Concanavalin

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[[Image:1nxd.png|left|200px|thumb|Crystal Structure of Concanavalin A, [[1nxd]]]]
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<StructureSection load='1qdc' size='350' side='right' caption='Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry [[1qdc]])' scene='41/415806/Cv/1'>
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{{STRUCTURE_1nxd| PDB=1nxd | SIZE=400| SCENE=Concanavalin_A/Concanavalin_a/1 |right|CAPTION=Concanavalin A complex with glycerol, azide, Mn+2 and Na+ ions, [[1nxd]] }}
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__TOC__
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== Function ==
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'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis''). It binds to certain sugars and to metal. It is used to characterize glycoproteins on cell surfaces.<ref>PMID:9546043</ref>.
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*'''Concanavalin B''' (ConB) is related to chitinase with 40% sequence identity.<ref>PMID:7490746</ref>.
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*'''Concanavalin BR''' (ConBR) is ConA from Brazilian jack bean.
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*'''Concanavalin V''' (ConV) is a D-mannose/D-glucose-binding lectin.
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== Relevance ==
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ConA has therapeutic effect on liver cancer.
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== Structural highlights ==
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ConA is the <scene name='41/415806/Cv/2'>homotetramer</scene> with D2 symmetry. ConA contains a <scene name='41/415806/Cv/7'>metal - Mn+2 and Ca+2 - binding site</scene> as well as a <scene name='41/415806/Cv/8'>sugar binding site</scene>.
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== 3D Structures of Concanavalin ==
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[[Concanavalin 3D structures]]
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</StructureSection>
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== References ==
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<references/>
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'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean ( ''Canavalia ensiformis''). It binds to certain sugars and to metal. It is used to characterize glycoproteins on cell surfaces.
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{{TOC limit|limit=2}}
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== 3D Structures of Concanavalin A ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[2uu8]], [[1nxd]], [[1gkb]], [[3enr]], [[1qny]], [[1vln]], [[1jbc]], [[1cnv]], [[2cna]], [[3cna]], [[3nwk]] – CeConA – ''Canavalia ensiformis''<br />
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[[2yz4]], [[1xqn]], [[1c57]] – CeConA – neutron<br />
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[[2ctv]] – CeConA – Laue<br />
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[[1cn1]], [[1apn]], [[1dq0]], [[1dq2]] – CeConA demetallized<br />
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[[2g4i]], [[2a7a]] – ConA – ''Canavalia virosa''<br />
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[[1wuv]] – CgConA – ''Canavalia gladiata''<br />
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[[3ju9]], [[1azd]] – BrConBR – Brazilian jack-bean<br />
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[[2cwm]] - CmConA – ''Canavalia maritima''
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===Concanavalin binary complex===
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[[1dq1]], [[1dq5]], [[1dq6]], [[1qgl]], [[1nls]], [[1scr]], [[1scs]] – CeConA + ion<br />
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[[1enq]], [[1enr]], [[1ens]], [[1con]], [[1dq4]], [[2enr]], [[1ces]] - CeConA demetallized + ion<br />
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[[3d4k]] – CeConA + sugar analog<br />
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[[1hqw]], [[1jyc]], [[1jyi]], [[1jui]], [[1joj]], [[1jw6]] – CeConA + polypeptide<br />
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[[1jn2]] – CeConA + porphyrin derivative<br />
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[[1cjp]], [[1ona]], [[1gic]], [[1val]], [[1vam]], [[5cna]] – CeConA + pyranoside derivative<br />
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[[1i3h]], [[1qdc]], [[1qdo]], [[1bxh]], [[1tei]], [[1cvn]] – CeConA + glucoside<br />
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[[2p37]], [[2cy6]], [[2cyf]], [[2ow4]], [[2p34]] – CmConA + glucoside <br />
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[[2ef6]], [[2d7f]], [[2ovu]], [[2p2k]] - CgConA + glucoside<br />
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[[3qlq]] - ConA + glucosyl-octasilsesquioxane – ''Canavalia cathartica''<br />
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[[3snm]] - ClConA + indole-acetate – ''Canavalia lineata''<br />
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[[4i30]] – ClConA + adenine<br />
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[[4h55]] - BrConA + glucoside<br />
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[[4dpn]] – ClConA + resveratrol<br />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry 1qdc)

Drag the structure with the mouse to rotate

References

  1. ↑ Loris R, Hamelryck T, Bouckaert J, Wyns L. Legume lectin structure. Biochim Biophys Acta. 1998 Mar 3;1383(1):9-36. PMID:9546043
  2. ↑ Hennig M, Jansonius JN, Terwisscha van Scheltinga AC, Dijkstra BW, Schlesier B. Crystal structure of concanavalin B at 1.65 A resolution. An "inactivated" chitinase from seeds of Canavalia ensiformis. J Mol Biol. 1995 Nov 24;254(2):237-46. PMID:7490746 doi:http://dx.doi.org/10.1006/jmbi.1995.0614

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Michal Harel, Alexander Berchansky, Eran Hodis, Jaime Prilusky

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