Fatty acid synthase 3D structures

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(New page: == 3D structures of fatty acid synthase== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Fatty acid synthase **[...)
Current revision (08:08, 9 June 2025) (edit) (undo)
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Fatty acid synthase
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*Fatty acid synthase; Domains – KS-MAT 2-963; MAT 422-823; dehydratase 858-1102; core modifying 855-2511;enoyl-ACP-reductase 1529-1867; ACP 2114-2202; thioesterase 2221-2502
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**[[1xkt]], [[4z49]] – hFAS thioesterase domain – human<br />
+
**[[9b7z]], [[9b80]] – hFAS 1-854 – human – Cryo EM<br />
 +
**[[8eyi]], [[8eyk]] – hFAS 854-2511 – Cryo EM<br />
 +
**[[1xkt]], [[4z49]] – hFAS thioesterase domain <br />
 +
**[[8g7x]], [[8zev]] – hFAS dehydratase domain
**[[2jfd]] – hFAS MAT domain<br />
**[[2jfd]] – hFAS MAT domain<br />
**[[3hhd]] - hFAS KS-MAT domain<br />
**[[3hhd]] - hFAS KS-MAT domain<br />
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**[[2cf2]], [[2vz8]] – pFAS – pig<br />
**[[2cf2]], [[2vz8]] – pFAS – pig<br />
**[[2png]] – FAS ACP domain – rat<br />
**[[2png]] – FAS ACP domain – rat<br />
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**[[5my2]] – FAS DI domain – mouse<br />
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**[[5my2]] – FAS KS-MAT DI domain – mouse<br />
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**[[2uv8]], [[3hmj]] – yFAS α+β subunits - yeast<br />
+
-
**[[2pff]], [[2was]], [[2ml8]] – yFAS α subunit<br />
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**[[6fn6]] – FAS – ''Drosophila melanogaster''<br />
**[[6fn6]] – FAS – ''Drosophila melanogaster''<br />
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**[[1t8k]] – EcFAS ACP domain - ''Escherichia coli''<br />
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**[[2uv8]], [[3hmj]], [[6ql9]] – yFAS α+β subunits + FMN - yeast<br />
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**[[2k92]], [[2k93]], [[2k94]] - EcFAS ACP domain – NMR<br />
+
**[[6jsh]], [[6jsi]], [[6ql5]], [[6ql6]], [[6ta1]], [[6u5t]], [[6u5u]], [[6wc7]], [[8prw]], [[8psm]] - yFAS α+β subunits + FMN – Cryo EM<br />
 +
**[[2pff]], [[2was]], [[2ml8]] – yFAS α subunit<br />
**[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br />
**[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br />
-
**[[4v8w]] – MtFAS I – Cryo-EM<br />
+
**[[4v8w]], [[6gjc]] – MtFAS I – Cryo-EM<br />
**[[4v8l]] – FAS – ''Mycobacterium smegmatis'' – Cryo-EM<br />
**[[4v8l]] – FAS – ''Mycobacterium smegmatis'' – Cryo-EM<br />
**[[4v58]] – TlFAS – ''Thermomyces lanuginosus''<br />
**[[4v58]] – TlFAS – ''Thermomyces lanuginosus''<br />
 +
**[[6u5v]], [[6u5w]], [[7tui]] - CaFAS α+β subunits + FMN – ''Candida albicans'' - Cryo EM<br />
 +
**[[7bc4]] - PpFAS α+β subunits – ''Pischia pastoris'' - Cryo EM<br />
 +
**[[7bc5]] - PpFAS α subunit ACP domain - Cryo EM<br />
 +
**[[7q5s]] - FAS – ''Chaetonium thermophilum'' - Cryo EM<br />
*FAS complex with fatty acid
*FAS complex with fatty acid
 +
**[[9mj9]] – hFAS 1-854 + Ser-ACP – Cryo EM
**[[3tjm]] – hFAS thioesterase domain + fatty acid<br />
**[[3tjm]] – hFAS thioesterase domain + fatty acid<br />
-
**[[2fae]] – EcFAS ACP domain + decanethioate<br />
+
**[[8pcg]], [[8prv]], [[8ps1]], [[8ps2]], [[8ps8]], [[8ps9]], [[8psa]], [[8psf]], [[8psj]], [[8psk]], [[8psl]], [[8psp]] - yFAS thioesterase domain + ACP – Cryo EM
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**[[2fad]] – EcFAS ACP domain + heptanthioate<br />
+
**[[1kpg]] – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine<br />
**[[1kpg]] – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine<br />
**[[1kph]] – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br />
**[[1kph]] – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br />
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*FAS complex with reactants
*FAS complex with reactants
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**[[2jfk]] – hFAS + malonyl CoA<br />
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**[[8vle]], [[8vlp]], [[8vm0]], [[8vm5]], [[8vm6]], [[8vm7]], [[8vmc]], [[8vmd]] - hFAS + NADP – Cryo EM
 +
**[[8vf7]], [[8vg4]] - hFAS + NADP + Ser-ACP – Cryo EM
 +
**[[2jfk]] – hFAS MAT domain + malonyl CoA<br />
**[[2vz9]] – pFAS + NADP<BR />
**[[2vz9]] – pFAS + NADP<BR />
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**[[5my0]] - mFAS + malonyl CoA<br />
+
**[[5my0]] - mFAS KS-MAT domain + malonyl CoA<br />
 +
**[[6rop]] - mFAS KS-MAT domain + octanoyl CoA<br />
**[[2wat]] – yFAS α subunit + CoA<br />
**[[2wat]] – yFAS α subunit + CoA<br />
**[[4v59]] – TlFAS + NADP<BR />
**[[4v59]] – TlFAS + NADP<BR />
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**[[2cg5]] - hFAS ACP domain + AASD-PPT<br />
**[[2cg5]] - hFAS ACP domain + AASD-PPT<br />
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**[[2fhs]] – EcFAS ACP domain + enoyl-ACP reductase <br />
+
**[[6ql7]] – yFAS α+β subunits + translation machinery-associated protein 17<br />
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**[[3ejb]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme<br />
+
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**[[3ejb]], [[3eje]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid<br />
+
*FAS complex with inhibitor
*FAS complex with inhibitor
 +
**[[7mhd]], [[7mhe]] – hFAS thioesterase domain + inhibitor<br />
**[[2px6]] – hFAS thioesterase domain + orlistat<br />
**[[2px6]] – hFAS thioesterase domain + orlistat<br />
**[[4piv]], [[5c37]], [[6nna]] – hFAS (mutant) + NADP + inhibitor<br />
**[[4piv]], [[5c37]], [[6nna]] – hFAS (mutant) + NADP + inhibitor<br />
**[[2vkz]] - yFAS α+β subunits + cerulenin<br />
**[[2vkz]] - yFAS α+β subunits + cerulenin<br />
 +
**[[8gkc]] – hFAS core modifying domain + drug – Cryo EM<br />
 +
 +
For FAS acyl carrier protein see [[Acyl carrier protein]]
}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of fatty acid synthase

Updated on 09-June-2025

For FAS acyl carrier protein see Acyl carrier protein

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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