Flavin reductase

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<StructureSection load='1he2' size='450' side='right' scene='49/490853/Cv/1' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '>
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<StructureSection load='' size='350' side='right' scene='49/490853/Cv/1' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '>
== Function ==
== Function ==
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== Structural insights ==
== Structural insights ==
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The <scene name='49/490853/Cv/3'>NADP containing active site can accommodate a variety of ligands</scene> because the binding is achieved mainly via hydrophobic interactions ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}).<ref>PMID:11224564</ref>
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The <scene name='49/490853/Cv/4'>NADP containing active site can accommodate a variety of ligands</scene> because the binding is achieved mainly via hydrophobic interactions ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}).<ref>PMID:11224564</ref>
</StructureSection>
</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1qfj]] – FR – ''Escherichia coli''<br />
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*NADPH-dependent Flavin reductase or biliverdin IX beta reductase
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[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
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[[2bkj]] - VhFR + NAD + FMN<br />
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[[1hdo]] - hFR + NADP - human<br />
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[[1he2]] - hFR + biliverdin IX α + NADP<BR />
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[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
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[[1he4]] - hFR + FMN + NADP<BR />
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[[1he5]] - hFR + lumichrome + NADP<BR />
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[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
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[[1rz1]] - GtFR + FAD + NAD<br />
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[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''
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**[[8ell]], [[8elm]] – hFR – human
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**[[1hdo]], [[7er6]], [[9c18]] - hFR + NADP <br />
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**[[6opl]] – hFR (mutant) + NADP <br />
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**[[1he2]] - hFR + biliverdin IX α + NADP<BR />
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**[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
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**[[1he4]] - hFR + FMN + NADP<BR />
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**[[1he5]] - hFR + lumichrome + NADP<BR />
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**[[5ooh]] – hFR + NADP + erythrosine<br />
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**[[5oog]] – hFR + NADP + phloxine + cyanosine<br />
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**[[7er7]], [[7er8]], [[7er9]], [[7era]], [[7erb]], [[7erc]], [[7erd]], [[7ere]] – hFR + NADP + drug<br />
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**[[8k4k]], [[9c16]], [[9c17]] – hFR + NADP + inhibitor<br />
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**[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''<br />
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**[[5cho]] - FR + FAD – uncultured bacteria<br />
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**[[1qfj]] – FR – ''Escherichia coli''<br />
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**[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
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**[[2bkj]] - VhFR + NAD + FMN<br />
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*NADH-dependent Flavin reductase
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**[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
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**[[1rz1]] - GtFR + FAD + NAD<br />
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**[[5n6q]] - PpFR + FMN – ''Pseudomonas putida''<br />
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**[[4uth]] - PpFR (mutant) + FMN <br />
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**[[5lnj]], [[5lni]], [[4uti]], [[4utj]] - PpFR (mutant) + FMN derivative + coumarin derivative<br />
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**[[2d36]] - StFR + FMN – ''Sulfurisphaera tokodaii''<br />
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**[[2d37]] - StFR + FMN + NAD<br />
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**[[2d38]] - StFR + FMN + NADP<br />
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**[[9fd4]], [[9fd5]] - FR + FAD – ''Streptomyces albogriseolus''<br />
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**[[8ct0]] - FR + FAD + NAD – ''Kitasatospora aureofaciens''<br />
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}}
== References ==
== References ==
<references/>
<references/>

Current revision

Human flavin reductase complex with biliverdin IX α and NADP (PDB code 1he2)

Drag the structure with the mouse to rotate

3D structures of flavin reductase

Updated on 06-July-2025

References

  1. ↑ Yubisui T, Takeshita M, Yoneyama Y. Reduction of methemoglobin through flavin at the physiological concentration by NADPH-flavin reductase of human erythrocytes. J Biochem. 1980 Jun;87(6):1715-20. PMID:7400118
  2. ↑ Pereira PJ, Macedo-Ribeiro S, Parraga A, Perez-Luque R, Cunningham O, Darcy K, Mantle TJ, Coll M. Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme. Nat Struct Biol. 2001 Mar;8(3):215-20. PMID:11224564 doi:10.1038/84948

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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