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1upl

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[[Image:1upl.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1upl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upl OCA], [http://www.ebi.ac.uk/pdbsum/1upl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1upl RCSB]</span>
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'''CRYSTAL STRUCTURE OF MO25 ALPHA'''
'''CRYSTAL STRUCTURE OF MO25 ALPHA'''
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[[Category: Deak, M.]]
[[Category: Deak, M.]]
[[Category: Milburn, C C.]]
[[Category: Milburn, C C.]]
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[[Category: armadillo]]
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[[Category: Armadillo]]
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[[Category: lkb1]]
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[[Category: Lkb1]]
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[[Category: mo25]]
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[[Category: Mo25]]
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[[Category: strad]]
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[[Category: Strad]]
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Revision as of 08:32, 3 May 2008

Image:1upl.jpg

Template:STRUCTURE 1upl

CRYSTAL STRUCTURE OF MO25 ALPHA


Overview

Mouse protein 25 alpha (MO25 alpha) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25 alpha binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. The MO25 alpha crystal structure reveals a helical repeat fold, distantly related to the Armadillo proteins. A complex with the STRAD alpha peptide reveals a hydrophobic pocket that is involved in a unique and specific interaction with the Trp-Glu-Phe motif, further supported by mutagenesis studies. The data represent a first step toward structural analysis of the LKB1-STRAD-MO25 complex, and suggests that MO25 alpha is a scaffold protein to which other regions of STRAD-LKB1, cellular LKB1 substrates or regulatory components could bind.

About this Structure

1UPL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor., Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM, Nat Struct Mol Biol. 2004 Feb;11(2):193-200. Epub 2004 Jan 18. PMID:14730349 Page seeded by OCA on Sat May 3 11:32:21 2008

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