1w9d

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[[Image:1w9d.gif|left|200px]]
[[Image:1w9d.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1w9d |SIZE=350|CAPTION= <scene name='initialview01'>1w9d</scene>, resolution 1.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1w9d", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AGB:Gol+Binding+Site+For+Chain+M'>AGB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SEH:S-BENZYL+PHENYLACETOTHIOHYDROXIMATE-O-SULFATE'>SEH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioglucosidase Thioglucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.147 3.2.1.147] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1w9d| PDB=1w9d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9d OCA], [http://www.ebi.ac.uk/pdbsum/1w9d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w9d RCSB]</span>
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}}
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'''S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE'''
'''S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE'''
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[[Category: Rollin, P.]]
[[Category: Rollin, P.]]
[[Category: Tatibouet, A.]]
[[Category: Tatibouet, A.]]
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[[Category: glucotropaeolin]]
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[[Category: Glucotropaeolin]]
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[[Category: glusosinolate]]
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[[Category: Glusosinolate]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: myrosinase]]
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[[Category: Myrosinase]]
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[[Category: thio-glucoside]]
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[[Category: Thio-glucoside]]
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[[Category: thioglucosidase]]
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[[Category: Thioglucosidase]]
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[[Category: thioglycosidase]]
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[[Category: Thioglycosidase]]
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[[Category: thiohydroximate]]
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[[Category: Thiohydroximate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:20:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:33:07 2008''
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Revision as of 10:20, 3 May 2008

Image:1w9d.gif

Template:STRUCTURE 1w9d

S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE


Overview

Myrosinase, a thioglucoside glucohydrolase, is the only enzyme able to hydrolyse glucosinolates, a unique family of molecules bearing an anomeric O-sulfated thiohydroximate function. Non-hydrolysable myrosinase inhibitors have been devised and studied for their biological interaction. Diverse modifications of the O-sulfate moiety did not result in a significant inhibitory effect, whereas replacing the D-glucopyrano residue by its carba-analogue allowed inhibition to take place. X-Ray experiments carried out after soaking allowed for the first time inclusion of a non-hydrolysable inhibitor inside the enzymatic pocket. Structural tuning of the aglycon part in its pocket is being used as a guide for the development of simplified and more potent inhibitors.

About this Structure

1W9D is a Single protein structure of sequence from Sinapis alba. Full crystallographic information is available from OCA.

Reference

The glucosinolate-myrosinase system. New insights into enzyme-substrate interactions by use of simplified inhibitors., Bourderioux A, Lefoix M, Gueyrard D, Tatibouet A, Cottaz S, Arzt S, Burmeister WP, Rollin P, Org Biomol Chem. 2005 May 21;3(10):1872-9. Epub 2005 Apr 14. PMID:15889170 Page seeded by OCA on Sat May 3 13:20:26 2008

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