DNA damage-binding protein

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(New page: Crystal structure of human DDB1 and DDB2 complex with DNA 3ei1 {{STRUCTURE_3ei1| PDB=3ei1 | SIZE=350| SCENE= |right|CAPTION=Human DDB1 and DDB2 c...)
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<StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code [[3ei1]]).' scene='54/541124/Cv/1'>
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__TOC__
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== Function ==
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[[Image:3ei1.png|left|200px|thumb|Crystal structure of human DDB1 and DDB2 complex with DNA [[3ei1]]]]
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'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. <scene name='54/541124/Cv/2'>DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2</scene>.
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{{STRUCTURE_3ei1| PDB=3ei1 | SIZE=350| SCENE= |right|CAPTION=Human DDB1 and DDB2 complex with DNA [[3ei1]] }}
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DNA in this complex with DDB1 and DDB2 contains modified compounds <scene name='54/541124/Cv/5'>5PY and 64T</scene> (in darkmagenta and magenta, respectively), they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.<ref>PMID:18593899</ref><br /> Water molecules shown as red spheres.
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== Disease ==
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Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity.
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'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2.
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== 3D Structures of DNA damage-binding protein ==
== 3D Structures of DNA damage-binding protein ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[DNA damage-binding protein 3D structures]]
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===DDB1===
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[[2b5l]] – hDDB + simian virus 5 protein – human<br />
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[[2b5m]] – hDDB <br />
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[[2b5m]], [[2b5n]] – hDDB BPB domain<br />
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[[2hye]] – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1<br />
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[[3e0c]] – hDDB <br />
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[[3i7h]], [[3i7k]], [[3i7l]], [[3i7n]], [[3i7o]], [[3i7p]], [[3i89]], [[3i8c]], [[3i8e]] – hDDB + X protein peptide<br />
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[[4a11]] – hDDB + DNA excision repair protein ERCC-8<br />
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===DDB1+DDB2===
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[[3ei1]], [[3ei2]], [[4a08]], [[4a09]], [[4a0a]], [[4a0b]], [[4e54]], [[4e5z]] – hDDB + DNA<br />
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== References ==
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[[3ei3]], [[3ei4]] – hDDB <br />
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<references/>
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[[4a0k]] – hDDB + cullin-4A + ring-box protein 1<br />
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</StructureSection>
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[[4a0l]] – hDDB + cullin-4A + ring-box protein 1 + DNA<br />
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[[Category:Topic Page]]

Current revision

Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code 3ei1).

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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