1v3q

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[[Image:1v3q.gif|left|200px]]
[[Image:1v3q.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1v3q |SIZE=350|CAPTION= <scene name='initialview01'>1v3q</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1v3q", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2DI:9-[(2R,5R)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE'>2DI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1v3q| PDB=1v3q | SCENE= }}
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|RELATEDENTRY=[[1rct|1RCT]], [[1v41|1V41]], [[1v45|1V45]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v3q OCA], [http://www.ebi.ac.uk/pdbsum/1v3q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v3q RCSB]</span>
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}}
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'''Structure of human PNP complexed with DDI'''
'''Structure of human PNP complexed with DDI'''
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[[Category: Santos, D S.]]
[[Category: Santos, D S.]]
[[Category: Silva, R G.]]
[[Category: Silva, R G.]]
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[[Category: crystallography]]
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[[Category: Crystallography]]
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[[Category: ddi]]
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[[Category: Ddi]]
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[[Category: drug design]]
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[[Category: Drug design]]
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[[Category: purine nucleoside phosphorylase]]
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[[Category: Purine nucleoside phosphorylase]]
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[[Category: synchrotorn]]
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[[Category: Synchrotorn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:02:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:19:06 2008''
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Revision as of 09:02, 3 May 2008

Image:1v3q.gif

Template:STRUCTURE 1v3q

Structure of human PNP complexed with DDI


Overview

Human purine nucleoside phosphorylase (PNP) is a ubiquitous enzyme which plays a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effect on B-cell function. PNP is highly specific for 6-oxopurine nucleosides and exhibits negligible activity for 6-aminopurine nucleosides. The catalytic efficiency for inosine is 350,000-fold greater than for adenosine. Adenine nucleosides and nucleotides are deaminated by adenosine deaminase and AMP deaminase to their corresponding inosine derivatives which, in turn, may be further degraded. Here we report the crystal structures of human PNP in complex with inosine and 2('),3(')-dideoxyinosine, refined to 2.8A resolution using synchrotron radiation. The present structures provide explanation for ligand binding, refine the purine-binding site, and can be used for future inhibitor design.

About this Structure

1V3Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of human purine nucleoside phosphorylase complexed with inosine and ddI., Canduri F, dos Santos DM, Silva RG, Mendes MA, Basso LA, Palma MS, de Azevedo WF, Santos DS, Biochem Biophys Res Commun. 2004 Jan 23;313(4):907-14. PMID:14706628 Page seeded by OCA on Sat May 3 12:02:19 2008

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