9o9n

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m (Protected "9o9n" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 9o9n is ON HOLD
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==Crystal structure of PPARgamma ligand binding domain (LBD) in complex with NCoR1 corepressor peptide and inverse agonist FX-909==
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<StructureSection load='9o9n' size='340' side='right'caption='[[9o9n]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: Laughlin, Z.T., Dong, J., Harp, J.M., Kojetin, D.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9o9n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O9N FirstGlance]. <br>
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Description: Crystal structure of human PPARg ligand binding domain in complex with NCoR-ID2 corepressor peptide and inverse agonist FX-909
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CAA:3-[5,7-bis(fluoranyl)-4-oxidanylidene-1~{H}-quinolin-2-yl]-4-methylsulfonyl-benzenecarbonitrile'>A1CAA</scene></td></tr>
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[[Category: Laughlin, Z.T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o9n OCA], [https://pdbe.org/9o9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o9n RCSB], [https://www.ebi.ac.uk/pdbsum/9o9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o9n ProSAT]</span></td></tr>
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[[Category: Dong, J]]
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</table>
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[[Category: Kojetin, D.J]]
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== Disease ==
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[[Category: Harp, J.M]]
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[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
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== Function ==
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[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Dong J]]
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[[Category: Harp JM]]
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[[Category: Kojetin DJ]]
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[[Category: Laughlin ZT]]

Revision as of 05:48, 14 May 2025

Crystal structure of PPARgamma ligand binding domain (LBD) in complex with NCoR1 corepressor peptide and inverse agonist FX-909

PDB ID 9o9n

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