1v4t

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[[Image:1v4t.gif|left|200px]]
[[Image:1v4t.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1v4t |SIZE=350|CAPTION= <scene name='initialview01'>1v4t</scene>, resolution 3.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1v4t", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1v4t| PDB=1v4t | SCENE= }}
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|RELATEDENTRY=[[1v4t|1V4T]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4t OCA], [http://www.ebi.ac.uk/pdbsum/1v4t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v4t RCSB]</span>
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}}
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'''Crystal structure of human glucokinase'''
'''Crystal structure of human glucokinase'''
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[[Category: Nagata, Y.]]
[[Category: Nagata, Y.]]
[[Category: Nishimura, T.]]
[[Category: Nishimura, T.]]
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[[Category: allosteric enzyme]]
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[[Category: Allosteric enzyme]]
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[[Category: diabetes]]
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[[Category: Diabetes]]
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[[Category: hexokinase iv]]
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[[Category: Hexokinase iv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:04:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:19:27 2008''
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Revision as of 09:04, 3 May 2008

Image:1v4t.gif

Template:STRUCTURE 1v4t

Crystal structure of human glucokinase


Overview

Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. The molecular basis for these two properties is not well understood. Herein we report the crystal structures of glucokinase in its active and inactive forms, which demonstrate that global conformational change, including domain reorganization, is induced by glucose binding. This suggests that the positive cooperativity of monomeric glucokinase obeys the "mnemonical mechanism" rather than the well-known concerted model. These structures also revealed an allosteric site through which small molecules may modulate the kinetic properties of the enzyme. This finding provided the mechanistic basis for activation of glucokinase as a potential therapeutic approach for treating type 2 diabetes mellitus.

About this Structure

1V4T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase., Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y, Structure. 2004 Mar;12(3):429-38. PMID:15016359 Page seeded by OCA on Sat May 3 12:04:36 2008

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