CD44

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<Structure load='2jcq' size='400' frame='true' align='right' caption='Structure of mouse CD44 hyaluronan-binding domain complex with 8-mer HA (PDB entry [[2jcq]])' scene='Insert optional scene name here' />
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<StructureSection load='2jcq' size='350' side='right' scene='' caption='Mouse CD44 hyaluronan-binding domain complex with glucuronic acid, NAG and ethylene glycerol (PDB code [[2jcq]])'>
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'''CD44''' is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.
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== Function ==
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'''CD44''' is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.<ref>PMID:25195884</ref>
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*<scene name='52/523368/Cv/4'>Binding site of CD44 hyaluronan-binding domain</scene> ([[2jcq]]).<ref>PMID:17293874</ref>
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== Relevance ==
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CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases.
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</StructureSection>
==3D structures of CD44==
==3D structures of CD44==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1uuh]], [[4pz4]] – hCD44 hyaluronan-binding domain – human<br />
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[[1uuh]], [[4pz4]] – hCD44 hyaluronan-binding domain 18-171 – human<br />
[[1poz]], [[2i83]] - hCD44 hyaluronan-binding domain – NMR<br />
[[1poz]], [[2i83]] - hCD44 hyaluronan-binding domain – NMR<br />
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[[2jcp]] - mCD44 hyaluronan-binding domain – mouse<br />
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[[4pz3]] - hCD44 hyaluronan-binding domain + tetrapeptide<br /`>
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[[2jcp]] - mCD44 hyaluronan-binding domain 23-172 – mouse<br />
[[2jcq]], [[2jcr]] - mCD44 hyaluronan-binding domain + 8-mer HA<br />
[[2jcq]], [[2jcr]] - mCD44 hyaluronan-binding domain + 8-mer HA<br />
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[[4mrd]], [[4mre]], [[4mrf]], [[4mrg]], [[4mrh]], [[4np2]], [[4np3]] - mCD44 hyaluronan-binding domain + inhibitor<br />
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[[4mrd]], [[4mre]], [[4mrf]], [[4mrg]], [[4mrh]], [[4np2]], , [[4np3]], [[5bzc]], [[5bzk]], [[5sbk]], [[5sbl]], [[5sbm]], [[5sbn]], [[5sbo]], [[5sbp]], [[5sbq]], [[5sbr]], [[5sbs]], [[5sbt]], [[5sbu]], [[5sbv]], [[5sbw]], [[5sbx]], [[5sby]], [[5sbz]], [[5sc0]], [[5sc1]], [[5sc2]], [[5sc3]], [[5sc4]], [[5sc5]], [[5sc6]], [[5sc7]] - mCD44 hyaluronan-binding domain + inhibitor<br />
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[[5bze]], [[5bzf]], [[5bzg]], [[5bzh]], [[5bzi]], [[5bzj]], [[5bzl]], [[5bzm]], [[5bzn]], [[5bzo]], [[5bzp]], [[5bzq]], [[5bzr]], [[5bzs]], [[5bzt]] - mCD44 hyaluronan-binding domain (mutant) + inhibitor<br />
[[4np3]] - mCD44 hyaluronan-binding domain + tetrapeptide<br />
[[4np3]] - mCD44 hyaluronan-binding domain + tetrapeptide<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Mouse CD44 hyaluronan-binding domain complex with glucuronic acid, NAG and ethylene glycerol (PDB code 2jcq)

Drag the structure with the mouse to rotate

3D structures of CD44

Updated on 20-January-2025

1uuh, 4pz4 – hCD44 hyaluronan-binding domain 18-171 – human
1poz, 2i83 - hCD44 hyaluronan-binding domain – NMR
4pz3 - hCD44 hyaluronan-binding domain + tetrapeptide
2jcp - mCD44 hyaluronan-binding domain 23-172 – mouse
2jcq, 2jcr - mCD44 hyaluronan-binding domain + 8-mer HA
4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, , 4np3, 5bzc, 5bzk, 5sbk, 5sbl, 5sbm, 5sbn, 5sbo, 5sbp, 5sbq, 5sbr, 5sbs, 5sbt, 5sbu, 5sbv, 5sbw, 5sbx, 5sby, 5sbz, 5sc0, 5sc1, 5sc2, 5sc3, 5sc4, 5sc5, 5sc6, 5sc7 - mCD44 hyaluronan-binding domain + inhibitor
5bze, 5bzf, 5bzg, 5bzh, 5bzi, 5bzj, 5bzl, 5bzm, 5bzn, 5bzo, 5bzp, 5bzq, 5bzr, 5bzs, 5bzt - mCD44 hyaluronan-binding domain (mutant) + inhibitor
4np3 - mCD44 hyaluronan-binding domain + tetrapeptide

References

  1. ↑ Liu LK, Finzel B. High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction. Acta Crystallogr F Struct Biol Commun. 2014 Sep 1;70(Pt 9):1155-61. doi:, 10.1107/S2053230X14015532. Epub 2014 Aug 29. PMID:25195884 doi:http://dx.doi.org/10.1107/S2053230X14015532
  2. ↑ Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG. Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:17293874 doi:10.1038/nsmb1201

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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