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4mn3
From Proteopedia
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==Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7)== | ==Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7)== | ||
| - | <StructureSection load='4mn3' size='340' side='right' caption='[[4mn3]], [[Resolution|resolution]] 1.54Å' scene=''> | + | <StructureSection load='4mn3' size='340' side='right'caption='[[4mn3]], [[Resolution|resolution]] 1.54Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4mn3]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4mn3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MN3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.542Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn3 OCA], [https://pdbe.org/4mn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mn3 RCSB], [https://www.ebi.ac.uk/pdbsum/4mn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mn3 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CBX7_HUMAN CBX7_HUMAN] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:19636380</ref> <ref>PMID:21060834</ref> <ref>PMID:21282530</ref> <ref>PMID:21047797</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4mn3" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Boulanger | + | [[Category: Large Structures]] |
| - | [[Category: Chakravarthi | + | [[Category: Synthetic construct]] |
| - | [[Category: Daze | + | [[Category: Boulanger MJ]] |
| - | [[Category: Dev | + | [[Category: Chakravarthi S]] |
| - | [[Category: Douglas | + | [[Category: Daze K]] |
| - | [[Category: Heller | + | [[Category: Dev A]] |
| - | [[Category: Hof | + | [[Category: Douglas S]] |
| - | [[Category: Peng | + | [[Category: Heller M]] |
| - | [[Category: Quon | + | [[Category: Hof F]] |
| - | [[Category: Wulff | + | [[Category: Peng F]] |
| - | + | [[Category: Quon T]] | |
| - | + | [[Category: Wulff J]] | |
Current revision
Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7)
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Categories: Homo sapiens | Large Structures | Synthetic construct | Boulanger MJ | Chakravarthi S | Daze K | Dev A | Douglas S | Heller M | Hof F | Peng F | Quon T | Wulff J
