Factor inhibiting HIF
From Proteopedia
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| - | + | <StructureSection load='1mzf' size='350' side='right' scene='48/480806/Cv/1' caption='Dimeric factor inhibiting HIF complex with oxogluterate derivative (PDB code [[1mzf]]) '> | |
| - | For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen. | ||
| + | For details on '''Factor inhibiting HIF''' or '''Hypoxia-inducible factor 1-alpha inhibitor''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/5'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>. | ||
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| + | <scene name='48/480806/Cv/6'>Fe/2-oxogluterate binding site</scene> (PDB code [[1mzf]]).<ref>PMID:12432100</ref> | ||
| + | </StructureSection> | ||
== 3D Structures of factor inhibiting HIF == | == 3D Structures of factor inhibiting HIF == | ||
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*FIH1α complex with small molecule | *FIH1α complex with small molecule | ||
| - | **[[1yci]], [[3od4]], [[2yc0]], [[2yde] – hFIH1α + inhibitor<br /> | + | **[[1yci]], [[3od4]], [[2yc0]], [[2yde]], [[5op6]], [[5op8]], [[5opc]], [[8ihz]], [[8ii0]], [[8k71]], [[8k72]], [[8k73]], [[9i4h]] – hFIH1α + inhibitor<br /> |
**[[2w0x]] - hFIH1α + pyridine derivative<br /> | **[[2w0x]] - hFIH1α + pyridine derivative<br /> | ||
**[[2cgn]] – hFIH1α + succinate<br /> | **[[2cgn]] – hFIH1α + succinate<br /> | ||
**[[2cgo]] – hFIH1α + fumarate<br /> | **[[2cgo]] – hFIH1α + fumarate<br /> | ||
| - | **[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br /> | + | **[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]], [[4z2w]], [[5jwk]], [[7a1j]], [[7a1k]], [[7a1l]], [[7a1m]] – hFIH1α + oxoglutarate derivative<br /> |
| - | **[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br /> | + | **[[5jwk]], [[5jwl]] - hFIH1α (mutant) + ketoglutarate<br /> |
| + | **[[3kcx]], [[3kcy]], [[3od4]], [[4bio]], [[9jtx]] - hFIH1α + quinol derivative<br /> | ||
**[[4ai8]] - hFIH1α + daminozide<br /> | **[[4ai8]] - hFIH1α + daminozide<br /> | ||
| + | **[[4z1v]] - hFIH1α + oxalylglycine + NO<br /> | ||
| + | **[[9fsn]], [[9iif]] - hFIH1α + anemia drug<br /> | ||
*FIH1α complex with polypeptide | *FIH1α complex with polypeptide | ||
**[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br /> | **[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br /> | ||
| - | **[[2ilm]], [[3d8c]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br /> | + | **[[2ilm]], [[3d8c]], [[5jwp]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br /> |
**[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br /> | **[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br /> | ||
**[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br /> | **[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br /> | ||
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**[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br /> | **[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br /> | ||
**[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br /> | **[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br /> | ||
| - | **[[4b7e]], [[4b7k]], [[4jaa]] - hFIH1α + consensus ankyrin repeat peptide<br /> | + | **[[4b7e]], [[4b7k]], [[4jaa]], [[4nr1]], [[7a1q]] - hFIH1α + consensus ankyrin repeat peptide<br /> |
| + | **[[7a1n]], [[7a1o]], [[7a1p]], [[7a1s]] - hFIH1α + consensus ankyrin repeat peptide + oxoglutarate derivative <br /> | ||
| + | **[[6h9j]], [[6ha6]] - hFIH1α + TRPV3 peptide + oxalylglycine<br /> | ||
| + | **[[6hc8]] - hFIH1α + TRPA1 peptide + oxalylglycine<br /> | ||
| + | **[[6hl6]] - hFIH1α + ASPP peptide + oxalylglycine<br /> | ||
| + | **[[6hl5]] - hFIH1α + ASPP1 peptide + oxalylglycine<br /> | ||
| + | **[[6hkp]] - hFIH1α + ASPP2 peptide + oxalylglycine<br /> | ||
| + | **[[6ruj]] - hFIH1α + ankyrin repeat + oxalylglycine<br /> | ||
*FIH2α | *FIH2α | ||
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**[[2b02]], [[1x0o]] - hFIH 1β PAS domain<br /> | **[[2b02]], [[1x0o]] - hFIH 1β PAS domain<br /> | ||
| - | **[[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR | + | **[[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR<br /> |
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
| + | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of factor inhibiting HIF
Updated on 05-June-2025
References
- ↑ Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbaurl H, Metzen E. Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40. doi: 10.1242/jcs.117564. Epub 2013, Apr 19. PMID:23606740 doi:http://dx.doi.org/10.1242/jcs.117564
- ↑ Dann CE 3rd, Bruick RK, Deisenhofer J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15351-6. Epub 2002 Nov 13. PMID:12432100 doi:http://dx.doi.org/10.1073/pnas.202614999
