Factor inhibiting HIF

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:52, 5 June 2025) (edit) (undo)
 
(21 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_1mzf| PDB=1mzf | SIZE=400| SCENE= |right|CAPTION=Monomer of the dimeric factor inhibiting HIF complex with oxogluterate derivative, [[1mzf]] }}
+
<StructureSection load='1mzf' size='350' side='right' scene='48/480806/Cv/1' caption='Dimeric factor inhibiting HIF complex with oxogluterate derivative (PDB code [[1mzf]]) '>
-
For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen.
 
-
{{TOC limit|limit=2}}
+
For details on '''Factor inhibiting HIF''' or '''Hypoxia-inducible factor 1-alpha inhibitor''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/5'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>.
 +
<scene name='48/480806/Cv/6'>Fe/2-oxogluterate binding site</scene> (PDB code [[1mzf]]).<ref>PMID:12432100</ref>
 +
</StructureSection>
== 3D Structures of factor inhibiting HIF ==
== 3D Structures of factor inhibiting HIF ==
-
''Update June 2012''
+
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
[[1mze]], [[1h2n]], [[1iz3]] – hFIH1α – human
+
*FIH1α
-
===FIH1α complex with small molecule===
+
**[[1mze]], [[1h2n]], [[1iz3]] – hFIH1α – human
-
[[1yci]], [[3od4]], [[2yc0]], [[2yde]]– hFIH1α + inhibitor<br />
+
*FIH1α complex with small molecule
-
[[2w0x]] - hFIH1α + pyridine derivative<br />
+
-
[[2cgn]] – hFIH1α + succinate<br />
+
-
[[2cgo]] – hFIH1α + fumarate<br />
+
-
[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br />
+
-
[[3kcx]], [[3kcy]], [[3od4]] - hFIH1α + quinol derivative<br />
+
-
===FIH1α complex with polypeptide===
+
**[[1yci]], [[3od4]], [[2yc0]], [[2yde]], [[5op6]], [[5op8]], [[5opc]], [[8ihz]], [[8ii0]], [[8k71]], [[8k72]], [[8k73]], [[9i4h]] – hFIH1α + inhibitor<br />
 +
**[[2w0x]] - hFIH1α + pyridine derivative<br />
 +
**[[2cgn]] – hFIH1α + succinate<br />
 +
**[[2cgo]] – hFIH1α + fumarate<br />
 +
**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]], [[4z2w]], [[5jwk]], [[7a1j]], [[7a1k]], [[7a1l]], [[7a1m]] – hFIH1α + oxoglutarate derivative<br />
 +
**[[5jwk]], [[5jwl]] - hFIH1α (mutant) + ketoglutarate<br />
 +
**[[3kcx]], [[3kcy]], [[3od4]], [[4bio]], [[9jtx]] - hFIH1α + quinol derivative<br />
 +
**[[4ai8]] - hFIH1α + daminozide<br />
 +
**[[4z1v]] - hFIH1α + oxalylglycine + NO<br />
 +
**[[9fsn]], [[9iif]] - hFIH1α + anemia drug<br />
-
[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
+
*FIH1α complex with polypeptide
-
[[2ilm]], [[3d8c]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
+
-
[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
+
-
[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />
+
-
[[2y0i]] - hFIH1α + tankyrase 2 peptide<br />
+
-
[[3hqr]], [[3hqu]] - hFIH 1α C terminal + EGL nine homolog<br />
+
-
[[1lqb]], [[1lm8]] - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL<br />
+
-
[[1l3e]] - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR<br />
+
-
[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger
+
-
===FIH2α===
+
**[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
 +
**[[2ilm]], [[3d8c]], [[5jwp]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
 +
**[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
 +
**[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />
 +
**[[2y0i]] - hFIH1α + tankyrase 2 peptide<br />
 +
**[[3hqr]], [[3hqu]] - hFIH 1α C terminal + EGL nine homolog<br />
 +
**[[1lqb]], [[1lm8]] - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL<br />
 +
**[[1l3e]] - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR<br />
 +
**[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br />
 +
**[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br />
 +
**[[4b7e]], [[4b7k]], [[4jaa]], [[4nr1]], [[7a1q]] - hFIH1α + consensus ankyrin repeat peptide<br />
 +
**[[7a1n]], [[7a1o]], [[7a1p]], [[7a1s]] - hFIH1α + consensus ankyrin repeat peptide + oxoglutarate derivative <br />
 +
**[[6h9j]], [[6ha6]] - hFIH1α + TRPV3 peptide + oxalylglycine<br />
 +
**[[6hc8]] - hFIH1α + TRPA1 peptide + oxalylglycine<br />
 +
**[[6hl6]] - hFIH1α + ASPP peptide + oxalylglycine<br />
 +
**[[6hl5]] - hFIH1α + ASPP1 peptide + oxalylglycine<br />
 +
**[[6hkp]] - hFIH1α + ASPP2 peptide + oxalylglycine<br />
 +
**[[6ruj]] - hFIH1α + ankyrin repeat + oxalylglycine<br />
-
[[2a24]], [[3f1n]], [[3f1o]], [[3f1p]], [[3h7w]] - hFIH 2α PAS domain + hFIH 1β PAS domain<br />
+
*FIH2α
-
[[3h82]] - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
+
-
===FIH1β===
+
**[[2a24]], [[3f1n]], [[3f1o]], [[3f1p]], [[3h7w]] - hFIH 2α PAS domain + hFIH 1β PAS domain<br />
 +
**[[3h82]] - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
-
[[2b02]], [[1x0o]] - hFIH 1β PAS domain<br />
+
*FIH1β
-
[[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR
+
 
 +
**[[2b02]], [[1x0o]] - hFIH 1β PAS domain<br />
 +
**[[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR<br />
 +
}}
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Dimeric factor inhibiting HIF complex with oxogluterate derivative (PDB code 1mzf)

Drag the structure with the mouse to rotate

3D Structures of factor inhibiting HIF

Updated on 05-June-2025

References

  1. ↑ Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbaurl H, Metzen E. Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40. doi: 10.1242/jcs.117564. Epub 2013, Apr 19. PMID:23606740 doi:http://dx.doi.org/10.1242/jcs.117564
  2. ↑ Dann CE 3rd, Bruick RK, Deisenhofer J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15351-6. Epub 2002 Nov 13. PMID:12432100 doi:http://dx.doi.org/10.1073/pnas.202614999

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Factor_inhibiting_HIF"
Personal tools