User:Jacob A. Ray/Sandbox 1
From Proteopedia
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<StructureSection load='4pz4' size='340' side='right' caption='Hyaluronan Binding Domain of Human CD44 (pdb: 4pz4)' scene=''> | <StructureSection load='4pz4' size='340' side='right' caption='Hyaluronan Binding Domain of Human CD44 (pdb: 4pz4)' scene=''> | ||
== Function == | == Function == | ||
| - | CD44 is a highly glycosylated multifunctional cell surface receptor that is involved in cell-cell interaction and maintenance of the extracellular matrix.<ref>DOI 10.3389/fcell.2017.00018</ref> The primary ligand for CD44 is hyaluronan (HA), | + | CD44 is a highly glycosylated multifunctional cell surface receptor that is involved in cell-cell interaction and maintenance of the extracellular matrix.<ref>DOI 10.3389/fcell.2017.00018</ref> The primary ligand for CD44 is hyaluronan (HA), but it has also been found to interact with other molecules including osteopontin (OPN), collagens, and fibronectin. <ref>DOI 10.1136/mp.52.4.189</ref> CD44 is a single chain protein containing four distinct regions: the N-terminal HA binding Link domain<ref>DOI 10.1016/S1097-2765(04)00080-2</ref>, a flexible variable domain, a transmembrane domain, and an intracellular signaling domain.<ref>DOI 10.3389/fcell.2017.00018</ref> |
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| + | == Sequence Conservation == | ||
== Isoforms == | == Isoforms == | ||
Revision as of 01:28, 30 April 2025
CD44
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References
- ↑ Senbanjo LT, Chellaiah MA. CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells. Front Cell Dev Biol. 2017 Mar 7;5:18. PMID:28326306 doi:10.3389/fcell.2017.00018
- ↑ Goodison S, Urquidi V, Tarin D. CD44 cell adhesion molecules. Mol Pathol. 1999 Aug;52(4):189-96. PMID:10694938 doi:10.1136/mp.52.4.189
- ↑ doi: https://dx.doi.org/10.1016/S1097-2765(04)00080-2
- ↑ Senbanjo LT, Chellaiah MA. CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells. Front Cell Dev Biol. 2017 Mar 7;5:18. PMID:28326306 doi:10.3389/fcell.2017.00018
