1w3s
From Proteopedia
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'''THE CRYSTAL STRUCTURE OF RECO FROM DEINOCOCCUS RADIODURANS.''' | '''THE CRYSTAL STRUCTURE OF RECO FROM DEINOCOCCUS RADIODURANS.''' | ||
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[[Category: Mcsweeney, S M.]] | [[Category: Mcsweeney, S M.]] | ||
[[Category: Timmins, J.]] | [[Category: Timmins, J.]] | ||
| - | [[Category: | + | [[Category: Cys4 zinc finger]] |
| - | [[Category: | + | [[Category: Dna repair]] |
| - | [[Category: | + | [[Category: Ob-fold]] |
| - | [[Category: | + | [[Category: Reco]] |
| - | [[Category: | + | [[Category: Sad]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:07:10 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:07, 3 May 2008
THE CRYSTAL STRUCTURE OF RECO FROM DEINOCOCCUS RADIODURANS.
Overview
The RecFOR pathway has been shown to be essential for DNA repair through the process of homologous recombination in bacteria and, recently, to be important in the recovery of stalled replication forks following UV irradiation. RecO, along with RecR, RecF, RecQ and RecJ, is a principal actor in this fundamental DNA repair pathway. Here we present the three-dimensional structure of a member of the RecO family. The crystal structure of Deinococcus radiodurans RecO (drRecO) reveals possible binding sites for DNA and for the RecO-binding proteins within its three discrete structural regions: an N-terminal oligonucleotide/oligosaccharide-binding domain, a helical bundle and a zinc-finger motif. Furthermore, drRecO was found to form a stable complex with RecR and to bind both single- and double-stranded DNA. Mutational analysis confirmed the existence of multiple DNA-binding sites within the protein.
About this Structure
1W3S is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.
Reference
Crystal structure and DNA-binding analysis of RecO from Deinococcus radiodurans., Leiros I, Timmins J, Hall DR, McSweeney S, EMBO J. 2005 Mar 9;24(5):906-18. Epub 2005 Feb 17. PMID:15719017 Page seeded by OCA on Sat May 3 13:07:10 2008
