Core-binding factor

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Current revision (10:23, 9 February 2025) (edit) (undo)
 
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<StructureSection load='1h9d' size='340' side='right' caption='Human CBFα runt domain (magenta) complex with CBFβ heterodimerization domain (green) and DNA (PDB code [[1h9d]])' scene='70/708082/Cv/1'>
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<StructureSection load='' size='340' side='right' caption='Human CBFα runt domain (magenta) complex with CBFβ heterodimerization domain (green) and DNA (PDB code [[1h9d]])' scene='70/708082/Cv/1'>
== Function ==
== Function ==
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*Core-binding factor β subunit
*Core-binding factor β subunit
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**[[4n9f]] – hCBFb + cullin-5 + elongin-B + virion infectivity factor<br />
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**[[6p59]] – hCBFb + elongin-B + elongin-C + virion infectivity factor<br />
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**[[6nil]] – hCBFb + A3F complex + virion infectivity factor – Cryo EM<br />
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**[[8e40]], [[8h0i]], [[8j62]] – hCBFb + APOBEC + virion infectivity factor + RNA – Cryo EM<br />
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**[[8cx0]], [[8cx1]], [[8cx2]] – hCBFb + elongin-B + elongin-C + APOBEC + virion infectivity factor + RNA – Cryo EM<br />
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**[[8fvi]] – hCBFb + APOBEC + virion infectivity factor + cullin 5 + RNA – Cryo EM<br />
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**[[8fvj]] – hCBFb + elongin-B + elongin-C + virion infectivity factor + cullin 5 – Cryo EM<br />
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**[[8szk]] – hCBFb + elongin-B + elongin-C + virion infectivity factor + cullin 5 + RNA – Cryo EM<br />
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**[[6vg2]], [[6vg8]], [[6vgd]], [[6vge]], [[6vgg]] – hCBFb + Runx2 + FLI1 + DNA<br />
**[[1ilf]] – mCBFb<br />
**[[1ilf]] – mCBFb<br />
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**[[4n9f]] – hCBFb + cullin-5 + transcription elongation factor B + virion infectivity factor<br />
 
*Core-binding factor α+β subunits
*Core-binding factor α+β subunits

Current revision

Human CBFα runt domain (magenta) complex with CBFβ heterodimerization domain (green) and DNA (PDB code 1h9d)

Drag the structure with the mouse to rotate

3D Structures of core-binding factor

Updated on 09-February-2025


References

  1. ↑ Bravo J, Li Z, Speck NA, Warren AJ. The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp. Nat Struct Biol. 2001 Apr;8(4):371-8. PMID:11276260 doi:http://dx.doi.org/10.1038/86264

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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