Glutathione peroxidase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:46, 17 July 2025) (edit) (undo)
 
(17 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_2f8a| PDB=2f8a | SIZE=400| SCENE= |right|CAPTION=Human glutatione peroxidase 1 complex with malonic acid, [[2f8a]] }}
+
<StructureSection load='3e0u' size='340' side='right' caption='Glutatione peroxidase 1 complex with glycerol and ammonium ion, [[3e0u]]' scene=''>
 +
== Function ==
 +
'''Glutathione peroxidase''' (GPX) reduces lipid hydroperoxides to alcohols and free hydrogen peroxide to water. Thus, GPX protects the organism from oxidative damage<ref>PMID:11215509</ref>. There are several isozymes of GPX. Eight isozymes have been found in human.<br />
 +
* '''GPX1''' is found in the cytoplasm and reduces hydrogen peroxide<ref>PMID:17465855</ref>.<br />
 +
* '''GPX2''' is intestinal and extracellular and is the major oxidative stress-inducible GPX in lungs.<br />
 +
* '''GPX3''' is abundant in plasma.<br />
 +
* '''GPX4''' substrate is lipid hydroxyperoxide<ref>PMID:17895430</ref>.<br />
 +
* '''GPX5''' protects spermatozoa from effects of lipid peroxidation<ref>PMID:9639555</ref>.<br />
 +
* '''GPX7''' is a strong neutralizer of H<sub>2</sub>O<sub>2</sub> independent of glutathione<ref>PMID:22157330</ref>.
 +
== Relevance ==
 +
Low levels of GPX are found in patients of vitiligo, type 2 diabetes and relapsing multiple sclerosis. There is age-related decrease of GPX activity and hence in antioxidant activity. '''GPX3''' is a candidate of inducing anticancer drug resistance in ovarian clear cell adenocarcinoma<ref>PMID:19020706</ref>. '''GPX4''' protects cortical neurons from oxidative injury<ref>PMID:16673405</ref>'''GPX7''' has potential tumor suppressor function<ref>PMID:23580780</ref>.
-
'''Glutathione peroxidase''' (GPX) reduces lipid hydroperoxides to alcohols and free hydrogen peroxide to water. Thus, GPX protects the organism from oxidative damage. There are several isozymes of GPX. Eight isozymes have been found in human. GPX1 is found in the cytoplasm and reduces hydrogen peroxide. GPX2 is intestinal and extracellular. GPX3 is abundant in plasma. GPX4 substrate is lipid hydroxyperoxide.
+
</StructureSection>
 +
== 3D Structures of glutathione peroxidase ==
-
{{TOC limit|limit=2}}
+
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
== 3D Structures of glutathione peroxidase ==
+
*GPX1
-
===GPX1===
+
**[[2f8a]] – hGPX1 (mutant) – human
-
[[2f8a]] – hGPX1 (mutant) – human
+
**[[3e0u]] – GPX1 – ''Trypanosoma cruzi''
-
[[3e0u]] – GPX1 – ''Trypanosoma cruzi''
+
*GPX2
-
===GPX2===
+
**[[2he3]] – hGPX2 (mutant)
-
[[2he3]] – hGPX2 (mutant)
+
*GPX3
-
===GPX3===
+
**[[2r37]] – hGPX3 (mutant)<br />
 +
**[[3cmi]] – GPX3 – yeast
-
[[2r37]] – hGPX3 (mutant)
+
*GPX4
-
[[3cmi]] – GPX3 – yeast
+
-
===GPX4===
+
**[[2gs3]], [[2obi]], [[6elw]], [[7l8k]], [[7l8l]], [[7l8m]], [[7l8q]], [[7l8r]], [[8q8j]], [[8q8n]] – hGPX4 (mutant)<br />
 +
**[[5h5q]] – hGPX4 + GXPEP-1<br />
 +
**[[5h5r]] – hGPX4 (mutant) + GXPEP-2<br />
 +
**[[5h5s]] – hGPX4 (mutant) + GXPEP-3<br />
 +
**[[6hkq]], [[6hn3]] – hGPX4 + inhibitor<br />
 +
**[[7u4i]], [[7u4j]], [[7u4k]], [[7u4l]], [[7u4m]], [[7u4n]] – hGPX4 (mutant) + inhibitor<br />
 +
**[[5l71]] – mGPX4 - mouse<br />
-
[[2gs3]], [[2obi]] – hGPX4 (mutant)
+
*GPX5
-
===GPX5===
+
**[[2i3y]] – hGPX5
-
[[2i3y]] – hGPX5
+
**[[2p5q]], [[2p5r]] – GPX5 – poplar
-
[[2p5q]], [[2p5r]] – GPX5 – poplar
+
*GPX6
-
===GPX7===
+
**[[7fc2]] – mGPX6<br />
-
[[2p31]] – hGPX7
+
*GPX7
-
===GPX8===
+
**[[2p31]] – hGPX7
-
[[3cyn]] – hGPX8
+
*GPX8
-
===GPX===
+
**[[3cyn]] – hGPX8
-
[[1gp1]] – GPX + amino-selenino-propionic acid – bovine
+
*GPX
-
[[2v1m]] – SmGPX – ''Schistosoma mansoni''
+
**[[1gp1]] – GPX + amino-selenino-propionic acid – bovine
-
[[2wgr]] – SmGPX (mutant)
+
**[[2v1m]] – SmGPX – ''Schistosoma mansoni''
 +
**[[2wgr]] – SmGPX (mutant)<br />
 +
**[[6vpd]] – GPX – ''Hypocrea jecorina''<br />
 +
}}
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Glutatione peroxidase 1 complex with glycerol and ammonium ion, 3e0u

Drag the structure with the mouse to rotate

3D Structures of glutathione peroxidase

Updated on 17-July-2025

References

  1. ↑ Arthur JR. The glutathione peroxidases. Cell Mol Life Sci. 2000 Dec;57(13-14):1825-35. PMID:11215509
  2. ↑ Lei XG, Cheng WH, McClung JP. Metabolic regulation and function of glutathione peroxidase-1. Annu Rev Nutr. 2007;27:41-61. PMID:17465855 doi:http://dx.doi.org/10.1146/annurev.nutr.27.061406.093716
  3. ↑ Ran Q, Liang H, Ikeno Y, Qi W, Prolla TA, Roberts LJ 2nd, Wolf N, Van Remmen H, Richardson A. Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J Gerontol A Biol Sci Med Sci. 2007 Sep;62(9):932-42. PMID:17895430
  4. ↑ Hall L, Williams K, Perry AC, Frayne J, Jury JA. The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract. Biochem J. 1998 Jul 1;333 ( Pt 1):5-9. PMID:9639555
  5. ↑ Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut. 2012 Sep;61(9):1250-60. doi: 10.1136/gutjnl-2011-301078. Epub 2011 Dec 9. PMID:22157330 doi:http://dx.doi.org/10.1136/gutjnl-2011-301078
  6. ↑ Saga Y, Ohwada M, Suzuki M, Konno R, Kigawa J, Ueno S, Mano H. Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. Oncol Rep. 2008 Dec;20(6):1299-303. PMID:19020706
  7. ↑ Ran Q, Gu M, Van Remmen H, Strong R, Roberts JL, Richardson A. Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity. J Neurosci Res. 2006 Jul;84(1):202-8. PMID:16673405 doi:http://dx.doi.org/10.1002/jnr.20868
  8. ↑ Peng D, Hu T, Soutto M, Belkhiri A, Zaika A, El-Rifai W. Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma. Gut. 2014 Apr;63(4):540-51. doi: 10.1136/gutjnl-2013-304612. Epub 2013 Apr 12. PMID:23580780 doi:http://dx.doi.org/10.1136/gutjnl-2013-304612

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

Retrieved from "http://52.214.119.220/wiki/index.php/Glutathione_peroxidase"
Personal tools