Gramicidin
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='1gmk' size='350' side='right' caption='Gramicidin A complex with thiocyanate and K+ ion (purple) (PDB entry [[1gmk]])' scene='44/444642/Cv/2'> |
== Function == | == Function == | ||
[[Gramicidin]] (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria ''Bacillus brevis''<ref>PMID:5288776</ref>.<br /> | [[Gramicidin]] (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria ''Bacillus brevis''<ref>PMID:5288776</ref>.<br /> | ||
* '''GCDN S''' is an antibiotic cyclic polypeptide.<br /> | * '''GCDN S''' is an antibiotic cyclic polypeptide.<br /> | ||
* '''GCDN D''' is a mixture of GCDN A, B, C. <br /> | * '''GCDN D''' is a mixture of GCDN A, B, C. <br /> | ||
| - | See theoretical model of [[Gramicidin Channel in Lipid Bilayer]]. | + | See theoretical model of [[Gramicidin Channel in Lipid Bilayer]] and [[Gramicidin Channel in Lipid Bilayer (Spanish)]]. |
==Relevance == | ==Relevance == | ||
GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive<ref>PMID:8836773</ref>. | GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive<ref>PMID:8836773</ref>. | ||
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| + | == Structural highlights: Gramicidin A== | ||
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| + | Protein: | ||
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| + | <scene name='44/444642/Cv/7'>Chains</scene>, chain A in green, chain B in salmon. | ||
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| + | Non-standard residues: | ||
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| + | <scene name='44/444642/Cv/8'>Ethanloamine</scene> | ||
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| + | <scene name='44/444642/Cv/9'>D-leucine</scene> | ||
| + | |||
| + | <scene name='44/444642/Cv/10'>D-valine</scene> | ||
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| + | <scene name='44/444642/Cv/11'>N-formyl-L-valine</scene> | ||
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| + | Ligands: | ||
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| + | <scene name='44/444642/Cv/4'>Methanol</scene>, C atom of methanol in cyan. | ||
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| + | <scene name='44/444642/Cv/5'>Thiocyanate</scene>, C atom of thiocyanate in magenta. | ||
| + | |||
| + | <scene name='44/444642/Cv/6'>K+ ion</scene> (in purple). | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Gramicidin == | == 3D Structures of Gramicidin == | ||
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**[[2xdc]], [[1w5u]], [[1bdw]], [[1al4]], [[1alx]], [[1alz]], [[2y5m]], [[2y6n]] – GCDN D<br /> | **[[2xdc]], [[1w5u]], [[1bdw]], [[1al4]], [[1alx]], [[1alz]], [[2y5m]], [[2y6n]] – GCDN D<br /> | ||
| - | **[[3lml]], [[2izq]], [[ | + | **[[3lml]], [[2izq]], [[4v6f]], [[3l8l]] - GCDN D + iodide<br /> |
**[[1c4d]] - GCDN D + CsCl<br /> | **[[1c4d]] - GCDN D + CsCl<br /> | ||
**[[3zq8]] – GCDN D + monovaccenin | **[[3zq8]] – GCDN D + monovaccenin | ||
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**[[1tk2]] – GCDN S + subtilisin savinase – ''Bacillus lentus'' | **[[1tk2]] – GCDN S + subtilisin savinase – ''Bacillus lentus'' | ||
| + | **[[8rc7]] – GCDN S + urea<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Gramicidin
Updated on 27-July-2025
References
- ↑ Urry DW, Goodall MC, Glickson JD, Mayers DF. The gramicidin A transmembrane channel: characteristics of head-to-head dimerized (L,D) helices. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1907-11. PMID:5288776
- ↑ Kondejewski LH, Farmer SW, Wishart DS, Hancock RE, Hodges RS. Gramicidin S is active against both gram-positive and gram-negative bacteria. Int J Pept Protein Res. 1996 Jun;47(6):460-6. PMID:8836773
