Farnesyl diphosphate synthase 3D structures

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**[[1fps]]– cFPS – chicken<br />
**[[1fps]]– cFPS – chicken<br />
**[[1ubv]] – cFPS (mutant) <br />
**[[1ubv]] – cFPS (mutant) <br />
 +
**[[8wd5]] – FPS – silkworm<br />
 +
**[[5hxn]] – z,z-FPS – tomato<br />
 +
**[[5hxo]] – z,z-FPS (mutant)<br />
**[[1rtr]]– FPS – ''Staphylococcus aureus''<br />
**[[1rtr]]– FPS – ''Staphylococcus aureus''<br />
-
**[[1yhk]] – TcFPS – ''Trypanosoma cruzi''<br />
+
**[[1yhk]], [[5qqc]], [[6r04]], [[3iba]], [[3icz]], [[3icm]], [[3icn]], [[1yhl]], [[6se2]], [[6sfa]] – TcFPPS – ''Trypanosoma cruzi''<br />
 +
**[[6vjc]], [[6w71]], [[4k10]], [[4jzb]], [[4jzx]]– LmFPPS – ''Leishmania major''<br />
**[[3lvs]], [[3m0g]] – FPS – ''Rhodobacter capsulatus''<br />
**[[3lvs]], [[3m0g]] – FPS – ''Rhodobacter capsulatus''<br />
**[[3m9u]] – LbFPS – ''Lactobacillus brevis''<br />
**[[3m9u]] – LbFPS – ''Lactobacillus brevis''<br />
**[[5ayp]] – FPS – ''Geobacillus stearothermophilus''<br />
**[[5ayp]] – FPS – ''Geobacillus stearothermophilus''<br />
-
**[[5hxn]] – z,z-FPS – tomato<br />
+
**[[6ww1]] – LmFPS (mutant) – ''Leishmania major''<br />
-
**[[5hxo]] – z,z-FPS (mutant)<br />
+
**[[4ryp]] – TbFPS –''Trypanosoma brucei''<br />
-
**[[4jzb]] – Leshmaniasis major FPS in complex<br />
+
**[[3ts7]] – FPS – ''Methylococcus capsulatus''<br />
 +
**[[8f8f]] – MtFPS – ''Mycobacterium tuberculosis''<br />
*FPS binary complexes
*FPS binary complexes
-
**[[1yq7]], [[1yv5]], [[2f89]], [[2f8c]], [[2f92]], [[2f94]], [[2f9k]], [[2rah]], [[2opn]], [[2vf6]], [[3b7l]], [[2opm]], [[3n1v]], [[3n1w]], [[3n3l]], [[3n45]], [[3n46]], [[3n49]], [[3n5j]], [[3n6k]], [[3n5h]], [[4dem]], [[4ga3]], [[4jvj]], [[4pvx]], [[4pvy]], [[4rxa]], [[5dgn]], [[5diq]], [[5djp]], [[5djr]], [[5djv]], [[5juz]], [[5jv0]], [[5jv1]], [[5jv2]], [[5ksx]], [[5ygi]] - hFPS + inhibitor<br />
+
**[[1yq7]], [[1yv5]], [[2f89]], [[2f8c]], [[2f92]], [[2f94]], [[2f9k]], [[2rah]], [[2opn]], [[2vf6]], [[3b7l]], [[2opm]], [[3n1v]], [[3n1w]], [[3n3l]], [[3n45]], [[3n46]], [[3n49]], [[3n5j]], [[3n6k]], [[3n5h]], [[4dem]], [[4ga3]], [[4jvj]], [[4pvx]], [[4pvy]], [[4rxa]], [[5dgn]], [[5diq]], [[5djp]], [[5djr]], [[5djv]], [[5juz]], [[5jv0]], [[5jv1]], [[5jv2]], [[5ksx]], [[5ygi]], [[6n7y]], [[6n7z]], [[6n82]], [[6n83]], [[6oag]], [[6oah]] - hFPS + inhibitor<br />
**[[2qis]], [[3cp6]], [[3rye]], [[3s4j]], [[4n9u]] - hFPS (mutant) + inhibitor<br />
**[[2qis]], [[3cp6]], [[3rye]], [[3s4j]], [[4n9u]] - hFPS (mutant) + inhibitor<br />
**[[4kfa]], [[4kpj]], [[4kq5]] - hFPS (mutant) + osteoporosis drug<br />
**[[4kfa]], [[4kpj]], [[4kq5]] - hFPS (mutant) + osteoporosis drug<br />
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**[[1ubw]], [[1ubx]] - cFPS (mutant) + GDP<br />
**[[1ubw]], [[1ubx]] - cFPS (mutant) + GDP<br />
**[[1uby]] - cFPS (mutant) + dimethylallyl PP<br />
**[[1uby]] - cFPS (mutant) + dimethylallyl PP<br />
-
**[[2i19]], [[2ewg]], [[2ogd]], [[2p1c]], [[3dyg]], [[3dyh]], [[3efq]], [[3egt]] - TbFPS + inhibitor – ''Trypanosoma brucei''<br />
+
**[[6b07]], [[6b02]], [[6b04]], [[6b06]] – FPS + inhibitor – spruce budworm moth<br />
-
**[[2for]]– FPS + IPP – ''Shigella flexneri''<br />
+
-
**[[3id0]]– TcFPS + inhibitor<br />
+
-
**[[3pde]] – LbFPS + IPP<br />
+
**[[5hxp]] – z,z-FPS (mutant) + IPP<br />
**[[5hxp]] – z,z-FPS (mutant) + IPP<br />
**[[5hxq]] – z,z-FPS (mutant) + DMSPP<br />
**[[5hxq]] – z,z-FPS (mutant) + DMSPP<br />
-
**[[6b07]], [[6b02]], [[6b04]], [[6b06]] – FPS + inhibitor – spruce budworm moth<br />
+
**[[2i19]], [[2ewg]], [[2ogd]], [[2p1c]], [[3dyg]], [[3dyh]], [[3efq]], [[3egt]], [[4rxe]], [[5ael]], [[5afx]] - TbFPS + inhibitor <br />
 +
**[[4rxd]] – TbFBS + risedronate <br />
 +
**[[2for]]– FPS + IPP – ''Shigella flexneri''<br />
 +
**[[4jzb]], [[4jzx]], [[4k10]] – Leshmaniasis major FPS + inhibitor<br />
 +
**[[3id0]], [[3iba]], [[3ick]], [[3icm]], [[3icn]], [[3icz]], [[4rxc]], [[5ahu]], [[5qpd]], [[6sdn]], [[6sdo]], [[6sdp]], [[6sdq]], [[6sf8]], [[6sf9]], [[6shv]], [[6si5]] – TcFPS + inhibitor<br />
 +
**[[6t7n]] – TcFPS + IPP<br />
 +
**[[5qpe]], [[5qpk]], [[5qpo]], [[5qq3]], [[5qq8]] – TcFPS + imidazole inhibitor<br />
 +
**[[5qpg]], [[5qpn]], [[6r08]] – TcFPS + indole inhibitor<br />
 +
**[[5qpf]], [[5qq1]], [[6r09]], [[6r0a]], [[6r0b]] – TcFPS + piperazine inhibitor<br />
 +
**[[6r06]] – TcFPS + piperidine inhibitor<br />
 +
**[[5qph]], [[5qq0]] – TcFPS + morpholine inhibitor<br />
 +
**[[5qpi]], [[5qpw]], [[5qpy]], [[5qq5]], [[5qqa]] – TcFPS + pyrazole inhibitor<br />
 +
**[[5qps]] – TcFPS + oxazole inhibitor<br />
 +
**[[5qpj]], [[5qpu]], [[5qq9]] – TcFPS + acetamide inhibitor<br />
 +
**[[5qpq]] – TcFPS + ethanamide inhibitor<br />
 +
**[[5qpv]] – TcFPS + caboxamide inhibitor<br />
 +
**[[5qpl]], [[5qpm]], [[5qpp]], [[5qpr]], [[5qpz]], [[5qq4]] – TcFPS + urea inhibitor<br />
 +
**[[5qpt]] – TcFPS + thiazine inhibitor<br />
 +
**[[5qq2]], [[6r07]] – TcFPS + thiophene inhibitor<br />
 +
**[[5qpx]] – TcFPS + quinoline inhibitor<br />
 +
**[[5qq6]], [[5qq7]] – TcFPS + pyrrolidine inhibitor<br />
 +
**[[6r05]] – TcFPS + pyridine inhibitor<br />
 +
**[[5qqb]] – TcFPS + benzodiazo inhibitor<br />
 +
**[[3pde]] – LbFPS + IPP<br />
 +
**[[8f8k]] – MtFPS + IPP<br />
 +
**[[8f8l]] – MtFPS + DMAP<br />
 +
**[[6vjc]] – LmFPS (mutant) + inhibitor<br />
 +
**[[4llt]] - RdFPS + IPP – ''Roseobacter denitrificans''<br />
 +
**[[7my6]] - FPS + IPP – ''Synechococcus elongatus<''br />
*FPS ternary complexes
*FPS ternary complexes
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**[[5cg6]] - hFPS + IPP + bisphosphonate<br />
**[[5cg6]] - hFPS + IPP + bisphosphonate<br />
**[[4l2x]] - hFPS + PP + inhibitor<br />
**[[4l2x]] - hFPS + PP + inhibitor<br />
 +
**[[5hxt]] – z,z-FPS (mutant) + DMSPP + IPP<br />
**[[1rqi]] – EcFPS + IPP + dimethylallyl S-thioloPP – ''Escherichia coli''<br />
**[[1rqi]] – EcFPS + IPP + dimethylallyl S-thioloPP – ''Escherichia coli''<br />
**[[1rqj]] - EcFPS + IPP + inhibitor<br />
**[[1rqj]] - EcFPS + IPP + inhibitor<br />
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**[[3ez3]] - PvFPS + IPP + inhibitor – ''Plasmodium vivax''<br />
**[[3ez3]] - PvFPS + IPP + inhibitor – ''Plasmodium vivax''<br />
**[[3dyf]] - TbFPS + IPP + inhibitor<br />
**[[3dyf]] - TbFPS + IPP + inhibitor<br />
-
**[[5hxt]] – z,z-FPS (mutant) + DMSPP + IPP<br />
+
**[[4lls]] - RdFPS + IPP + geranyl derivative <br />
 +
 
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of farnesyl diphosphate synthase

Updated on 08-June-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Hannah Campbell, Sandra B. Gabelli

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