1v1j

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[[Image:1v1j.gif|left|200px]]
[[Image:1v1j.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1v1j |SIZE=350|CAPTION= <scene name='initialview01'>1v1j</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1v1j", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=DHQ:Trs+Binding+Site+For+Chain+K'>DHQ</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FA3:2-ANHYDRO-3-FLUORO-QUINIC+ACID'>FA3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1v1j| PDB=1v1j | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1j OCA], [http://www.ebi.ac.uk/pdbsum/1v1j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v1j RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO'''
'''CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO'''
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[[Category: Lapthorn, A J.]]
[[Category: Lapthorn, A J.]]
[[Category: Roszak, A W.]]
[[Category: Roszak, A W.]]
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[[Category: aromatic amino acid biosynthesis]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: dehydroquinase]]
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[[Category: Dehydroquinase]]
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[[Category: dhq]]
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[[Category: Dhq]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: shikimate]]
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[[Category: Shikimate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:58:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:18:16 2008''
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Revision as of 08:58, 3 May 2008

Image:1v1j.gif

Template:STRUCTURE 1v1j

CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO


Overview

The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases has been prepared from naturally occurring (-)-quinic acid over seven steps and has been shown to be the most potent inhibitor reported to date of the type II enzyme from Mycobacterium tuberculosis.

About this Structure

1V1J is a Single protein structure of sequence from Streptomyces coelicolor. Full crystallographic information is available from OCA.

Reference

(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases., Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2004 Jun 7;2(11):1592-6. Epub 2004 May 6. PMID:15162210 Page seeded by OCA on Sat May 3 11:58:15 2008

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