1va4

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[[Image:1va4.gif|left|200px]]
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{{Structure
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|PDB= 1va4 |SIZE=350|CAPTION= <scene name='initialview01'>1va4</scene>, resolution 1.804&Aring;
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The line below this paragraph, containing "STRUCTURE_1va4", creates the "Structure Box" on the page.
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|SITE=
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Arylesterase Arylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.2 3.1.1.2] </span>
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{{STRUCTURE_1va4| PDB=1va4 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1va4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1va4 OCA], [http://www.ebi.ac.uk/pdbsum/1va4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1va4 RCSB]</span>
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'''Pseudomonas fluorescens aryl esterase'''
'''Pseudomonas fluorescens aryl esterase'''
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[[Category: Schrag, J D.]]
[[Category: Schrag, J D.]]
[[Category: Tocilj, A.]]
[[Category: Tocilj, A.]]
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[[Category: alpha/beta hydrolase]]
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[[Category: Alpha/beta hydrolase]]
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[[Category: esterase]]
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[[Category: Esterase]]
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[[Category: non-cofactor dependent haloperoxidase]]
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[[Category: Non-cofactor dependent haloperoxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:17:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:21:35 2008''
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Revision as of 09:17, 3 May 2008

Image:1va4.gif

Template:STRUCTURE 1va4

Pseudomonas fluorescens aryl esterase


Overview

The structure of PFE, an aryl esterase from Pseudomonas fluorescens, has been solved to a resolution of 1.8 A by X-ray diffraction and shows a characteristic alpha/beta-hydrolase fold. In addition to catalyzing the hydrolysis of esters in vitro, PFE also shows low bromoperoxidase activity. PFE shows highest structural similarity, including the active-site environment, to a family of non-heme bacterial haloperoxidases, with an r.m.s. deviation in 271 C(alpha) atoms between PFE and its five closest structural neighbors averaging 0.8 A. PFE has far less similarity (r.m.s. deviation in 218 C(alpha) atoms of 5.0 A) to P. fluorescens carboxyl esterase. PFE favors activated esters with small acyl groups, such as phenyl acetate. The X-ray structure of PFE reveals a significantly occluded active site. In addition, several residues, including Trp28 and Met95, limit the size of the acyl-binding pocket, explaining its preference for small acyl groups.

About this Structure

1VA4 is a Single protein structure of sequence from Pseudomonas fluorescens. Full crystallographic information is available from OCA.

Reference

Structure of an aryl esterase from Pseudomonas fluorescens., Cheeseman JD, Tocilj A, Park S, Schrag JD, Kazlauskas RJ, Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1237-43. Epub 2004, Jun 22. PMID:15213385 Page seeded by OCA on Sat May 3 12:17:21 2008

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