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Cyclin 3D structures
From Proteopedia
(Difference between revisions)
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *CYCA | ||
| - | **[[7b5l]] – hCYCA + CDK2 + NEDD8 + cullin-1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 + UBE2L3 + Ub + ARIH1 – human - Cryo EM<br /> | ||
*CYCA2 | *CYCA2 | ||
| - | **[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor <br /> | + | **[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor - human<br /> |
**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]], [[7b7s]], [[7mkx]], [[7qhl]] - hCYCA2 +CDK2 T160P+inhibitor<br /> | **[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]], [[7b7s]], [[7mkx]], [[7qhl]] - hCYCA2 +CDK2 T160P+inhibitor<br /> | ||
| + | **[[8bzo]] - hCYCA2 +CDK2 T160P+ p27 – Cryo EM | ||
**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br /> | **[[1fin]], [[5if1]] - hCYCA2 +CDK2<br /> | ||
**[[1vyw]] - hCYCA2 C-terminal 175-432 + hCDK2<br /> | **[[1vyw]] - hCYCA2 C-terminal 175-432 + hCDK2<br /> | ||
| + | **[[7luo]] - hCYCA2 + SKP2 N-terminal | ||
**[[1jst]], [[3tnw]], [[6sg4]] - hCYCA2 +CDK2 T160P<br /> | **[[1jst]], [[3tnw]], [[6sg4]] - hCYCA2 +CDK2 T160P<br /> | ||
**[[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]] - hCYCA2 +CDK2 T160P+peptide<br /> | **[[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]] - hCYCA2 +CDK2 T160P+peptide<br /> | ||
| - | **[[4bck]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfn]], [[4cfw]], [[6gva]], [[6guf]], [[6gue]], [[6guc]], [[6gub]] - hCYCA2 +CDK2 T160P + inhibitor<br /> | + | **[[4bck]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfn]], [[4cfw]], [[6gva]], [[6guf]], [[6gue]], [[6guc]], [[6gub]], [[8b54]] - hCYCA2 +CDK2 T160P + inhibitor<br /> |
**[[6ath]] - hCYCA2 +CDK2 T160P + cyclin-dependent kinase inhibitor<br /> | **[[6ath]] - hCYCA2 +CDK2 T160P + cyclin-dependent kinase inhibitor<br /> | ||
**[[4fx3]] - hCYCA2 +CDK2 + inhibitor<br /> | **[[4fx3]] - hCYCA2 +CDK2 + inhibitor<br /> | ||
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**[[1jsu]] - hCYCA2 +CDK2 (mutant)+P27<br /> | **[[1jsu]] - hCYCA2 +CDK2 (mutant)+P27<br /> | ||
**[[6q6g]], [[6q6h]] – hCYCA2 in APC/C-CDC20-CDK2-CKS2 complex – Cryo EM<br /> | **[[6q6g]], [[6q6h]] – hCYCA2 in APC/C-CDC20-CDK2-CKS2 complex – Cryo EM<br /> | ||
| + | **[[8bya]] – hCYCA2 + CDK2 + SKP1 + SKP2 + CKS1 + p27 - Cryo EM<br /> | ||
| + | **[[7b5l]] – hCYCA2 + CDK2 + NEDD8 + cullin-1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 + UBE2L3 + Ub + ARIH1 - Cryo EM<br /> | ||
| + | **[[8roz]] – bCYCA2 + CDK2 + CDC25a – bovine - Cryo EM<br /> | ||
**[[3qhr]], [[3khw]] - CYCA2 + P33 protein kinase + CDK2 peptide – mouse | **[[3qhr]], [[3khw]] - CYCA2 + P33 protein kinase + CDK2 peptide – mouse | ||
*CYCA3 | *CYCA3 | ||
| - | **[[1vin]] – CYCA3 - bovine<br /> | ||
**[[1e9h]] – hCYCA3 +CDK2 T160P+inhibitor<br /> | **[[1e9h]] – hCYCA3 +CDK2 T160P+inhibitor<br /> | ||
**[[7sj3]] - hCYCA3 +CDK4 T160P + drug<br /> | **[[7sj3]] - hCYCA3 +CDK4 T160P + drug<br /> | ||
| + | **[[1vin]] – bCYCA3 <br /> | ||
*CYCB1 or G2/mitotic-specific CYCB1 | *CYCB1 or G2/mitotic-specific CYCB1 | ||
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**[[5lqf]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2 + inhibitor<br /> | **[[5lqf]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2 + inhibitor<br /> | ||
**[[7nj0]] – hCYCB1 + hCDK1 + CDK regulatory subunit 1 + separin – Cryo EM<br /> | **[[7nj0]] – hCYCB1 + hCDK1 + CDK regulatory subunit 1 + separin – Cryo EM<br /> | ||
| + | **[[8tar]], [[8tau]] – hCYCB1 in cyclosome complex – Cryo EM<br /> | ||
| + | **[[9fh9]] – hCYCB1 in nucleosome complex – Cryo EM<br /> | ||
*CYCC | *CYCC | ||
**[[3rgf]], [[4g6l]] – hCYCC + CDK8<br /> | **[[3rgf]], [[4g6l]] – hCYCC + CDK8<br /> | ||
| - | **[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]] – hCYCC + CDK8 + inhibitor<br /> | + | **[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]], [[9h8c]], [[9h8s]] – hCYCC + CDK8 + inhibitor<br /> |
**[[6tpa]] – hCYCC + CDK8 + drug<br /> | **[[6tpa]] – hCYCC + CDK8 + drug<br /> | ||
| + | **[[8tq2]], [[8tqc]] – hCYCC + CDK8 + mediator of RNA polymerase transcription subunit 12,13 – Cryo EM<br /> | ||
| + | **[[8tqw]] – hCYCC + CDK8 + mediator of RNA polymerase transcription complex– Cryo EM<br /> | ||
| + | |||
| + | *CYCCCL1 | ||
| + | |||
**[[7kue]] – hCYCCCL1 + TFB3 + Kin28 + ADP – Cryo EM<br /> | **[[7kue]] – hCYCCCL1 + TFB3 + Kin28 + ADP – Cryo EM<br /> | ||
| + | **[[6xi8]] – yCYCCCL1 + TFB3 + Kin28 + ADP – Cryo EM<br /> | ||
*CYCD | *CYCD | ||
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**[[3g33]] – hCYCD3 + CDK4 | **[[3g33]] – hCYCD3 + CDK4 | ||
| - | * | + | *CYCE1 |
**[[1w98]] – hCYCE1 + CDK2 T160P<br /> | **[[1w98]] – hCYCE1 + CDK2 T160P<br /> | ||
**[[7kjs]] – hCYCE1 + CDK2 <br /> | **[[7kjs]] – hCYCE1 + CDK2 <br /> | ||
**[[5l2w]] – hCYCE1 + CDK2 + drug<br /> | **[[5l2w]] – hCYCE1 + CDK2 + drug<br /> | ||
| + | **[[8h6p]], [[8h6t]], [[8vq3]], [[8vq4]] – hCYCE1 + CDK2 + inhibitor<br /> | ||
| + | **[[7xqk]] – hCYCE1 + CDK3 <br /> | ||
| + | **[[8h4r]] – hCYCE1 + CDK3 + drug<br /> | ||
| + | |||
| + | *CYCF | ||
| + | |||
| + | **[[9cb3]] – hCYCF + SKP1 + E2F1 peptide – Cryo EM<br /> | ||
*CYCH | *CYCH | ||
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**[[1kxu]], [[1jkw]] – hCYCH<br /> | **[[1kxu]], [[1jkw]] – hCYCH<br /> | ||
**[[6o9l]] – hCYCH in transcription preinitiation complex – Cryo EM<br /> | **[[6o9l]] – hCYCH in transcription preinitiation complex – Cryo EM<br /> | ||
| - | **[[6xbz]] – hCYCH + CDK7 + MAT1 – Cryo EM<br /> | + | **[[8pyr]] – hCYCH + CDK7 + MAT1 <br /> |
| - | **[[6xd3]], [[7b5o]], [[7b5q]] – hCYCH + CDK7 + MAT1 + inhibitor – Cryo EM<br /> | + | **[[6xbz]], [[8orm]], [[8p6w]], [[8p6x]], [[8p73]], [[8p75]], [[8p79]] – hCYCH + CDK7 + MAT1 – Cryo EM<br /> |
| + | **[[6xd3]], [[7b5o]], [[7b5q]], [[8p6v]], [[8p6z]], [[8p70]], [[8p71]], [[8p72]], [[8p74]], [[8p76]], [[8p77]], [[8plz]], [[8s0t]] – hCYCH + CDK7 + MAT1 + inhibitor – Cryo EM<br /> | ||
| + | **[[8p78]] – hCYCH + CDK7 + MAT1 + drug – Cryo EM<br /> | ||
| + | **[[8p6y]] – hCYCH + CDK7 + MAT1 + ATPgS – Cryo EM<br /> | ||
| + | **[[7nvr]] – hCYCH + hCDK7 in DNA polymerase complex – Cryo EM<br /> | ||
*CYCK | *CYCK | ||
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**[[7nxj]] - hCYCK + CDK13 T160P + inhibitor<br /> | **[[7nxj]] - hCYCK + CDK13 T160P + inhibitor<br /> | ||
**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]], [[7nxj]], [[7nxk]] - hCYCK +CDK12 T160P + inhibitor<br /> | **[[4un0]], [[5acb]], [[6b3e]], [[6ckx]], [[7nxj]], [[7nxk]] - hCYCK +CDK12 T160P + inhibitor<br /> | ||
| - | **[[6td3]] - hCYCK +CDK12 T160P+ DDB1<br /> | + | **[[6td3]], [[8bu1]], [[8bu2]], [[8bu3]], [[8bu4]], [[8bu5]], [[8bu6]], [[8bu7]], [[8bu9]], [[[8bua]], [[8bub]], [[8buc]], [[8bud]], [[8bue]], [[8buf]], [[8bug]], [[8buh]], [[8bui]], [[8buj]], [[8buk]], [[8bul]], [[8bum]], [[8bun]], [[8buo]], [[8bup]], [[8buq]], [[8bur]], [[8bus]], [[8but]], [[9fmr]] - hCYCK +CDK12 T160P+ DDB1 + inhibitor<br /> |
*CYCT | *CYCT | ||
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**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br /> | **[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br /> | ||
**[[3blr]] - hCYCT1 +CDK9+inhibitor<br /> | **[[3blr]] - hCYCT1 +CDK9+inhibitor<br /> | ||
| - | **[[6gzh]], [[6z45]], [[7nwk]] - hCYCT1 TPO160 +CDK9+inhibitor<br /> | + | **[[6gzh]], [[6z45]], [[7nwk]], [[8i0l]] - hCYCT1 TPO160 +CDK9+inhibitor<br /> |
| - | **[[3my1]], [[4ec8]], [[4ec9]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor<br /> | + | **[[3my1]], [[4ec8]], [[4ec9]], [[6w9e]], [[8k5r]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor<br /> |
| - | **[[3mi9]], [[3mia]] - hCYCT1 +CDK9+protein TAT<br /> | + | **[[3mi9]], [[3mia]] - hCYCT1 +CDK9+ protein TAT<br /> |
| - | **[[2w2h]] - CYCT1 +protein TAT + RNA – horse<br /> | + | **[[2w2h]] - CYCT1 + protein TAT + RNA – horse<br /> |
**[[2ivx]] – hCYCT2 (mutant) | **[[2ivx]] – hCYCT2 (mutant) | ||
Current revision
3D Structures of Cyclin
Updated on 17-February-2025
