Lactoperoxidase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
| - | The <scene name='48/487283/Cv/ | + | The <scene name='48/487283/Cv/6'>peroxidation of thiocyanate catalyzed by LPO occurs at the heme cavity site</scene><ref>PMID:19339248</ref>. Water molecules shown as red spheres. <scene name='48/487283/Cv/7'>Whole active site</scene>. |
</StructureSection> | </StructureSection> | ||
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**[[2pt3]] - bPLO + phosphate - bovine<br /> | **[[2pt3]] - bPLO + phosphate - bovine<br /> | ||
**[[2nqx]], [[5b72]] – bPLO + I<br /> | **[[2nqx]], [[5b72]] – bPLO + I<br /> | ||
| + | **[[7dlq]] – bPLO + H2O2<br /> | ||
**[[2r5l]] – gLPO + I – goat<br /> | **[[2r5l]] – gLPO + I – goat<br /> | ||
**[[3nak]] – gLPO + formate<br /> | **[[3nak]] – gLPO + formate<br /> | ||
| - | **[[ | + | **[[6ky7]], [[7c73]], [[7c74]], [[7c75]], [[7d52]], [[7dao]], [[7de5]], [[7dmr]] – yPLO + Ca - yak<br /> |
| + | **[[7c74]] - yLPO + Cl <br /> | ||
| + | **[[6l32]], [[6l42]], [[7d52]], [[6l5g]], [[7c75]] - yLPO + Zn <br /> | ||
| + | **[[6lqw]], [[7y3u]] – yPLO + H2O2<br /> | ||
| + | **[[7c73]] – yPLO + phosphoserine<br /> | ||
*Lactoperoxidase ternary complex | *Lactoperoxidase ternary complex | ||
| - | **[[2ips]], [[3eri]], [[3gc1]] – bLPO + SCN + I<br /> | + | **[[2ips]], [[3eri]], [[3gc1]], [[6a4y]], [[9m0i]], [[6m7e]], [[7dn7]] – bLPO + SCN + I<br /> |
**[[2qrb]] – bLPO + SCN + Cl<br /> | **[[2qrb]] – bLPO + SCN + Cl<br /> | ||
**[[3bxi]] – bLPO + SCN + nitrate<br /> | **[[3bxi]] – bLPO + SCN + nitrate<br /> | ||
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**[[2pum]] – bPLO + catechol + I<br /> | **[[2pum]] – bPLO + catechol + I<br /> | ||
**[[3krq]] – bLPO + amino-triazole + I<br /> | **[[3krq]] – bLPO + amino-triazole + I<br /> | ||
| + | **[[6kmk]] – bPLO + H2O2 + phosphoserine<br /> | ||
| + | **[[7dlq]], [[7dn6]] – bPLO + H2O2 + I<br /> | ||
**[[2z5z]] – wbPLO + F + I – water buffalo<br /> | **[[2z5z]] – wbPLO + F + I – water buffalo<br /> | ||
**[[2o86]] – wbPLO + nitrate + I<br /> | **[[2o86]] – wbPLO + nitrate + I<br /> | ||
**[[3erh]] - wbLPO + SCN + I<br /> | **[[3erh]] - wbLPO + SCN + I<br /> | ||
| + | **[[7de5]] - yLPO + SCN + I<br /> | ||
**[[2ojv]] – gPLO + CN + I<br /> | **[[2ojv]] – gPLO + CN + I<br /> | ||
**[[3n8f]] - gLPO + SCN + nitrate<br /> | **[[3n8f]] - gLPO + SCN + nitrate<br /> | ||
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**[[3niu]] – gLPO + diethylene glycol + phosphate<br /> | **[[3niu]] – gLPO + diethylene glycol + phosphate<br /> | ||
**[[3rke]] - gPLO + inhibitor + I<br /> | **[[3rke]] - gPLO + inhibitor + I<br /> | ||
| - | **[[2ikc]] – sLPO + carbonate + formate – sheep | + | **[[2ikc]] – sLPO + carbonate + formate – sheep<br /> |
| + | **[[7ve3]] - sLPO + hypoiodite + I<br /> | ||
*Lactoperoxidase quaternary complex | *Lactoperoxidase quaternary complex | ||
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**[[4ksz]] - bPLO + cystein + SCN + I<br /> | **[[4ksz]] - bPLO + cystein + SCN + I<br /> | ||
**[[5wv3]] - bPLO + oxidosulfanyl-methanamine + Br + I<br /> | **[[5wv3]] - bPLO + oxidosulfanyl-methanamine + Br + I<br /> | ||
| - | **[[ | + | **[[7dlq]] - bPLO + Br + Cl + SCN + I<br /> |
| - | **[[ | + | **[[7wyj]] - bPLO + indomethacin + SCN + I<br /> |
| - | **[[3py4]], [[ | + | **[[3py4]], [[6m7e]] - bPLO + paracetamol + SCN + I<br /> |
| - | **[[ | + | **[[7dn6]] - bPLO + phenyliso-SCN + SCN + I<br /> |
| - | **[[ | + | **[[7dn7]] - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I<br /> |
| - | **[[ | + | **[[8y9x]], [[4njb]], [[9m0i]] - bPLO + pyridine derivative + SCN + I<br /> |
**[[3r4x]], [[5zgs]] - bPLO + pyrazine derivative + SCN + I<br /> | **[[3r4x]], [[5zgs]] - bPLO + pyrazine derivative + SCN + I<br /> | ||
**[[3r5o]] - bPLO + methoxyphenol + SCN + I<br /> | **[[3r5o]] - bPLO + methoxyphenol + SCN + I<br /> | ||
**[[3tgy]] - bPLO + ascorbate + SCN + I<br /> | **[[3tgy]] - bPLO + ascorbate + SCN + I<br /> | ||
**[[3v6q]] - bPLO + CO + SCN + I<br /> | **[[3v6q]] - bPLO + CO + SCN + I<br /> | ||
| + | **[[6l9t]] - bLPO + Zn + OSCN + I<br /> | ||
| + | **[[5gls]] - bLPO + butyl-triazole + SCN + I<br /> | ||
| + | **[[5gh0]] - bLPO + mercaptoimidazole + nitrate + carbonate<br /> | ||
**[[2gjm]] - wbPLO + carbonate + SCN + I<br /> | **[[2gjm]] - wbPLO + carbonate + SCN + I<br /> | ||
**[[3faq]] – wbLPO + CN + SCN + I<br /> | **[[3faq]] – wbLPO + CN + SCN + I<br /> | ||
**[[3fnl]] - wbPLO + salicylhydroxamic acid + SCN + I<br /> | **[[3fnl]] - wbPLO + salicylhydroxamic acid + SCN + I<br /> | ||
| + | **[[4y55]] - wbLPO + rhodanide + SCN + I<br /> | ||
**[[2e9e]] – gPLO + nitrate + carbonate + SCN + CN<br /> | **[[2e9e]] – gPLO + nitrate + carbonate + SCN + CN<br /> | ||
**[[2efb]] – gPLO + phosphate + carbonate + SCN + CN<br /> | **[[2efb]] – gPLO + phosphate + carbonate + SCN + CN<br /> | ||
**[[3qf1]] - gPLO + piperazine + SCN + I<br /> | **[[3qf1]] - gPLO + piperazine + SCN + I<br /> | ||
| - | **[[ | + | **[[8ing]] - gPLO + acrylonitrile + SCN + I<br /> |
**[[4msf]], [[4oek]] - gPLO + phenol derivative+ SCN + I<br /> | **[[4msf]], [[4oek]] - gPLO + phenol derivative+ SCN + I<br /> | ||
**[[2eha]] – gPLO + formate + carbonate + SCN<br /> | **[[2eha]] – gPLO + formate + carbonate + SCN<br /> | ||
| - | **[[3r55]], [[ | + | **[[3r55]], [[6lf7]] - gPLO + pyrazine derivative + SCN + I<br /> |
**[[3sxv]] - gPLO + amitrole + SCN + I<br /> | **[[3sxv]] - gPLO + amitrole + SCN + I<br /> | ||
| - | **[[3r5q]] - sPLO +tetrahydrofuran + SCN + I<br /> | ||
**[[4qjq]] - gPLO + octopamine + SCN + I<br /> | **[[4qjq]] - gPLO + octopamine + SCN + I<br /> | ||
| - | **[[ | + | **[[6lf7]] - gPLO + hypocyanite + SCN + H2O2 + I<br /> |
| - | **[[ | + | **[[7ve3]] - sPLO +tetrahydrofuran + SCN + I<br /> |
| - | **[[ | + | **[[6ky7]], [[6l2j]] – yPLO + H2O2 + phosphoserine + SCN + I<br /> |
}} | }} | ||
Current revision
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3D structures of lactoperoxidase
Updated on 02-April-2025
References
- ↑ Gerson C, Sabater J, Scuri M, Torbati A, Coffey R, Abraham JW, Lauredo I, Forteza R, Wanner A, Salathe M, Abraham WM, Conner GE. The lactoperoxidase system functions in bacterial clearance of airways. Am J Respir Cell Mol Biol. 2000 Jun;22(6):665-71. PMID:10837362
- ↑ Gerson C, Sabater J, Scuri M, Torbati A, Coffey R, Abraham JW, Lauredo I, Forteza R, Wanner A, Salathe M, Abraham WM, Conner GE. The lactoperoxidase system functions in bacterial clearance of airways. Am J Respir Cell Mol Biol. 2000 Jun;22(6):665-71. PMID:10837362
- ↑ Sheikh IA, Singh AK, Singh N, Sinha M, Singh SB, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP. Structural evidence of substrate specificity in mammalian peroxidases: structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4 A resolution. J Biol Chem. 2009 May 29;284(22):14849-56. Epub 2009 Apr 1. PMID:19339248 doi:10.1074/jbc.M807644200
Proteopedia Page Contributors and Editors (what is this?)
Joel L. Sussman, Michal Harel, Alexander Berchansky, Jaime Prilusky
