1wce
From Proteopedia
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'''CRYSTAL STRUCTURE OF THE T13 IBDV VIRAL PARTICLE REVEALS A MISSING LINK IN ICOSAHEDRAL VIRUSES EVOLUTION''' | '''CRYSTAL STRUCTURE OF THE T13 IBDV VIRAL PARTICLE REVEALS A MISSING LINK IN ICOSAHEDRAL VIRUSES EVOLUTION''' | ||
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[[Category: Pous, J.]] | [[Category: Pous, J.]] | ||
[[Category: Rey, F A.]] | [[Category: Rey, F A.]] | ||
| - | [[Category: | + | [[Category: Birnavirus]] |
| - | [[Category: | + | [[Category: Double-stranded rna virus protein]] |
| - | [[Category: | + | [[Category: Evolution]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Icosahedral virus]] |
| - | [[Category: | + | [[Category: Membrane translocation activity]] |
| - | [[Category: | + | [[Category: Non-enveloped icosahedral viruse]] |
| - | [[Category: | + | [[Category: Transcriptase machinery]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:27:38 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:27, 3 May 2008
CRYSTAL STRUCTURE OF THE T13 IBDV VIRAL PARTICLE REVEALS A MISSING LINK IN ICOSAHEDRAL VIRUSES EVOLUTION
Overview
Double-stranded RNA virions are transcriptionally competent icosahedral particles that must translocate across a lipid bilayer to function within the cytoplasm of the target cell. Birnaviruses are unique among dsRNA viruses as they have a single T = 13 icosahedral shell, lacking the characteristic inner capsid observed in the others. We determined the crystal structures of the T = 1 subviral particle (260 angstroms in diameter) and of the T = 13 intact virus particle (700 angstroms in diameter) of an avian birnavirus to 3 angstroms and 7 angstroms resolution, respectively. Our results show that VP2, the only component of the virus icosahedral capsid, is homologous both to the capsid protein of positive-strand RNA viruses, like the T = 3 nodaviruses, and to the T = 13 capsid protein of members of the Reoviridae family of dsRNA viruses. Together, these results provide important insights into the multiple functions of the birnavirus capsid and reveal unexpected structural relationships among icosahedral viruses.
About this Structure
1WCE is a Single protein structure of sequence from Infectious bursal disease virus. Full crystallographic information is available from OCA.
Reference
The birnavirus crystal structure reveals structural relationships among icosahedral viruses., Coulibaly F, Chevalier C, Gutsche I, Pous J, Navaza J, Bressanelli S, Delmas B, Rey FA, Cell. 2005 Mar 25;120(6):761-72. PMID:15797378 Page seeded by OCA on Sat May 3 13:27:38 2008
Categories: Infectious bursal disease virus | Single protein | Bressanelli, S. | Chevalier, C. | Coulibaly, F. | Delmas, B. | Gutsche, I. | Navaza, J. | Pous, J. | Rey, F A. | Birnavirus | Double-stranded rna virus protein | Evolution | Hydrolase | Icosahedral virus | Membrane translocation activity | Non-enveloped icosahedral viruse | Transcriptase machinery
