1v9u
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1v9u.gif|left|200px]] | [[Image:1v9u.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1v9u", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | | | + | {{STRUCTURE_1v9u| PDB=1v9u | SCENE= }} |
| - | | | + | |
| - | + | ||
| - | }} | + | |
'''Human Rhinovirus 2 bound to a fragment of its cellular receptor protein''' | '''Human Rhinovirus 2 bound to a fragment of its cellular receptor protein''' | ||
| Line 31: | Line 28: | ||
[[Category: Reithmayer, M.]] | [[Category: Reithmayer, M.]] | ||
[[Category: Verdaguer, N.]] | [[Category: Verdaguer, N.]] | ||
| - | [[Category: | + | [[Category: Human rhinovirus]] |
| - | [[Category: | + | [[Category: Icosahedral virus]] |
| - | [[Category: | + | [[Category: Virus-protein complex]] |
| - | [[Category: | + | [[Category: Vldl-receptor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:16:40 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:16, 3 May 2008
Human Rhinovirus 2 bound to a fragment of its cellular receptor protein
Overview
Although many viral receptors have been identified, the ways in which they interact with their cognate viruses are not understood at the molecular level. We have determined the X-ray structure of a complex between calcium-containing modules of the very low-density lipoprotein receptor and the minor group human rhinovirus HRV2. The receptor binds close to the icosahedral five-fold vertex, with only one module per virus protomer. The binding face of this module is defined by acidic calcium-chelating residues and, in particular, by an exposed tryptophan that is highly conserved. The attachment site on the virus involves only residues from VP1, particularly a lysine strictly conserved in all minor group HRVs. The disposition of the attached ligand-binding repeats around the five-fold axis, together with the proximity of the N- and C-terminal ends of adjacent modules, suggests that more than one repeat in a single receptor molecule might attach simultaneously.
About this Structure
1V9U is a Protein complex structure of sequences from Homo sapiens and Human rhinovirus 2. Full crystallographic information is available from OCA.
Reference
X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein., Verdaguer N, Fita I, Reithmayer M, Moser R, Blaas D, Nat Struct Mol Biol. 2004 May;11(5):429-34. Epub 2004 Apr 4. PMID:15064754 Page seeded by OCA on Sat May 3 12:16:40 2008
