4ae4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:33, 9 April 2025) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4ae4.jpg|left|200px]]
 
-
<!--
+
==The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a novel SOUBA domain==
-
The line below this paragraph, containing "STRUCTURE_4ae4", creates the "Structure Box" on the page.
+
<StructureSection load='4ae4' size='340' side='right'caption='[[4ae4]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4ae4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AE4 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=MSO:SELENOMETHIONINE+SELENOXIDE'>MSO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
-
{{STRUCTURE_4ae4| PDB=4ae4 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ae4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae4 OCA], [https://pdbe.org/4ae4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ae4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ae4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ae4 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/UBAP1_HUMAN UBAP1_HUMAN]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The endosomal sorting complexes required for transport (ESCRTs) facilitate endosomal sorting of ubiquitinated cargo, MVB biogenesis, late stages of cytokinesis, and retroviral budding. Here we show that ubiquitin associated protein 1 (UBAP1), a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with Vps23/TSG101, VPS28, and VPS37. The X-ray crystal structure of the C-terminal region of UBAP1 reveals a domain that we describe as a solenoid of overlapping UBAs (SOUBA). NMR analysis shows that each of the three rigidly arranged overlapping UBAs making up the SOUBA interact with ubiquitin. We demonstrate that UBAP1-containing ESCRT-I is essential for degradation of antiviral cell-surface proteins, such as tetherin (BST-2/CD317), by viral countermeasures, namely, the HIV-1 accessory protein Vpu and the Kaposi sarcoma-associated herpesvirus (KSHV) ubiquitin ligase K5.
-
===The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a novel SOUBA domain===
+
The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain.,Agromayor M, Soler N, Caballe A, Kueck T, Freund SM, Allen MD, Bycroft M, Perisic O, Ye Y, McDonald B, Scheel H, Hofmann K, Neil SJ, Martin-Serrano J, Williams RL Structure. 2012 Mar 7;20(3):414-28. PMID:22405001<ref>PMID:22405001</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22405001}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 4ae4" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 22405001 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_22405001}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
[[4ae4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE4 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022405001</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Agromayor, M.]]
+
[[Category: Large Structures]]
-
[[Category: Allen, M D.]]
+
[[Category: Agromayor M]]
-
[[Category: Bycroft, M.]]
+
[[Category: Allen MD]]
-
[[Category: Caballe, A.]]
+
[[Category: Bycroft M]]
-
[[Category: Freund, S M.]]
+
[[Category: Caballe A]]
-
[[Category: Hofmann, K.]]
+
[[Category: Freund SM]]
-
[[Category: Kueck, T.]]
+
[[Category: Hofmann K]]
-
[[Category: Martin-Serrano, J.]]
+
[[Category: Kueck T]]
-
[[Category: Mcdonald, B.]]
+
[[Category: Martin-Serrano J]]
-
[[Category: Neil, S J.D.]]
+
[[Category: McDonald B]]
-
[[Category: Perisic, O.]]
+
[[Category: Neil SJD]]
-
[[Category: Scheel, H.]]
+
[[Category: Perisic O]]
-
[[Category: Soler, N.]]
+
[[Category: Scheel H]]
-
[[Category: Williams, R L.]]
+
[[Category: Soler N]]
-
[[Category: Ye, Y.]]
+
[[Category: Williams RL]]
-
[[Category: Endosomal sorting]]
+
[[Category: Ye Y]]
-
[[Category: Hiv-1]]
+
-
[[Category: Monoubiquitin]]
+
-
[[Category: Protein transport]]
+
-
[[Category: Tetherin]]
+
-
[[Category: Vpu]]
+

Current revision

The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a novel SOUBA domain

PDB ID 4ae4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ae4"
Personal tools