Aricept Complexed with Acetylcholinesterase (Hebrew)
From Proteopedia
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| - | <StructureSection load='1eve' size='450' side='right' scene=' | + | <StructureSection load='1eve' size='450' side='right' scene='29/2908/1eve_e20_cartoon/1' caption=''> |
[[Image:E2020_interactins_in_AChE_gorge.jpg|left|250px]]<br /> | [[Image:E2020_interactins_in_AChE_gorge.jpg|left|250px]]<br /> | ||
<div dir='rtl' align='right'> | <div dir='rtl' align='right'> | ||
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==תוצאות== | ==תוצאות== | ||
</p> | </p> | ||
| - | <p dir='rtl'>מבנה תלת-ממדי של אריצפט בשילוב עם אצטיל כולין אסתראז מראה שלאריצפט יש <scene name='1eve/E2020_close_up_with_84_279/13'> | + | <p dir='rtl'>מבנה תלת-ממדי של אריצפט בשילוב עם אצטיל כולין אסתראז מראה שלאריצפט יש <scene name='1eve/E2020_close_up_with_84_279/13'> unique orientation</scene> לאורך נקיק של האתר הפעיל, הוא מתקדם מאתר אניוני (<scene name='1eve/E2020_close_up_with_84lbld/7'>W84</scene>) (למטה) עד להאתר אניוני שולי (<scene name='1eve/E2020_close_up_with_84_279lbld/5'>W279</scene>) (למעלה) דרך אינטראקציות עם חומצות אמיניות ארומאטיות שמורות. עם זאת, אריצפט לא יוצר מגעים ישרים עם שלישיית קטליטית או חור אוקסיאניוני, אלא <scene name='1eve/E20_interactionshown/8'>indirectly via solvent molecules</scene>. |
==מסקנות== | ==מסקנות== | ||
</p> | </p> | ||
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Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs., Kryger G, Silman I, Sussman JL, Structure. 1999 Mar 15;7(3):297-307. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10368299 10368299] | Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs., Kryger G, Silman I, Sussman JL, Structure. 1999 Mar 15;7(3):297-307. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10368299 10368299] | ||
| - | [[ar: | + | [[ar:Aricept_Complexed_with_Acetylcholinesterase (Arabic)]] |
| - | [[zh: | + | [[ca:Aricept_Complexed_with_Acetylcholinesterase (Catalan)]] |
| - | [[ | + | [[zh:Aricept_Complexed_with_Acetylcholinesterase (Chinese)]] |
| - | [[de: | + | [[cs:Aricept_Complexed_with_Acetylcholinesterase (Czech)]] |
| - | [[ | + | [[de:Aricept_Complexed_with_Acetylcholinesterase (German)]] |
| - | [[es: | + | [[en:Aricept_Complexed_with_Acetylcholinesterase]] |
| - | [[ | + | [[es:Aricept_Complexed_with_Acetylcholinesterase (Spanish)]] |
| - | [[ | + | [[fr:Aricept_Complexed_with_Acetylcholinesterase (French)]] |
| - | [[it: | + | [[he:Aricept_Complexed_with_Acetylcholinesterase (Hebrew)]] |
| + | [[it:Aricept_Complexed_with_Acetylcholinesterase (Italian)]] | ||
| + | [[ru:Aricept_Complexed_with_Acetylcholinesterase (Russian)]] | ||
| + | [[sk:Aricept_Complexed_with_Acetylcholinesterase (Slovak)]] | ||
| + | [[vi:Aricept_Complexed_with_Acetylcholinesterase (Vietnamese)]] | ||
| + | [[tr:Aricept_Complexed_with_Acetylcholinesterase (Turkish)]] | ||
Current revision
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About this Structure
1EVE is a 1 chain structure with sequence from Torpedo californica. The June 2004 RCSB PDB Molecule of the Month feature on Acetylcholinesterase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2004_6. Full crystallographic information is available from OCA.
