1vfp

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[[Image:1vfp.jpg|left|200px]]
[[Image:1vfp.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1vfp |SIZE=350|CAPTION= <scene name='initialview01'>1vfp</scene>, resolution 2.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1vfp", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1vfp| PDB=1vfp | SCENE= }}
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|RELATEDENTRY=[[1su4|1SU4]], [[1iwo|1IWO]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vfp OCA], [http://www.ebi.ac.uk/pdbsum/1vfp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vfp RCSB]</span>
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}}
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'''Crystal structure of the SR CA2+-ATPase with bound AMPPCP'''
'''Crystal structure of the SR CA2+-ATPase with bound AMPPCP'''
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[[Category: Mizutani, T.]]
[[Category: Mizutani, T.]]
[[Category: Toyoshima, C.]]
[[Category: Toyoshima, C.]]
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[[Category: had fold]]
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[[Category: Had fold]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: p-type atpase]]
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[[Category: P-type atpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:29:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:23:47 2008''
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Revision as of 09:29, 3 May 2008

Image:1vfp.jpg

Template:STRUCTURE 1vfp

Crystal structure of the SR CA2+-ATPase with bound AMPPCP


Overview

P-type ATPases are ATP-powered ion pumps that establish ion concentration gradients across cell and organelle membranes. Here, we describe the crystal structure of the Ca2+ pump of skeletal muscle sarcoplasmic reticulum, a representative member of the P-type ATPase superfamily, with an ATP analogue, a Mg2+ and two Ca2+ ions in the respective binding sites. In this state, the ATP analogue reorganizes the three cytoplasmic domains (A, N and P), which are widely separated without nucleotide, by directly bridging the N and P domains. The structure of the P-domain itself is altered by the binding of the ATP analogue and Mg2+. As a result, the A-domain is tilted so that one of the transmembrane helices moves to lock the cytoplasmic gate of the transmembrane Ca2+-binding sites. This appears to be the mechanism for occluding the bound Ca2+ ions, before releasing them into the lumen of the sarcoplasmic reticulum.

About this Structure

1VFP is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the calcium pump with a bound ATP analogue., Toyoshima C, Mizutani T, Nature. 2004 Jul 29;430(6999):529-35. Epub 2004 Jun 30. PMID:15229613 Page seeded by OCA on Sat May 3 12:29:29 2008

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