Carboxypeptidase 3D structures

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(New page: == 3D Structures of Carboxypeptidase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *'''Carboxypeptidase A''' ...)
Current revision (08:16, 6 January 2025) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 6: Line 6:
*'''Carboxypeptidase A'''
*'''Carboxypeptidase A'''
 +
**[[2v77]] – hCPA1 – human<br />
**[[5cpa]], [[1yme]], [[1cps]], [[1ee3]], [[1cpx]], [[1m4l]] – bCPA – bovine<br />
**[[5cpa]], [[1yme]], [[1cps]], [[1ee3]], [[1cpx]], [[1m4l]] – bCPA – bovine<br />
**[[1arl]] – bCPA <br />
**[[1arl]] – bCPA <br />
Line 12: Line 13:
**[[1ka2]], [[1ka4]] - PfCPA Zn-substituted<br />
**[[1ka2]], [[1ka4]] - PfCPA Zn-substituted<br />
**[[5wvu]], [[3hoa]] – CPA – ''Thermus thermophilus''<br />
**[[5wvu]], [[3hoa]] – CPA – ''Thermus thermophilus''<br />
-
**[[2v77]] – hCPA1 – human<br />
 
**[[3dwc]] – CPA – ''Trypanosoma cruzi''<br />
**[[3dwc]] – CPA – ''Trypanosoma cruzi''<br />
**[[3g23]] – CPA – ''Novosphingobium aromaticivorans''<br />
**[[3g23]] – CPA – ''Novosphingobium aromaticivorans''<br />
Line 21: Line 21:
*''CPA complex with small molecules''
*''CPA complex with small molecules''
 +
**[[2pcu]] – hCPA4 + peptide <br />
 +
**[[4uee]], [[6i6z]], [[4uez]] – hCPA1 + peptide inhibitor<br />
 +
**[[5om9]] – hCPA1 + inhibitor<br />
**[[3cpa]] – bCPA + glycyl-tyrosine <br />
**[[3cpa]] – bCPA + glycyl-tyrosine <br />
**[[1f57]] – bCPA + cysteine<br />
**[[1f57]] – bCPA + cysteine<br />
Line 28: Line 31:
**[[3i1u]] – bCPA + thiirane<br />
**[[3i1u]] – bCPA + thiirane<br />
**[[2ctb]], [[2ctc]] – bCPA + phenyl lactate<br />
**[[2ctb]], [[2ctc]] – bCPA + phenyl lactate<br />
-
**[[2pcu]] – hCPA4 + peptide <br />
 
-
**[[4uee]], [[4uef]], [[4uez]] – hCPA1 + peptide inhibitor<br />
 
-
**[[4uf4]], [[5om9]], [[6i6z]] – hCPA1 + inhibitor<br />
 
**[[4oxd]] – SpCP + peptidoglycan<br />
**[[4oxd]] – SpCP + peptidoglycan<br />
*''CPA complex with protein''
*''CPA complex with protein''
-
**[[1zlh]] – bCPA + tick inhibitor<br />
 
-
**[[4cpa]] – bCPA + potato inhibitor<br />
 
-
**[[2abz]] - bCPA + metallo-CP inhibitor<br />
 
**[[3fju]] – hCPA1 + ascaris inhibitor<br />
**[[3fju]] – hCPA1 + ascaris inhibitor<br />
**[[1dtd]] – hCPA2 + metallo-CP inhibitor<br />
**[[1dtd]] – hCPA2 + metallo-CP inhibitor<br />
Line 43: Line 40:
**[[4bd9]] - hCPA4 hydrolase domain + SMCI inhibitor<br />
**[[4bd9]] - hCPA4 hydrolase domain + SMCI inhibitor<br />
**[[4a94]] – hCPA4 + nerita versicolor inhibitor<br />
**[[4a94]] – hCPA4 + nerita versicolor inhibitor<br />
 +
**[[1zlh]] – bCPA + tick inhibitor<br />
 +
**[[4cpa]] – bCPA + potato inhibitor<br />
 +
**[[2abz]] - bCPA + metallo-CP inhibitor<br />
*'''Procarboxypeptidase A'''
*'''Procarboxypeptidase A'''
 +
**[[1aye]] – hPCPA2 <br />
 +
**[[1o6x]] – hPCPA2 activation domain – NMR<BR />
 +
**[[2boa]] – hPCPA4<br />
**[[1fon]] – bPCPA subunit III<br />
**[[1fon]] – bPCPA subunit III<br />
**[[1pyt]] – bPCPA + proproteinase E + chymotrypsinogen C<br />
**[[1pyt]] – bPCPA + proproteinase E + chymotrypsinogen C<br />
**[[1jqg]] – PCPA – Cotton bollworm<br />
**[[1jqg]] – PCPA – Cotton bollworm<br />
-
**[[1aye]] – hPCPA2 <br />
 
-
**[[1o6x]] – hPCPA2 activation domain – NMR<BR />
 
-
**[[2boa]] – hPCPA4<br />
 
*'''Carboxypeptidase B'''
*'''Carboxypeptidase B'''
-
**[[1cpb]], [[3dgv]] – bCPB <br />
 
-
**[[3d4u]], [[3osl]] – bCPB + CP inhibitor<br />
 
-
**[[2c1c]] – CPB – Corn earworm<br />
 
-
**[[3glj]] – pCPB residues 16-416 - pig<br />
 
-
**[[5jc6]] – pCPB catalytic domain residues 111-416 <br />
 
-
**[[3wab]], [[3wc5]], [[3wc6]], [[3wc7]], [[5lyf]], [[5lyi]], [[5lyl]], [[4z65]], [[4uia]], [[2piy]], [[2piz]], [[2pj0]], [[2pj1]], [[2pj2]], [[2pj3]], [[2pj4]], [[2pj5]], [[2pj6]], [[2pj7]], [[2pj8]], [[2pj9]], [[2pja]], [[2pjb]], [[2pjc]], [[5j1q]], [[5zeq]] – pCPB catalytic domain + inhibitor<br />
 
-
**[[5lyd]], [[4uib]] – pCPB catalytic domain (mutant) + inhibitor<br />
 
-
**[[5lrg]], [[5lrj]], [[5lrk]] – pCPB catalytic domain + anabaenopepsin peptide<br />
 
**[[3d66]] – hCPB 2<br />
**[[3d66]] – hCPB 2<br />
**[[3d68]] – hCPB 2 (mutant)<br />
**[[3d68]] – hCPB 2 (mutant)<br />
**[[3lms]] – hCPB 2 + protein inhibitor<br />
**[[3lms]] – hCPB 2 + protein inhibitor<br />
**[[5hvf]], [[5hvg]], [[5hvh]] – hCPB 2 (mutant) + nanobody inhibitor<br />
**[[5hvf]], [[5hvg]], [[5hvh]] – hCPB 2 (mutant) + nanobody inhibitor<br />
 +
**[[7nee]], [[7neu]] – hCPB 2 + inhibitor<br />
**[[4p10]] – hCPB 2 (mutant) + inhibitor<br />
**[[4p10]] – hCPB 2 (mutant) + inhibitor<br />
**[[3d67]] – hCPB 2 + GEMSA<br />
**[[3d67]] – hCPB 2 + GEMSA<br />
**[[1zli]] - hCPB + tick inhibitor<br />
**[[1zli]] - hCPB + tick inhibitor<br />
 +
**[[1cpb]], [[3dgv]] – bCPB <br />
 +
**[[3d4u]], [[3osl]] – bCPB + CP inhibitor<br />
 +
**[[3glj]] – pCPB residues 16-416 - pig<br />
 +
**[[5jc6]] – pCPB catalytic domain residues 111-416 <br />
 +
**[[3wab]], [[3wc5]], [[3wc6]], [[3wc7]], [[5lyf]], [[5lyi]], [[5lyl]], [[4z65]], [[4uia]], [[2piy]], [[2piz]], [[2pj0]], [[2pj1]], [[2pj2]], [[2pj3]], [[2pj4]], [[2pj5]], [[2pj6]], [[2pj7]], [[2pj8]], [[2pj9]], [[2pja]], [[2pjb]], [[2pjc]], [[5j1q]], [[5zeq]] – pCPB catalytic domain + inhibitor<br />
 +
**[[5lyd]], [[4uib]] – pCPB catalytic domain (mutant) + inhibitor<br />
 +
**[[5lrg]], [[5lrj]], [[5lrk]] – pCPB catalytic domain + anabaenopepsin peptide<br />
 +
**[[2c1c]] – CPB – Corn earworm<br />
*'''Procarboxypeptidase B'''
*'''Procarboxypeptidase B'''
 +
**[[1kwm]] - hPCPB<br />
**[[1pba]] – pPCPB activation domain – NMR<BR />
**[[1pba]] – pPCPB activation domain – NMR<BR />
**[[1nsa]] – pPCPB<br />
**[[1nsa]] – pPCPB<br />
**[[1z5r]] - pPCPB catalytic domain<br />
**[[1z5r]] - pPCPB catalytic domain<br />
-
**[[1kwm]] - hPCPB<br />
 
**[[1pca]] – pPCPB + valine<br />
**[[1pca]] – pPCPB + valine<br />
**[[1zg7]], [[1zg8]], [[1zg9]] – pPCPB + inhibitor<br />
**[[1zg7]], [[1zg8]], [[1zg9]] – pPCPB + inhibitor<br />
Line 82: Line 83:
*'''Carboxypeptidase D'''
*'''Carboxypeptidase D'''
 +
**[[5aq0]] – hCPD transthyretin-like domain<br />
**[[1qmu]] – dCPD domain II - duck <br />
**[[1qmu]] – dCPD domain II - duck <br />
**[[1h8l]] - dCPD domain II + GEMSA<br />
**[[1h8l]] - dCPD domain II + GEMSA<br />
**[[3mn8]] – DmCPD + GEMSA – ''Drosophila melanogaster''<br />
**[[3mn8]] – DmCPD + GEMSA – ''Drosophila melanogaster''<br />
-
**[[5aq0]] – hCPD transthyretin-like domain<br />
 
*'''Dipeptidyl carboxypeptidase I'''
*'''Dipeptidyl carboxypeptidase I'''
Line 96: Line 97:
*''Dipeptidyl carboxypeptidase I complexes''
*''Dipeptidyl carboxypeptidase I complexes''
-
**[[2x8z]], [[2x90]], [[2x91]], [[2x92]], [[2x93]], [[2x94]], [[2x95]], [[2x96]], [[2x97]] – DmCPI + anti-hypersensitive drug<br />
 
-
**[[2xhm]] - DmCPI + phosphate derivative<br />
 
**[[2oc2]], [[2xy9]], [[2xyd]] – hCPI + phosphate derivative<br />
**[[2oc2]], [[2xy9]], [[2xyd]] – hCPI + phosphate derivative<br />
**[[3nxq]] - hCPI (mutant) + phosphate derivative<br />
**[[3nxq]] - hCPI (mutant) + phosphate derivative<br />
**[[3bkk]], [[3bkl]], [[3l3n]] – hCPI + inhibitor<br />
**[[3bkk]], [[3bkl]], [[3l3n]] – hCPI + inhibitor<br />
**[[2ydm]], [[3zqz]] – hCPI + captopril derivative<br />
**[[2ydm]], [[3zqz]] – hCPI + captopril derivative<br />
 +
**[[2x8z]], [[2x90]], [[2x91]], [[2x92]], [[2x93]], [[2x94]], [[2x95]], [[2x96]], [[2x97]] – DmCPI + anti-hypersensitive drug<br />
 +
**[[2xhm]] - DmCPI + phosphate derivative<br />
**[[5l44]] – AhCPI + peptide inhibitor <br />
**[[5l44]] – AhCPI + peptide inhibitor <br />
Line 119: Line 120:
**[[5mrv]] – hCPO + metallo-CP inhibitor<br />
**[[5mrv]] – hCPO + metallo-CP inhibitor<br />
 +
 +
*'''Carboxypeptidase S9'''
 +
 +
**[[8wt1]] – CPS9 – ''Geobacillus stearothermophilus''<br />
*'''Carboxypeptidase T'''
*'''Carboxypeptidase T'''
**[[1obr]], [[3qnv]] – TvCPT – ''Thermoaclinomyces vulgaris''<br />
**[[1obr]], [[3qnv]] – TvCPT – ''Thermoaclinomyces vulgaris''<br />
-
**[[3prt]], [[3v38]], [[4ihm]] – TvCPT (mutant)<br />
+
**[[3prt]], [[3v38]], [[4ihm]], [[8qvo]] – TvCPT (mutant)<br />
-
**[[4djl]], [[5myh]], [[6go2]] – TvCPT + sulfamoyl derivative<br />
+
**[[4djl]], [[6sn6]], [[6go2]], [[6t9y]], [[6tnk]] – TvCPT + sulfamoyl derivative<br />
-
**[[4iav]], [[6q4l]], [[6f79]], [[6f75]], [[6f6q]] – TvCPT (mutant) + sulfamoyl derivative<br />
+
**[[4iav]], [[6f79]], [[6f75]], [[6f6q]], [[6z28]] – TvCPT (mutant) + sulfamoyl derivative<br />
**[[4duk]] – TvCPT + benzyl succinic acid<br />
**[[4duk]] – TvCPT + benzyl succinic acid<br />
**[[4f8z]] – TvCPT + leucine derivative<br />
**[[4f8z]] – TvCPT + leucine derivative<br />
Line 131: Line 136:
**[[4gm5]] – TvCPT + arginine derivative<br />
**[[4gm5]] – TvCPT + arginine derivative<br />
**[[3v7z]] – TvCPT + GEMSA<br />
**[[3v7z]] – TvCPT + GEMSA<br />
 +
**[[7q87]] – TvCPT + phenyllactic acid<br />
*'''Carboxypeptidase Y'''
*'''Carboxypeptidase Y'''
Line 160: Line 166:
**[[4rye]] – MtAACP <br />
**[[4rye]] – MtAACP <br />
**[[5fsr]] – EcAACP <br />
**[[5fsr]] – EcAACP <br />
 +
**[[5tr7]] – AACP – ''Vibrio cholerae''<br />
 +
**[[6osu]] – AACP – ''Francisella tularensis''<br />
**[[3pte]], [[1skf]] – StAACP – ''Streptomyces''<br />
**[[3pte]], [[1skf]] – StAACP – ''Streptomyces''<br />
**[[1es2]], [[1es3]], [[1es4]], [[1es5]], [[1esi]], [[1j9m]] – StAACP (mutant) <br />
**[[1es2]], [[1es3]], [[1es4]], [[1es5]], [[1esi]], [[1j9m]] – StAACP (mutant) <br />
 +
**[[1cef]], [[1ceg]], [[1hvb]], [[1pw1]], [[1pw8]], [[1pwc]], [[1pwd]], [[1pwg]] – StAACP + antibiotic<br />
 +
**[[1ikg]], [[1iki]] – StAACP + peptidoglycan fragment<br />
 +
**[[1mpl]] - StAACP + phosphonate inhibitor<br />
 +
**[[1scw]], [[1sde]] - StAACP + cyclic phosphate inhibitor<br />
 +
**[[1yqs]] - StAACP + sultam inhibitor<br />
**[[1lbu]] – SaAACP + Zn – ''Streptomyces albus''<br />
**[[1lbu]] – SaAACP + Zn – ''Streptomyces albus''<br />
**[[6c39]] – AACP + Zn – ''Staphylococcus aureus''<br />
**[[6c39]] – AACP + Zn – ''Staphylococcus aureus''<br />
Line 169: Line 182:
**[[5zhw]] – EfAACP + Zn + Ala-Ala<br />
**[[5zhw]] – EfAACP + Zn + Ala-Ala<br />
**[[2wke]], [[1w8y]], [[2vgj]], [[2vgk]], [[4ben]] - AcAACP + antibiotic<br />
**[[2wke]], [[1w8y]], [[2vgj]], [[2vgk]], [[4ben]] - AcAACP + antibiotic<br />
-
**[[1cef]], [[1ceg]], [[1hvb]], [[1pw1]], [[1pw8]], [[1pwc]], [[1pwd]], **[[1pwg]] – StAACP + antibiotic<br />
 
**[[2xdm]], [[2xk1]], [[2xln]], [[2y4a]], [[2y55]], [[2y59]], [[3zvt]], [[3zvw]], [[4b4x]], [[4b4z]] – AcAACP + boronic acid derivative<br />
**[[2xdm]], [[2xk1]], [[2xln]], [[2y4a]], [[2y55]], [[2y59]], [[3zvt]], [[3zvw]], [[4b4x]], [[4b4z]] – AcAACP + boronic acid derivative<br />
-
**[[1ikg]], [[1iki]] – StAACP + peptidoglycan fragment<br />
 
-
**[[1mpl]] - StAACP + phosphonate inhibitor<br />
 
-
**[[1scw]], [[1sde]] - StAACP + cyclic phosphate inhibitor<br />
 
-
**[[1yqs]] - StAACP + sultam inhibitor<br />
 
**[[3zcz]] – AcAACP + inhibitor<br />
**[[3zcz]] – AcAACP + inhibitor<br />
**[[5j8x]] – EcAACP + inhibitor<br />
**[[5j8x]] – EcAACP + inhibitor<br />
Line 187: Line 195:
**[[1z8l]], [[2oot]] – hECP II<br />
**[[1z8l]], [[2oot]] – hECP II<br />
-
**[[2c6c]], [[2jbj]], [[2jbk]], [[2or4]], [[3d7d]], [[3d7f]], [[3d7g]], [[3d7h]], [[3iww]], [[3sjf]], [[4jyw]], [[4jz0]], [[4lqg]], [[5ely]], [[5d29]], [[4x3r]], [[4w9y]], [[6hkz]], [[6hkj]], [[6h7z]], [[6h7y]], [[6f5l]], [[6ety]] – hECP II + inhibitor<br />
+
**[[2c6c]], [[2jbj]], [[2jbk]], [[2or4]], [[3d7d]], [[3d7f]], [[3d7g]], [[3d7h]], [[3iww]], [[3sjf]], [[4jyw]], [[4jz0]], [[4lqg]], [[5ely]], [[5d29]], [[4x3r]], [[4w9y]], [[6hkz]], [[6hkj]], [[6h7z]], [[6h7y]], [[6f5l]], [[6ety]], [[6rbc]], [[6skh]], [[8bo8]], [[8bol]], [[8bow]] – hECP II + inhibitor<br />
-
**[[6fe5]], [[6ez9]], [[5of0]] - hECP II (mutant) + inhibitor<br />
+
**[[6fe5]], [[6ez9]], [[5of0]], [[6s1x]] - hECP II (mutant) + inhibitor<br />
**[[4p44]], [[4p45]], [[4p4e]], [[4p4d]], [[4p4f]], [[4p4i]], [[4p4j]], [[4p4b]] – hECP II + phosphoramidate inhibitor<br />
**[[4p44]], [[4p45]], [[4p4e]], [[4p4d]], [[4p4f]], [[4p4i]], [[4p4j]], [[4p4b]] – hECP II + phosphoramidate inhibitor<br />
**[[4ngm]], [[4ngn]], [[4ngp]], [[4ngq]], [[4ngr]], [[4ngs]], [[4ngt]], [[4oc0]], [[4oc1]], [[4oc2]], [[4oc3]], [[4oc4]], [[4oc5]], [[4ome]], [[5o5u]], [[5o5t]], [[5o5r]] - hECP II + urea derivative<br />
**[[4ngm]], [[4ngn]], [[4ngp]], [[4ngq]], [[4ngr]], [[4ngs]], [[4ngt]], [[4oc0]], [[4oc1]], [[4oc2]], [[4oc3]], [[4oc4]], [[4oc5]], [[4ome]], [[5o5u]], [[5o5t]], [[5o5r]] - hECP II + urea derivative<br />
Line 199: Line 207:
**[[2c6p]], [[2pvw]] - hECP II + phosphate derivative<br />
**[[2c6p]], [[2pvw]] - hECP II + phosphate derivative<br />
**[[3rbu]] – hECP II + PMPA<br />
**[[3rbu]] – hECP II + PMPA<br />
 +
**[[6rti]] – hECP II + aptamer<br />
**[[3bxm]] – hECP II (mutant) + dipeptide<br />
**[[3bxm]] – hECP II (mutant) + dipeptide<br />
**[[3sje]], [[3sjg]], [[3sjx]] - hECP II (mutant) + inhibitor<br />
**[[3sje]], [[3sjg]], [[3sjx]] - hECP II (mutant) + inhibitor<br />
Line 214: Line 223:
**[[3n2z]] - hPCP
**[[3n2z]] - hPCP
 +
 +
*'''Tubulinyl-Tyr carboxypeptidase'''
 +
 +
**[[6j4u]], [[6j91]], [[6j9h]], [[6k81]], [[6lpg]], [[6ocf]] – hTTCP 1 + vasohibin-binding protein<br />
 +
**[[6j8n]], [[6nvq]] – hTTCP 1 (mutant) + vasohibin-binding protein<br />
 +
**[[6j7b]] – hTTCP 1 + vasohibin-binding protein + tubulinyl-Tyr derivative<br />
 +
**[[6j8f]] – hTTCP 1 + vasohibin-binding protein + tubulin peptide<br />
 +
**[[6j7b]], [[6ocg]] – hTTCP 1 + vasohibin-binding protein + Tyr derivative<br />
 +
**[[6och]] – hTTCP 1 + vasohibin-binding protein + parthenolide<br />
 +
**[[6wsl]] – hTTCP 1 + small vasohibin-binding protein + tubulin alpha-1A chain + tubulin beta-3 chain – Cryo EM<BR />
 +
**[[6j4o]], [[6j4p]], [[6j4q]], [[6j4s]], [[6j4u]], [[6j8n]], [[6j91]], [[6qby]] – hTTCP 2 + vasohibin-binding protein<br />
 +
**[[6j4p]] – hTTCP 2 + small vasohibin-binding protein + Tyr derivative<BR />
 +
**[[6j4v]] – hTTCP 2 + small vasohibin-binding protein + tubulin alpha-1B chain<BR />
 +
**[[6j8o]] – hTTCP 2 + vasohibin-binding protein + peptide<br />
 +
**[[7zcw]] – hTTCP 2 + small vasohibin-binding protein + tubulin alpha-1B chain + tubulin beta-2B chain – Cryo EM<BR />
 +
**[[6jzc]], [[6jze]] – mTTCP 2 + vasohibin-binding protein - mouse<br />
 +
**[[6jzd]] – mTTCP 2 + vasohibin-binding protein + peptide<br />
*'''Angiotensin-converting enzyme-related carboxypeptidase'''
*'''Angiotensin-converting enzyme-related carboxypeptidase'''
Line 226: Line 252:
**[[1lbu]] – SaCP<br />
**[[1lbu]] – SaCP<br />
 +
 +
*'''Muramoyl tetrapeptide carboxypeptidase'''
 +
 +
**[[6uuk]] – CP – Oxalobacter formigenes<br />
*'''Metallo-carboxypeptidase'''
*'''Metallo-carboxypeptidase'''

Current revision

3D Structures of Carboxypeptidase

Updated on 06-January-2025

See Angiotensin-Converting Enzyme

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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