1v7x

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[[Image:1v7x.jpg|left|200px]]
[[Image:1v7x.jpg|left|200px]]
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{{Structure
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|PDB= 1v7x |SIZE=350|CAPTION= <scene name='initialview01'>1v7x</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1v7x", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|GENE= chbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=671 Vibrio proteolyticus])
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{{STRUCTURE_1v7x| PDB=1v7x | SCENE= }}
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|RELATEDENTRY=[[1v7v|1V7V]], [[1v7w|1V7W]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v7x OCA], [http://www.ebi.ac.uk/pdbsum/1v7x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v7x RCSB]</span>
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'''Crystal structure of Vibrio proteolyticus chitobiose phosphorylase in complex with GlcNAc and sulfate'''
'''Crystal structure of Vibrio proteolyticus chitobiose phosphorylase in complex with GlcNAc and sulfate'''
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[[Category: Shoun, H.]]
[[Category: Shoun, H.]]
[[Category: Wakagi, T.]]
[[Category: Wakagi, T.]]
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[[Category: (alpha/alpha)6 barrel]]
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[[Category: Beta-sandwich]]
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[[Category: beta-sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:11:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:20:42 2008''
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Revision as of 09:11, 3 May 2008

Image:1v7x.jpg

Template:STRUCTURE 1v7x

Crystal structure of Vibrio proteolyticus chitobiose phosphorylase in complex with GlcNAc and sulfate


Overview

Vibrio proteolyticus chitobiose phosphorylase (ChBP) belongs to glycosyl transferase family 36 (GT-36), and catalyzes the reversible phosphorolysis of chitobiose into alpha-GlcNAc-1-phosphate and GlcNAc with inversion of the anomeric configuration. As the first known structures of a GT-36 enzyme, we determined the crystal structure of ChBP in a ternary complex with GlcNAc and SO(4). It is also the first structures of an inverting phosphorolytic enzyme in a complex with a sugar and a sulfate ion, and reveals a pseudo-ternary complex structure of enzyme-sugar-phosphate. ChBP comprises a beta sandwich domain and an (alpha/alpha)(6) barrel domain, constituting a distinctive structure among GT families. Instead, it shows significant structural similarity with glycoside hydrolase (GH) enzymes, glucoamylases (GH-15), and maltose phosphorylase (GH-65) in clan GH-L. The structural similarity reported here, together with distant sequence similarities between ChBP and GHs, led to the reclassification of family GT-36 into a novel GH family, namely GH-94.

About this Structure

1V7X is a Single protein structure of sequence from Vibrio proteolyticus. Full crystallographic information is available from OCA.

Reference

Chitobiose phosphorylase from Vibrio proteolyticus, a member of glycosyl transferase family 36, has a clan GH-L-like (alpha/alpha)(6) barrel fold., Hidaka M, Honda Y, Kitaoka M, Nirasawa S, Hayashi K, Wakagi T, Shoun H, Fushinobu S, Structure. 2004 Jun;12(6):937-47. PMID:15274915 Page seeded by OCA on Sat May 3 12:11:38 2008

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