Dihydrolipoamide dehydrogenase

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The regulation of Dihidrolipoamide dehydrogenase (E3) kinetically comes through regulation of the entire Pyruvate Dehydrogenase complex. As would be expected, one of the main regulators is the presence of its product, acetyl-CoA as well as NADH. This is through the E1 reaction of the complex, but necessarily effects the E3 reaction. However, the E1 portion of the complex is also regulated by phosphatase and kinase in phosphorylation and dephosphorylation reactions.‘<ref>Voet, Donald et al. 2008. Fundamentals of Biochemistry. 3rd ed. p.585</ref>’
The regulation of Dihidrolipoamide dehydrogenase (E3) kinetically comes through regulation of the entire Pyruvate Dehydrogenase complex. As would be expected, one of the main regulators is the presence of its product, acetyl-CoA as well as NADH. This is through the E1 reaction of the complex, but necessarily effects the E3 reaction. However, the E1 portion of the complex is also regulated by phosphatase and kinase in phosphorylation and dephosphorylation reactions.‘<ref>Voet, Donald et al. 2008. Fundamentals of Biochemistry. 3rd ed. p.585</ref>’
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</StructureSection>
 
==3D structures of dihydrolipoamide dehydrogenase==
==3D structures of dihydrolipoamide dehydrogenase==
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**[[1zmc]], [[1zmd]] – hDLD + NAD<br />
**[[1zmc]], [[1zmd]] – hDLD + NAD<br />
**[[6i4q]] – hDLD + FAD <br />
**[[6i4q]] – hDLD + FAD <br />
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**[[5j5z]], [[6hg8]], [[6i4p]], [[6i4r]], [[6i4s]], [[6i4t]], [[6i4u]], [[6i4z]] – hDLD (mutant) + FAD <br />
+
**[[5j5z]], [[6hg8]], [[6i4p]], [[6i4r]], [[6i4s]], [[6i4t]], [[6i4u]], [[6i4z]], [[7psc]], [[7zyt]] – hDLD (mutant) + FAD <br />
**[[2ii3]], [[2ii4]], [[2ii5]] – bDLD + CoA<br />
**[[2ii3]], [[2ii4]], [[2ii5]] – bDLD + CoA<br />
**[[1v59]] – yDLD + NAD<br />
**[[1v59]] – yDLD + NAD<br />
 +
**[[1lvl]] – PpDLD + NAD – ''Pseudomonas putida''<br />
 +
**[[6awa]] - PpDLD + FAD + AMP<br />
**[[3ii4]] – MtDLD + inhibitor <br />
**[[3ii4]] – MtDLD + inhibitor <br />
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**[[4m52]] – MtDLD + sulfonamide inhibitor<br />
+
**[[4m52]], [[8u0q]] – MtDLD + FAD + sulfonamide inhibitor<br />
 +
**[[8ct4]] – MtDLD + FAD + sulfonamide inhibitor – Cryo EM<br />
 +
**[[7kmy]] – MtDLD + FAD + pyridine inhibitor<br />
**[[1ebd]] – DLD + dihydrolipoamide acetyltransferase binding domain – ''Geobacillus stearothermophilus''<br />
**[[1ebd]] – DLD + dihydrolipoamide acetyltransferase binding domain – ''Geobacillus stearothermophilus''<br />
**[[4jdr]] – DLD + FAD – ''Escherichia coli''<br />
**[[4jdr]] – DLD + FAD – ''Escherichia coli''<br />
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**[[5u25]] – DLD + FAD – ''Neisseria gonorrhoeae''<br />
**[[5u25]] – DLD + FAD – ''Neisseria gonorrhoeae''<br />
**[[6aon]] – DLD + FAD – ''Bordetella pertussis''<br />
**[[6aon]] – DLD + FAD – ''Bordetella pertussis''<br />
 +
**[[6cmz]] – DLD + FAD + NAD – ''Burkholderia cenocepacia''<br />
 +
**[[6uzi]] – DLD + FAD – ''Elizabethkingia anophelis<''br />
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**[[6bz0]] – DLD + FAD – ''Acinetobacter baumannii''<br />
 +
**[[8ajj]] – DLD + FAD – ''Staphylococcus aureus<''br />
}}
}}
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

FAD-containing dihydrolipoamide dehydrogenase complexed with NAD 1lvl

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