8wsa
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM Structure of Mouse TLR4/MD-2/DLAM5 Complex== | |
| - | + | <StructureSection load='8wsa' size='340' side='right'caption='[[8wsa]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8wsa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WSA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0IL:(3R)-3-tetradecanoyloxytetradecanoic+acid'>0IL</scene>, <scene name='pdbligand=2IL:(3R)-3-(dodecanoyloxy)tetradecanoic+acid'>2IL</scene>, <scene name='pdbligand=A1L01:(3~{S})-3-decanoyloxytetradecanoic+acid'>A1L01</scene>, <scene name='pdbligand=GP4:GLUCOSAMINE+4-PHOSPHATE'>GP4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=X6N:[(2~{R},3~{S},4~{R},5~{S})-2-(hydroxymethyl)-5-methoxy-4,6-bis(oxidanyl)oxan-3-yl]+dihydrogen+phosphate'>X6N</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wsa OCA], [https://pdbe.org/8wsa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wsa RCSB], [https://www.ebi.ac.uk/pdbsum/8wsa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wsa ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LY96_MOUSE LY96_MOUSE] Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Fu Y]] | ||
| + | [[Category: Kim H]] | ||
| + | [[Category: Kim HM]] | ||
Current revision
Cryo-EM Structure of Mouse TLR4/MD-2/DLAM5 Complex
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Categories: Large Structures | Mus musculus | Fu Y | Kim H | Kim HM
