystal structure of a functional acid sensing ion channel in the desensitized state

PDB ID 3ij4

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