User:Jacob A. Ray/Sandbox 1
From Proteopedia
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==CD44== | ==CD44== | ||
<StructureSection load='4pz4' size='340' side='right' caption='Hyaluronan Binding Domain of Human CD44 (pdb: 4pz4)' scene=''> | <StructureSection load='4pz4' size='340' side='right' caption='Hyaluronan Binding Domain of Human CD44 (pdb: 4pz4)' scene=''> | ||
| - | This is a default text for your page '''Jacob A. Ray/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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== Function == | == Function == | ||
| - | CD44 is a highly glycosylated multifunctional cell surface receptor<ref>DOI 10. | + | CD44 is a highly glycosylated multifunctional cell surface receptor that is involved in cell-cell interaction and maintenance of the extracellular matrix.<ref>DOI 10.3389/fcell.2017.00018</ref> The primary ligand for CD44 is hyaluronan (HA) <ref> DOI 10.1016/S1097-2765(04)00080-2</ref> but it has also been found to interact with other molecules including osteopontin (OPN), collagens, and fibronectin. <ref>DOI 10.1136/mp.52.4.189</ref> |
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| - | <!-- The content below was inserted by the ConSurf template --> | ||
| - | == Evolutionary Conservation == | ||
| - | [[Image:Consurf_key_small.gif|right|200px]] | ||
| - | Check | ||
| - | <jmol> | ||
| - | <jmolCheckbox> | ||
| - | <scriptWhenChecked> | ||
| - | select protein; define ~consurf_to_do selected; | ||
| - | consurf_initial_scene = true; | ||
| - | script /wiki/ConSurf/pz/4pz4_consurf.spt; | ||
| - | </scriptWhenChecked> | ||
| - | <scriptWhenUnchecked> | ||
| - | script /wiki/extensions/Proteopedia/spt/initialview01.spt; | ||
| - | </scriptWhenUnchecked> | ||
| - | <text>to colour the structure by Evolutionary Conservation</text> | ||
| - | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. | ||
| - | You may read the [[Conservation%2C_Evolutionary|explanation]] | ||
| - | of the method and the full data available from | ||
| - | [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4pz4 ConSurf]. | ||
| - | <!-- end of content inserted by the ConSurf template --> | ||
== Isoforms == | == Isoforms == | ||
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== Cancer == | == Cancer == | ||
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| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 22:57, 29 April 2025
CD44
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References
- ↑ Senbanjo LT, Chellaiah MA. CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells. Front Cell Dev Biol. 2017 Mar 7;5:18. PMID:28326306 doi:10.3389/fcell.2017.00018
- ↑ doi: https://dx.doi.org/10.1016/S1097-2765(04)00080-2
- ↑ Goodison S, Urquidi V, Tarin D. CD44 cell adhesion molecules. Mol Pathol. 1999 Aug;52(4):189-96. PMID:10694938 doi:10.1136/mp.52.4.189
