DNA methyltransferase 3D structures
From Proteopedia
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**[[1eh8]] - hO6-methylguanine DNMT benzylated<br /> | **[[1eh8]] - hO6-methylguanine DNMT benzylated<br /> | ||
**[[1mgt]] - O6-methylguanine DNMT – ''Thermococcus kodakarensis''<br /> | **[[1mgt]] - O6-methylguanine DNMT – ''Thermococcus kodakarensis''<br /> | ||
| - | **[[1wrj]] - O6-methylguanine DNMT - ''Sulfolobus tokodaii'' | + | **[[1wrj]], [[7dkn]] - O6-methylguanine DNMT - ''Sulfolobus tokodaii''<br /> |
| - | + | **[[7csm]], [[7d4v]], [[7dqr]], [[7dqt]] - StO6-methylguanine DNMT (mutant) <br /> | |
| + | **[[7e1p]] - StO6-methylguanine DNMT (mutant) + purine derivative<br /> | ||
| + | **[[7dqq]] - StO6-methylguanine DNMT (mutant) + methyldeoxyguanosine<br /> | ||
**[[2g7h]] - O6-methylguanine DNMT – ''Methanocaldococcus jannaschii'' | **[[2g7h]] - O6-methylguanine DNMT – ''Methanocaldococcus jannaschii'' | ||
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**[[2kif]], [[2kim]] - O6-methylguanine DNMT – ''Vibrio parahaemolyticus'' - NMR<br /> | **[[2kif]], [[2kim]] - O6-methylguanine DNMT – ''Vibrio parahaemolyticus'' - NMR<br /> | ||
**[[4bhb]], [[4bhc]], [[4wxd]], [[4wxc]] - MtO6-methylguanine DNMT (mutant) – ''Mycobacterium tuberculosis''<br /> | **[[4bhb]], [[4bhc]], [[4wxd]], [[4wxc]] - MtO6-methylguanine DNMT (mutant) – ''Mycobacterium tuberculosis''<br /> | ||
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**[[1sfe]] – O6-methylguanine DNMT C terminal – ''Escherichia coli''<br /> | **[[1sfe]] – O6-methylguanine DNMT C terminal – ''Escherichia coli''<br /> | ||
| - | *Methylcytosine DNMT; Domains – RFTS 351-599; ADD 476-611; PWWP 206-355 | + | *Methylcytosine DNMT; Domains – N-terminal 16-93; RFTS 351-599; ADD 476-611; PWWP 206-355; methyltransferase 628-912 |
| + | **[[8v9u]] - h-cytosine DNMT 1 N-terminal domain - NMR<br /> | ||
**[[3epz]] - h-cytosine DNMT 1 RFTS domain<br /> | **[[3epz]] - h-cytosine DNMT 1 RFTS domain<br /> | ||
**[[1g55]] - h-cytosine DNMT 2 (mutant) <br /> | **[[1g55]] - h-cytosine DNMT 2 (mutant) <br /> | ||
**[[2qrv]] - h-cytosine DNMT 3A C-terminal domain<br /> | **[[2qrv]] - h-cytosine DNMT 3A C-terminal domain<br /> | ||
| - | **[[3a1a]] - h-cytosine DNMT 3A ADD domain<br /> | + | **[[3a1a]], [[8ba5]] - h-cytosine DNMT 3A ADD domain<br /> |
| - | **[[3flg]] - h-cytosine DNMT 3B PWWP domain<br /> | + | **[[8tdr]] - h-cytosine DNMT 3A methyltransferase domain<br /> |
| + | **[[8te1]], [[8te3]], [[8te4]] - h-cytosine DNMT 3A methyltransferase domain (mutant)<br /> | ||
| + | **[[7v0e]] - h-cytosine DNMT 3B methyltransferase domain<br /> | ||
| + | **[[7o45]] - h-cytosine DNMT 3B ADD domain<br /> | ||
| + | **[[3flg]], [[8zlk]], - h-cytosine DNMT 3B PWWP domain<br /> | ||
**[[3qkj]] - h-cytosine DNMT 3B residues 293-442<br /> | **[[3qkj]] - h-cytosine DNMT 3B residues 293-442<br /> | ||
**[[3av4]], [[1khc]] - m-cytosine DNMT residues 291-1620 – mouse<br /> | **[[3av4]], [[1khc]] - m-cytosine DNMT residues 291-1620 – mouse<br /> | ||
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**[[6pa7]] - h-cytosine DNMT 3A residues 224-912 + h-cytosine DNMT 3B residues 1-770 + SAH + histones + DNA – Cryo EM<br /> | **[[6pa7]] - h-cytosine DNMT 3A residues 224-912 + h-cytosine DNMT 3B residues 1-770 + SAH + histones + DNA – Cryo EM<br /> | ||
| - | **[[6w89]], [[6w8b]], [[6w8d]], [[ | + | **[[6w89]], [[6w8b]], [[6w8d]], [[6w8j]] - h-cytosine DNMT 3A residues 628-912 (mutant) + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor<br /> |
**[[6f57]], [[5yx2]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative<br /> | **[[6f57]], [[5yx2]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative<br /> | ||
**[[6brr]] - h-cytosine DNMT 3A residues 439-723 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative<br /> | **[[6brr]] - h-cytosine DNMT 3A residues 439-723 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative<br /> | ||
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**[[5ydr]] - h-cytosine DNMT 1 RFTS domain + ubiquitin<br /> | **[[5ydr]] - h-cytosine DNMT 1 RFTS domain + ubiquitin<br /> | ||
**[[5wvo]] - h-cytosine DNMT 1 RFTS domain + ubiquitin + histone H3.1<br /> | **[[5wvo]] - h-cytosine DNMT 1 RFTS domain + ubiquitin + histone H3.1<br /> | ||
| + | **[[8xqc]] - h-cytosine DNMT 1 351-1616 + ubiquitin + PAF15 + DNA – Cryo EM<br /> | ||
| + | **[[7xi9]] – hDNMT 1 351-1600 + H3 – Cryo EM <BR /> | ||
**[[3a1b]], [[4qbq]] - h-cytosine DNMT 3A ADD domain + histone H3 | **[[3a1b]], [[4qbq]] - h-cytosine DNMT 3A ADD domain + histone H3 | ||
**[[4qbr]], [[4qbs]] - h-cytosine DNMT 3A ADD domain (mutant) + histone H3<br /> | **[[4qbr]], [[4qbs]] - h-cytosine DNMT 3A ADD domain (mutant) + histone H3<br /> | ||
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3L residues 178-379 + histone 3.3 peptide + SAH<br /> | **[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3L residues 178-379 + histone 3.3 peptide + SAH<br /> | ||
| - | **[[ | + | **[[8uw1]] - h-cytosine DNMT 3A residues 159-228 in nucleosome – Cryo EM<br /> |
| + | **[[5ciu]], [[5ciy]] - h-cytosine DNMT 3B PWWP domain + histone H3.2<br /> | ||
**[[6pzv]] – b-cytosine DNMT 1 RFTS domain + histone H3.3 + ubiquitin - bovine<br /> | **[[6pzv]] – b-cytosine DNMT 1 RFTS domain + histone H3.3 + ubiquitin - bovine<br /> | ||
**[[7lmk]], [[7lmm]] – b-cytosine DNMT 1 BAH1 domain + histone H4 <br /> | **[[7lmk]], [[7lmm]] – b-cytosine DNMT 1 BAH1 domain + histone H4 <br /> | ||
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**[[4wxx]] - h-cytosine DNMT 1 residues 351-1600 + SAH<br /> | **[[4wxx]] - h-cytosine DNMT 1 residues 351-1600 + SAH<br /> | ||
| + | **[[7sfc]], [[7sfd]], [[7sfe]], [[7sff]], [[7sfg]] – hDNMT 1 729-1600 + DNA + CMP + pyrimidine derivative + SAM <BR /> | ||
| + | **[[6x9j]], [[6x9k]], [[6x9i]] – hDNMT 1 729-1600 + DNA + CMP + pyrimidine derivative + SAH <BR /> | ||
| + | **[[7xi9]] – hDNMT 1 351-1600 + H3 – Cryo EM <BR /> | ||
**[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3L residues 178-379 + SAH<br /> | **[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3L residues 178-379 + SAH<br /> | ||
**[[5nvo]] - h-cytosine DNMT 3B PWWP domain + choline<br /> | **[[5nvo]] - h-cytosine DNMT 3B PWWP domain + choline<br /> | ||
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**[[6kdp]] - h-cytosine DNMT 3B residues 563-853 + h-cytosine DNMT 3L residues 178-386 + SAH <br /> | **[[6kdp]] - h-cytosine DNMT 3B residues 563-853 + h-cytosine DNMT 3L residues 178-386 + SAH <br /> | ||
**[[6kdt]] - h-cytosine DNMT 3B residues 563-853 (mutant) + h-cytosine DNMT 3L residues 178-386 + SAH <br /> | **[[6kdt]] - h-cytosine DNMT 3B residues 563-853 (mutant) + h-cytosine DNMT 3L residues 178-386 + SAH <br /> | ||
| + | **[[8eih]], [[8eii]], [[8eij]], [[8eik]] - h-cytosine DNMT 3B residues 206-853 + SAH – Cryo EM<br /> | ||
| + | **[[7x9d]] - h-cytosine DNMT 3B residues 571-853 + harmine<br /> | ||
| + | **[[8xee]] - h-cytosine DNMT 3B residues 571-853 (mutant) + SAH<br /> | ||
**[[3swr]] - h-cytosine DNMT + sinefungin<br /> | **[[3swr]] - h-cytosine DNMT + sinefungin<br /> | ||
**[[6w8v]], [[6w8w]] - m-cytosine DNMT1 residues 731-1600 + SAH + CMP derivative<br /> | **[[6w8v]], [[6w8w]] - m-cytosine DNMT1 residues 731-1600 + SAH + CMP derivative<br /> | ||
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**[[6khs]] – hN6AMT1 + TRMT112 + SAH + methylGln<br /> | **[[6khs]] – hN6AMT1 + TRMT112 + SAH + methylGln<br /> | ||
**[[1nw5]] – RsN6-adenine DNMT + SAM – ''Rhodobacter sphaeroides'' | **[[1nw5]] – RsN6-adenine DNMT + SAM – ''Rhodobacter sphaeroides'' | ||
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**[[1nw6]] - RsN6-adenine DNMT + sinefungin<br /> | **[[1nw6]] - RsN6-adenine DNMT + sinefungin<br /> | ||
**[[1nw7]] - RsN6-adenine DNMT + SAH<br /> | **[[1nw7]] - RsN6-adenine DNMT + SAH<br /> | ||
**[[1nw8]] - RsN6-adenine DNMT (mutant)<br /> | **[[1nw8]] - RsN6-adenine DNMT (mutant)<br /> | ||
**[[5hek]] - HpN6-adenine DNMT – ''Helicobacter pylori''<br /> | **[[5hek]] - HpN6-adenine DNMT – ''Helicobacter pylori''<br /> | ||
| - | **[[5hfj]] | + | **[[5hfj]], [[6k0x]] - HpN6-adenine DNMT + sinefungin<br /> |
| - | + | ||
**[[2ibs]], [[2ibt]], [[2ih2]], [[2ih4]], [[2ih5]], [[2np6]], [[2np7]], [[1g38]] - Ta-adenine DNMT Taqi + DNA + cofactor analog – ''Thermus aquaticus''<br /> | **[[2ibs]], [[2ibt]], [[2ih2]], [[2ih4]], [[2ih5]], [[2np6]], [[2np7]], [[1g38]] - Ta-adenine DNMT Taqi + DNA + cofactor analog – ''Thermus aquaticus''<br /> | ||
**[[1aqi]] – Ta-adenine DNMT Taqi + SAH<br /> | **[[1aqi]] – Ta-adenine DNMT Taqi + SAH<br /> | ||
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**[[7m6b]] - adenine DNMT + SAM + SAH – ''Caldicellulosiraptor bescii''<br /> | **[[7m6b]] - adenine DNMT + SAM + SAH – ''Caldicellulosiraptor bescii''<br /> | ||
**[[7lni]], [[7lnj]] – Cd-adenine DNMT + DNA – ''Clostridioides difficile''<br /> | **[[7lni]], [[7lnj]] – Cd-adenine DNMT + DNA – ''Clostridioides difficile''<br /> | ||
| - | **[[7lnj]] – Cd-adenine DNMT + DNA + SAH<br /> | + | **[[7lnj]], [[7lt5]] – Cd-adenine DNMT + DNA + SAH<br /> |
| + | **[[7rfk]], [[7rfl]], [[7rfm]], [[7rfn]], [[8cy2]], [[8fs1]], [[8fs2]] – Cd-adenine DNMT + DNA + inhibitor<br /> | ||
| + | **[[8cxs]], [[8cxt]], [[8cxu]], [[8cxv]], [[8cxw]], [[8cxx]], [[8cxy]], [[8cxz]], [[8cy0]], [[8cy1]], [[8cy2j]], [[8cy3]], [[8cy4]], [[8cy5]] – Cd-adenine DNMT + DNA + inhibitor<br /> | ||
**[[7lo5]], [[7lvv]] - adenine DNMT + DNA + SAM – ''Deinococcus wulumuquiensis'' – Cryo EM<br /> | **[[7lo5]], [[7lvv]] - adenine DNMT + DNA + SAM – ''Deinococcus wulumuquiensis'' – Cryo EM<br /> | ||
| + | **[[7qw5]], [[7qw6]], [[7qw7]], [[7qw8]] – adenine DNMT + DNA + SAH – ''Geobacillus stearothermophilus''<br /> | ||
| + | **[[7vru]], [[7vs4]] – adenine DNMT + DNA + AMP + SAH – ''Pseudomonas alcaligenes''<br /> | ||
| + | **[[8q56]] – adenine DNMT + OCR + SAM – ''Salmonella enterica'' <br /> | ||
*HhaI DNA methyltransferase | *HhaI DNA methyltransferase | ||
| + | **[[5lod]] – HhHDMT <BR /> | ||
**[[1fjx]], [[2hmy]] – HhHDMT + SAM – ''Haemophilus haemolyticus'' <BR /> | **[[1fjx]], [[2hmy]] – HhHDMT + SAM – ''Haemophilus haemolyticus'' <BR /> | ||
**[[1svu]] – HhHDMT (mutant) + SAH <BR /> | **[[1svu]] – HhHDMT (mutant) + SAH <BR /> | ||
Current revision
3D Structures of DNA methyltransferase
Updated on 20-April-2025
