Gal3-Gal80-Gal4
From Proteopedia
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| - | + | <StructureSection load='1d66' size='350' side='right' caption='Yeast Gal4 complex with DNA and Zn+2 ions (wheat) (PDB entry [[1d66]])' scene=''> | |
| + | == Function == | ||
| - | '''Gal3-Gal80-Gal4''' proteins of yeast comprise a signal transducer that controls the galactose-inducible Gal4-mediated transcription activation of GAL regulon genes. In the absence of galactose Gal80 binds to Gal4 and prohibits it from activating transcription. In the presence of galactose, Gal3 binds to Gal80 to prohibit its inhibition of Gal4. For '''Gal4''' details see [[User:Amir Mitchell/Gal4]]. | + | '''Gal3-Gal80-Gal4''' proteins of yeast comprise a signal transducer that controls the galactose-inducible Gal4-mediated transcription activation of GAL regulon genes. '''Gal3''' and '''Gal4'''<ref>PMID:16670683</ref> are regulators of the rapid induction of the galactose system. In the absence of galactose Gal80<ref>PMID:15695361</ref> binds to Gal4 and prohibits it from activating transcription. In the presence of galactose, Gal3 binds to Gal80 to prohibit its inhibition of Gal4. For '''Gal4''' details see <br />[[User:Amir Mitchell/Gal4]]<br/ >[[User: Wayne Decatur/Gal 4]]<br />[[Evans Gal4]]<br />[[DNA-protein interactions]]. |
The Gal4 protein consists of a <scene name='48/483908/Dimer/2'>dimer</scene> of identical subunits. | The Gal4 protein consists of a <scene name='48/483908/Dimer/2'>dimer</scene> of identical subunits. | ||
| - | + | </StructureSection> | |
== 3D Structures of Gal3-Gal80-Gal4 == | == 3D Structures of Gal3-Gal80-Gal4 == | ||
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**[[3coq]] - yGal4 DNA-binding and dimerization domains + DNA<br /> | **[[3coq]] - yGal4 DNA-binding and dimerization domains + DNA<br /> | ||
**[[1d66]] – yGal4 + DNA | **[[1d66]] – yGal4 + DNA | ||
| + | **[[7uik]], [[7uio]] – yGal4 in mediator-PIC complex – Cryo EM | ||
*Gal80 | *Gal80 | ||
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**[[3bts]] – yGal80 + Gal4 peptide + NAD <br /> | **[[3bts]] – yGal80 + Gal4 peptide + NAD <br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Gal3-Gal80-Gal4
Updated on 07-July-2025
References
- ↑ Traven A, Jelicic B, Sopta M. Yeast Gal4: a transcriptional paradigm revisited. EMBO Rep. 2006 May;7(5):496-9. PMID:16670683 doi:http://dx.doi.org/10.1038/sj.embor.7400679
- ↑ Pilauri V, Bewley M, Diep C, Hopper J. Gal80 dimerization and the yeast GAL gene switch. Genetics. 2005 Apr;169(4):1903-14. Epub 2005 Feb 3. PMID:15695361 doi:http://dx.doi.org/10.1534/genetics.104.036723
