1vex
From Proteopedia
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[[Image:1vex.gif|left|200px]] | [[Image:1vex.gif|left|200px]] | ||
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'''F-spondin TSR domain 4''' | '''F-spondin TSR domain 4''' | ||
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[[Category: Permi, P.]] | [[Category: Permi, P.]] | ||
[[Category: Tossavainen, H.]] | [[Category: Tossavainen, H.]] | ||
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Revision as of 09:27, 3 May 2008
F-spondin TSR domain 4
Overview
F-spondin is a protein mainly associated with neuronal development. It attaches to the extracellular matrix and acts in the axon guidance of the developing nervous system. F-spondin consists of eight domains, six of which are TSR domains. The TSR domain family binds a wide range of targets. Here we present the NMR solution structures of TSR1 and TSR4. TSR domains have an unusual fold that is characterized by a long, nonglobular shape, consisting of two beta-strands and one irregular extended strand. Three disulfide bridges and stack of alternating tryptophan and arginine side-chains stabilize the structure. TSR1 and TSR4 structures are similar to each other and to the previously determined TSR domain X-ray structures from another protein, TSP, although TSR4 exhibits a mobile loop not seen in other structures.
About this Structure
1VEX is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structures of the first and fourth TSR domains of F-spondin., Paakkonen K, Tossavainen H, Permi P, Rakkolainen H, Rauvala H, Raulo E, Kilpelainen I, Guntert P, Proteins. 2006 Aug 15;64(3):665-72. PMID:16736493 Page seeded by OCA on Sat May 3 12:27:44 2008
