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1vfy

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[[Image:1vfy.gif|left|200px]]
[[Image:1vfy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1vfy |SIZE=350|CAPTION= <scene name='initialview01'>1vfy</scene>, resolution 1.15&Aring;
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The line below this paragraph, containing "STRUCTURE_1vfy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= VPS27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1vfy| PDB=1vfy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vfy OCA], [http://www.ebi.ac.uk/pdbsum/1vfy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vfy RCSB]</span>
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}}
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'''PHOSPHATIDYLINOSITOL-3-PHOSPHATE BINDING FYVE DOMAIN OF VPS27P PROTEIN FROM SACCHAROMYCES CEREVISIAE'''
'''PHOSPHATIDYLINOSITOL-3-PHOSPHATE BINDING FYVE DOMAIN OF VPS27P PROTEIN FROM SACCHAROMYCES CEREVISIAE'''
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[[Category: Hurley, J H.]]
[[Category: Hurley, J H.]]
[[Category: Misra, S.]]
[[Category: Misra, S.]]
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[[Category: endosome maturation]]
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[[Category: Endosome maturation]]
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[[Category: fyve domain]]
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[[Category: Fyve domain]]
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[[Category: intracellular trafficking]]
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[[Category: Intracellular trafficking]]
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[[Category: transport protein]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:29:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:23:51 2008''
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Revision as of 09:29, 3 May 2008

Image:1vfy.gif

Template:STRUCTURE 1vfy

PHOSPHATIDYLINOSITOL-3-PHOSPHATE BINDING FYVE DOMAIN OF VPS27P PROTEIN FROM SACCHAROMYCES CEREVISIAE


Overview

Phosphatidylinositol 3-phosphate regulates membrane trafficking and signaling pathways by interacting with the FYVE domains of target proteins. The 1.15 A structure of the Vps27p FYVE domain reveals two antiparallel beta sheets and an alpha helix stabilized by two Zn2+-binding clusters. The core secondary structures are similar to a rabphilin-3A Zn2+-binding domain and to the C1 and LIM domains. Phosphatidylinositol 3-phosphate binds to a pocket formed by the (R/K)(R/K)HHCR motif. A lattice contact shows how anionic ligands can interact with the phosphatidylinositol 3-phosphate-binding site. The tip of the FYVE domain has basic and hydrophobic surfaces positioned so that nonspecific interactions with the phospholipid bilayer can abet specific binding to phosphatidylinositol 3-phosphate.

About this Structure

1VFY is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p., Misra S, Hurley JH, Cell. 1999 May 28;97(5):657-66. PMID:10367894 Page seeded by OCA on Sat May 3 12:29:53 2008

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