DNA damage-binding protein
From Proteopedia
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<StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code [[3ei1]]).' scene='54/541124/Cv/1'> | <StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code [[3ei1]]).' scene='54/541124/Cv/1'> | ||
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== Function == | == Function == | ||
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Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity. | Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity. | ||
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== 3D Structures of DNA damage-binding protein == | == 3D Structures of DNA damage-binding protein == | ||
| - | + | [[DNA damage-binding protein 3D structures]] | |
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| - | *DDB1 | ||
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| - | **[[3e0c]] – hDDB - human<br /> | ||
| - | **[[2b5m]], [[2b5n]] – hDDB BPB domain<br /> | ||
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| - | *DDB1 binary complex | ||
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| - | **[[2b5l]] – hDDB + simian virus 5 protein <br /> | ||
| - | **[[3i7h]], [[3i7k]], [[3i7l]], [[3i7n]], [[3i7o]], [[3i7p]], [[3i89]], [[3i8c]], **[[3i8e]] – hDDB + X protein peptide<br /> | ||
| - | **[[6dsz]] – hDDB + DET1 peptide<br /> | ||
| - | **[[4a11]], [[6fcv]] – hDDB + DNA excision repair protein ERCC-8<br /> | ||
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| - | *DDB1 ternary complex | ||
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| - | **[[4ci1]], [[4ci2]], [[4ci3]], [[4tz4]] – hDDB + cereblon + thalidomide derivative<br /> | ||
| - | **[[5v3o]] – hDDB + cereblon + piperidine derivative<br /> | ||
| - | **[[5fqd]] – hDDB + cereblon + casein kinase 1<br /> | ||
| - | **[[5hxb]] – hDDB + cereblon + ERF3A<br /> | ||
| - | **[[6bn8]], [[6bn9]], [[6bnb]], [[6boy]] – hDDB + cereblon + BRD4<br /> | ||
| - | **[[6h0f]] – hDDB (mutant) + cereblon + IKAROS<br /> | ||
| - | **[[6h0g]] – hDDB (mutant) + cereblon + ZNF692<br /> | ||
| - | **[[6td3]] – hDDB + cyclin-dependent kinase 12 + cyclin-K<br /> | ||
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| - | *DDB1 quaternary complex | ||
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| - | **[[6uml]] – hDDB + cereblon + ZNF797 + thalidomide derivative <br /> | ||
| - | **[[2hye]] – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1<br /> | ||
| - | **[[6pai]], [[6q0r]], [[6ue5]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + sulfonamide derivative<br /> | ||
| - | **[[6q0v]], [[6q0w]], [[6ud7]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + anti-cancer drug<br /> | ||
| - | **[[6sj7]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + anti-cancer drug – Cryo EM<br /> | ||
| - | **[[5jk7]] – hDDB + VPRBP + uracil-DNA glycosylase + VPR<br /> | ||
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| - | *DDB1+DDB2 | ||
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| - | **[[3ei3]], [[3ei4]] – hDDB <br /> | ||
| - | **[[3ei1]], [[3ei2]], [[4a08]], [[4a09]], [[4a0a]], [[4a0b]], [[4e54]], [[4e5z]] – hDDB + DNA<br /> | ||
| - | **[[4a0k]] – hDDB + cullin-4A + ring-box protein 1<br /> | ||
| - | **[[4a0l]] – hDDB + cullin-4A + ring-box protein 1 + DNA<br /> | ||
| - | **[[6r8y]], [[6r8z]], [[6r90]], [[6r91]], [[6r92]] – hDDB + histones + DNA – Cryo EM<br /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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