Flavin reductase

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<StructureSection load='' size='350' side='right' scene='49/490853/Cv/1' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '>
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<StructureSection load='1he2' size='350' side='right' scene='' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '>
 
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== Function ==
== Function ==
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FR catalytic reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia. Bacterial FR are used to sensitize tumors to drugs.
FR catalytic reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia. Bacterial FR are used to sensitize tumors to drugs.
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== Structural insights ==
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The <scene name='49/490853/Cv/4'>NADP containing active site can accommodate a variety of ligands</scene> because the binding is achieved mainly via hydrophobic interactions ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}).<ref>PMID:11224564</ref>
</StructureSection>
</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*NADPH-dependent Flavin reductase or biliverdin IX beta reductase
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**[[8ell]], [[8elm]] – hFR – human
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**[[1hdo]], [[7er6]], [[9c18]] - hFR + NADP <br />
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**[[6opl]] – hFR (mutant) + NADP <br />
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**[[1he2]] - hFR + biliverdin IX α + NADP<BR />
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**[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
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**[[1he4]] - hFR + FMN + NADP<BR />
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**[[1he5]] - hFR + lumichrome + NADP<BR />
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**[[5ooh]] – hFR + NADP + erythrosine<br />
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**[[5oog]] – hFR + NADP + phloxine + cyanosine<br />
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**[[7er7]], [[7er8]], [[7er9]], [[7era]], [[7erb]], [[7erc]], [[7erd]], [[7ere]] – hFR + NADP + drug<br />
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**[[8k4k]], [[9c16]], [[9c17]] – hFR + NADP + inhibitor<br />
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**[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''<br />
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**[[5cho]] - FR + FAD – uncultured bacteria<br />
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**[[1qfj]] – FR – ''Escherichia coli''<br />
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**[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
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**[[2bkj]] - VhFR + NAD + FMN<br />
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*NADH-dependent Flavin reductase
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[[1qfj]] – FR – ''Escherichia coli''<br />
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**[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
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[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
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**[[1rz1]] - GtFR + FAD + NAD<br />
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[[2bkj]] - VhFR + NAD + FMN<br />
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**[[5n6q]] - PpFR + FMN – ''Pseudomonas putida''<br />
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[[1hdo]] - hFR + NADP - human<br />
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**[[4uth]] - PpFR (mutant) + FMN <br />
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[[1he2]] - hFR + biliverdin IX α + NADP<BR />
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**[[5lnj]], [[5lni]], [[4uti]], [[4utj]] - PpFR (mutant) + FMN derivative + coumarin derivative<br />
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[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
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**[[2d36]] - StFR + FMN – ''Sulfurisphaera tokodaii''<br />
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[[1he4]] - hFR + FMN + NADP<BR />
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**[[2d37]] - StFR + FMN + NAD<br />
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[[1he5]] - hFR + lumichrome + NADP<BR />
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**[[2d38]] - StFR + FMN + NADP<br />
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[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
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**[[9fd4]], [[9fd5]] - FR + FAD – ''Streptomyces albogriseolus''<br />
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[[1rz1]] - GtFR + FAD + NAD<br />
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**[[8ct0]] - FR + FAD + NAD – ''Kitasatospora aureofaciens''<br />
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[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''
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}}
== References ==
== References ==
<references/>
<references/>

Current revision

Human flavin reductase complex with biliverdin IX α and NADP (PDB code 1he2)

Drag the structure with the mouse to rotate

3D structures of flavin reductase

Updated on 06-July-2025

References

  1. ↑ Yubisui T, Takeshita M, Yoneyama Y. Reduction of methemoglobin through flavin at the physiological concentration by NADPH-flavin reductase of human erythrocytes. J Biochem. 1980 Jun;87(6):1715-20. PMID:7400118
  2. ↑ Pereira PJ, Macedo-Ribeiro S, Parraga A, Perez-Luque R, Cunningham O, Darcy K, Mantle TJ, Coll M. Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme. Nat Struct Biol. 2001 Mar;8(3):215-20. PMID:11224564 doi:10.1038/84948

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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