DNA damage-binding protein
From Proteopedia
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<StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code [[3ei1]]).' scene='54/541124/Cv/1'> | <StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code [[3ei1]]).' scene='54/541124/Cv/1'> | ||
| + | __TOC__ | ||
== Function == | == Function == | ||
'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. <scene name='54/541124/Cv/2'>DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2</scene>. | '''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. <scene name='54/541124/Cv/2'>DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2</scene>. | ||
| - | DNA in this complex with DDB1 and DDB2 contains modified compounds <scene name='54/541124/Cv/5'>5PY and 64T</scene>, they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.<ref>PMID:18593899</ref><br /> | + | DNA in this complex with DDB1 and DDB2 contains modified compounds <scene name='54/541124/Cv/5'>5PY and 64T</scene> (in darkmagenta and magenta, respectively), they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.<ref>PMID:18593899</ref><br /> Water molecules shown as red spheres. |
== Disease == | == Disease == | ||
Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity. | Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity. | ||
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== 3D Structures of DNA damage-binding protein == | == 3D Structures of DNA damage-binding protein == | ||
| - | + | [[DNA damage-binding protein 3D structures]] | |
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| - | *DDB1 | ||
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| - | **[[2b5l]] – hDDB + simian virus 5 protein – human<br /> | ||
| - | **[[2b5m]] – hDDB <br /> | ||
| - | **[[2b5m]], [[2b5n]] – hDDB BPB domain<br /> | ||
| - | **[[2hye]] – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1<br /> | ||
| - | **[[3e0c]] – hDDB <br /> | ||
| - | **[[3i7h]], [[3i7k]], [[3i7l]], [[3i7n]], [[3i7o]], [[3i7p]], [[3i89]], [[3i8c]], [[3i8e]] – hDDB + X protein peptide<br /> | ||
| - | **[[4a11]] – hDDB + DNA excision repair protein ERCC-8<br /> | ||
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| - | *DDB1+DDB2 | ||
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| - | **[[3ei1]], [[3ei2]], [[4a08]], [[4a09]], [[4a0a]], [[4a0b]], [[4e54]], [[4e5z]] – hDDB + DNA<br /> | ||
| - | **[[3ei3]], [[3ei4]] – hDDB <br /> | ||
| - | **[[4a0k]] – hDDB + cullin-4A + ring-box protein 1<br /> | ||
| - | **[[4a0l]] – hDDB + cullin-4A + ring-box protein 1 + DNA<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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