8oz4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Populus tremula stable protein 1 with an alternate crystal lattice== | |
| + | <StructureSection load='8oz4' size='340' side='right'caption='[[8oz4]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8oz4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Populus_tremula Populus tremula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OZ4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oz4 OCA], [https://pdbe.org/8oz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oz4 RCSB], [https://www.ebi.ac.uk/pdbsum/8oz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oz4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9AR79_POPTN Q9AR79_POPTN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Enzymes have gained their unique efficiency and catalytic activity through billions of years of evolution, perfecting their active site to a desired reaction. Inspired by nature, a novel enzyme-mimicking platform is designed based on stable protein 1 (SP1) to create a nano-compartment that mimics peroxidase activity. The biohybrid reveals enhanced activity over the hemin cofactor alone and improved stability in organic solvents in comparison to native peroxidase. Furthermore, the utilization of the obtained biohybrid in an optical glucose biosensing platform is shown. The biohybrid crystallographic structure is solved, indicating that the SP1 structure is not affected by the hemin coordination. This work opens the path for developing new cofactor binding centers in engineered protein scaffolds for various artificial catalytic processes. | ||
| - | + | A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties.,Zeibaq Y, Bachar O, Sklyar J, Adir N, Yehezkeli O Small Sci. 2024 Mar 19;4(6):2400025. doi: 10.1002/smsc.202400025. eCollection , 2024 Jun. PMID:40212758<ref>PMID:40212758</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8oz4" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Populus tremula]] | ||
| + | [[Category: Adir N]] | ||
| + | [[Category: Bachar O]] | ||
| + | [[Category: Sklyar J]] | ||
| + | [[Category: Yehezkeli O]] | ||
| + | [[Category: Zeibaq Y]] | ||
Current revision
Populus tremula stable protein 1 with an alternate crystal lattice
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