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1uup

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[[Image:1uup.gif|left|200px]]
[[Image:1uup.gif|left|200px]]
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{{Structure
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|PDB= 1uup |SIZE=350|CAPTION= <scene name='initialview01'>1uup</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1uup", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ZN1:Zn+Binding+Site+For+Chain+D'>ZN1</scene>
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1uup| PDB=1uup | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uup OCA], [http://www.ebi.ac.uk/pdbsum/1uup PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uup RCSB]</span>
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'''CRYSTAL STRUCTURE OF A DIMERIC FORM OF STREPTOCOCCAL PYROGENIC EXOTOXIN A (SPEA1).'''
'''CRYSTAL STRUCTURE OF A DIMERIC FORM OF STREPTOCOCCAL PYROGENIC EXOTOXIN A (SPEA1).'''
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[[Category: Collins, C M.]]
[[Category: Collins, C M.]]
[[Category: Gendlina, I.]]
[[Category: Gendlina, I.]]
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[[Category: dimer]]
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[[Category: Dimer]]
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[[Category: exotoxin]]
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[[Category: Exotoxin]]
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[[Category: molecular recognition]]
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[[Category: Molecular recognition]]
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[[Category: superantigen]]
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[[Category: Superantigen]]
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[[Category: toxin]]
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[[Category: Toxin]]
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[[Category: x-ray crystallography]]
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[[Category: X-ray crystallography]]
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[[Category: zinc binding]]
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[[Category: Zinc binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:43:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:15:37 2008''
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Revision as of 08:43, 3 May 2008

Image:1uup.gif

Template:STRUCTURE 1uup

CRYSTAL STRUCTURE OF A DIMERIC FORM OF STREPTOCOCCAL PYROGENIC EXOTOXIN A (SPEA1).


Overview

Streptococcal pyrogenic exotoxin A (SpeA1) is a bacterial superantigen associated with scarlet fever and streptococcal toxic shock syndrome (STSS). SpeA1 is found in both monomeric and dimeric forms, and previous work suggested that the dimer results from an intermolecular disulfide bond between the cysteines at positions 90 of each monomer. Here, we present the crystal structure of the dimeric form of SpeA1. The toxin crystallizes in the orthorhombic space group P212121, with two dimers in the crystallographic asymmetric unit. The final structure has a crystallographic R-factor of 21.52% for 7248 protein atoms, 136 water molecules, and 4 zinc atoms (one zinc atom per molecule). The implications of SpeA1 dimer on MHC class II and T-cell receptor recognition are discussed.

About this Structure

1UUP is a Single protein structure of sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.

Reference

Crystal structure of a dimeric form of streptococcal pyrogenic exotoxin A (SpeA1)., Baker MD, Gendlina I, Collins CM, Acharya KR, Protein Sci. 2004 Sep;13(9):2285-90. Epub 2004 Aug 4. PMID:15295110 Page seeded by OCA on Sat May 3 11:43:03 2008

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