1rgx

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(New page: 200px<br /><applet load="1rgx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rgx, resolution 1.787&Aring;" /> '''Crystal Structure o...)
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[[Image:1rgx.gif|left|200px]]<br /><applet load="1rgx" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1rgx, resolution 1.787&Aring;" />
 
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'''Crystal Structure of resisitin'''<br />
 
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==Overview==
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==Crystal Structure of resisitin==
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Resistin, founding member of the resistin-like molecule (RELM) hormone, family, is secreted selectively from adipocytes and induces liver-specific, antagonism of insulin action, thus providing a potential molecular link, between obesity and diabetes. Crystal structures of resistin and RELMbeta, reveal an unusual multimeric structure. Each protomer comprises a, carboxy-terminal disulfide-rich beta-sandwich "head" domain and an, amino-terminal alpha-helical "tail" segment. The alpha-helical segments, associate to form three-stranded coiled coils, and surface-exposed, interchain disulfide linkages mediate the formation of tail-to-tail, hexamers. Analysis of serum samples shows that resistin circulates in two, distinct assembly states, likely corresponding to hexamers and trimers., Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in, pancreatic-insulin clamp studies reveals substantially more potent effects, on hepatic insulin sensitivity than those observed with wild-type, resistin. This result suggests that processing of the intertrimer, disulfide bonds may reflect an obligatory step toward activation.
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<StructureSection load='1rgx' size='340' side='right'caption='[[1rgx]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rgx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RGX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.787&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rgx OCA], [https://pdbe.org/1rgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rgx RCSB], [https://www.ebi.ac.uk/pdbsum/1rgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rgx ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1rgx TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RETN_MOUSE RETN_MOUSE] Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.<ref>PMID:11201732</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rg/1rgx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rgx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. Crystal structures of resistin and RELMbeta reveal an unusual multimeric structure. Each protomer comprises a carboxy-terminal disulfide-rich beta-sandwich "head" domain and an amino-terminal alpha-helical "tail" segment. The alpha-helical segments associate to form three-stranded coiled coils, and surface-exposed interchain disulfide linkages mediate the formation of tail-to-tail hexamers. Analysis of serum samples shows that resistin circulates in two distinct assembly states, likely corresponding to hexamers and trimers. Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin. This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation.
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==About this Structure==
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Disulfide-dependent multimeric assembly of resistin family hormones.,Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L Science. 2004 May 21;304(5674):1154-8. PMID:15155948<ref>PMID:15155948</ref>
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1RGX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RGX OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15155948 15155948]
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</div>
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<div class="pdbe-citations 1rgx" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Burley SK]]
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[[Category: Burley, S.K.]]
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[[Category: Patel SD]]
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[[Category: NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.]]
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[[Category: Rajala MW]]
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[[Category: Patel, S.D.]]
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[[Category: Scherer PE]]
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[[Category: Rajala, M.W.]]
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[[Category: Shapiro L]]
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[[Category: Scherer, P.E.]]
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[[Category: Shapiro, L.]]
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[[Category: hormone; glucose uptake; resistin/fizz family]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:35:18 2007''
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Current revision

Crystal Structure of resisitin

PDB ID 1rgx

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