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1w2k

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[[Image:1w2k.gif|left|200px]]
[[Image:1w2k.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1w2k |SIZE=350|CAPTION= <scene name='initialview01'>1w2k</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1w2k", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Bgc+Binding+Site+For+Chain+L'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=380:(2R)-2-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO)-N-BENZYL-2-(3,4-DIMETHOXYPHENYL)ACETAMIDE'>380</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1w2k| PDB=1w2k | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2k OCA], [http://www.ebi.ac.uk/pdbsum/1w2k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w2k RCSB]</span>
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}}
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'''TF7A_4380 COMPLEX'''
'''TF7A_4380 COMPLEX'''
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[[Category: Wallbaum, S.]]
[[Category: Wallbaum, S.]]
[[Category: Weber, L.]]
[[Category: Weber, L.]]
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[[Category: blood coagulation]]
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[[Category: Blood coagulation]]
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[[Category: calcium-binding]]
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[[Category: Calcium-binding]]
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[[Category: co-factor]]
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[[Category: Co-factor]]
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[[Category: coagulation]]
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[[Category: Coagulation]]
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[[Category: enzyme complex]]
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[[Category: Enzyme complex]]
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[[Category: gamma-carboxyglutamic acid]]
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[[Category: Gamma-carboxyglutamic acid]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: plasma]]
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[[Category: Plasma]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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[[Category: vitamin k]]
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[[Category: Vitamin k]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:03:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:30:16 2008''
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Revision as of 10:03, 3 May 2008

Image:1w2k.gif

Template:STRUCTURE 1w2k

TF7A_4380 COMPLEX


Overview

Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.

About this Structure

1W2K is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864 Page seeded by OCA on Sat May 3 13:03:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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