Heat Shock Protein structures

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Line 29: Line 29:
**[[4ylb]], [[4ylc]] - SsHsp20 (mutant)<br />
**[[4ylb]], [[4ylc]] - SsHsp20 (mutant)<br />
**[[5z81]] – VcHsp15 – ''Vibrio cholerae''<br />
**[[5z81]] – VcHsp15 – ''Vibrio cholerae''<br />
 +
**[[4i2n]] – VcHsp31<br />
**[[3bbu]] – EcHsp15 - ''Escherichia coli'' – Cryo-EM<br />
**[[3bbu]] – EcHsp15 - ''Escherichia coli'' – Cryo-EM<br />
 +
**[[1dm9]] – EcHsp15<br />
 +
**[[8ap4]] – EcHsp15 in 50S ribosome – Cryo-EM<br />
**[[1ons]] – EcHsp31<br />
**[[1ons]] – EcHsp31<br />
**[[3gla]], [[3gt6]], [[3guf]] – Hsp – ''Xanthomonas axonopodis''<br />
**[[3gla]], [[3gt6]], [[3guf]] – Hsp – ''Xanthomonas axonopodis''<br />
-
**[[3vqk]] – StHsp14 – ''Sulfolobus tokodaii''<br />
+
**[[3aac]], [[3vqk]] – StHsp14 – ''Sulfolobus tokodaii''<br />
-
**[[3vql]], [[3vqm]] – StHsp14 (mutant)<br />
+
**[[3aab]], [[3vql]], [[3vqm]] – StHsp14 (mutant)<br />
**[[3w1z]] – Hsp16 – ''Schizosacchromyces pombe''<br />
**[[3w1z]] – Hsp16 – ''Schizosacchromyces pombe''<br />
**[[5j7n]] – Hsp – ''Xylella fastidiosa''<br />
**[[5j7n]] – Hsp – ''Xylella fastidiosa''<br />
-
**[[1shs]], [[4eld]], [[4i88]] – Hsp – ''Methanococcus jannaschii''<br />
+
**[[6l6m]] – Hsp18.5 – ''Entamoeba histolytica''<br />
 +
**[[4fei]] – Hsp17.7 – ''Deinococcus radiodurans''<br />
 +
**[[1shs]], [[4eld]], [[4i88]] – MjHsp – ''Methanococcus jannaschii''<br />
 +
**[[9nv4]], [[9nv7]], [[9nv8]], [[9nvc]], [[9nvf]], [[9nvi]], [[9nvj]], [[9nvk]] – MjHsp16.5 <br />
 +
**[[8wp9]] – MjHsp16.5 – Cryo EM<br />
**[[2bol]] – Hsp – ''Taenia saginata''<br />
**[[2bol]] – Hsp – ''Taenia saginata''<br />
**[[5zul]] – MmaHsp – ''Mycobacterium marinum''<br />
**[[5zul]] – MmaHsp – ''Mycobacterium marinum''<br />
-
**[[5zs6]], [[5zs3]] – MmaHsp + peptide<br />
+
**[[5zs3]], [[5zs6]] – MmaHsp + peptide<br />
**[[7ck4]] – Hsp – ''Synechococcus'' phage<br />
**[[7ck4]] – Hsp – ''Synechococcus'' phage<br />
**[[6ewn]] – HspA – ''Thermosynechococcus vulcanus''<br />
**[[6ewn]] – HspA – ''Thermosynechococcus vulcanus''<br />
Line 45: Line 52:
*Hsp33
*Hsp33
 +
**[[3kkl]] – yHsp33 <br />
**[[1hw7]], [[3m7m]] – EcHsp33 NTD <br />
**[[1hw7]], [[3m7m]] – EcHsp33 NTD <br />
**[[1i7f]] – EcHsp33 chaperone domain (mutant)<br />
**[[1i7f]] – EcHsp33 chaperone domain (mutant)<br />
Line 53: Line 61:
*HslV, HslU, HslJ or ATP-dependent protease ATPase subunit HsIU
*HslV, HslU, HslJ or ATP-dependent protease ATPase subunit HsIU
-
**[[1e94]], [[1yyf]], [[1g4a]], [[1g4b]], [[1hqy]], [[1ht1]], [[1ht2]], [[5ji3]] – EcHslV+HslU <br />
+
**[[1e94]], [[1g4a]], [[1g4b]], [[1hqy]], [[1ht1]], [[1ht2]], [[1yyf]], [[5ji3]] – EcHslV+HslU <br />
**[[5txv]] – EcHslU<br />
**[[5txv]] – EcHslU<br />
-
**[[6pxl]], [[6pxk]] – EcHslU + ADP<br />
+
**[[6pxk]], [[6pxl]] – EcHslU + ADP<br />
**[[5ji2]], [[6pxi]] – EcHslV + EcHslU (mutant)<br />
**[[5ji2]], [[6pxi]] – EcHslV + EcHslU (mutant)<br />
**[[1ned]] – EcHslV<br />
**[[1ned]] – EcHslV<br />
Line 69: Line 77:
**[[2qld]] – hHsp40 residues 158-340<br />
**[[2qld]] – hHsp40 residues 158-340<br />
-
**[[1hdj]], [[2ctq]], [[6iws]] – hHsp40 J domain 1-76 - NMR<br />
+
**[[1hdj]], [[2ctq]], [[2lgw]], [[2m6y]], [[6iws]] – hHsp40 J domain 1-76 - NMR<br />
 +
**[[6byr]] – hHsp40 J domain 1-70 + CAMP-dependent protein kinase<br />
**[[6z5n]] – hHsp40 1-110 – NMR<br />
**[[6z5n]] – hHsp40 1-110 – NMR<br />
**[[6cgh]] – hHsp40 346-432 – NMR<br />
**[[6cgh]] – hHsp40 346-432 – NMR<br />
**[[6u3r]], [[6u3s]] – hHsp40 1-127+CT – NMR<br />
**[[6u3r]], [[6u3s]] – hHsp40 1-127+CT – NMR<br />
**[[7jsq]] – hHsp40 CT – NMR<br />
**[[7jsq]] – hHsp40 CT – NMR<br />
 +
**[[7ndx]] – hHsp40 CT + NudC peptide<br />
**[[7ciz]], [[7cj0]] – hHsp40 CT + DNA replication licensing factor + histone H3.4 + histone H4<br />
**[[7ciz]], [[7cj0]] – hHsp40 CT + DNA replication licensing factor + histone H3.4 + histone H4<br />
**[[6jmg]] – DnaJ + GTP - frog<br />
**[[6jmg]] – DnaJ + GTP - frog<br />
Line 90: Line 100:
*Hsp47
*Hsp47
-
**[[3zha]] – dHsp47 + collagen peptide - dog<br />
+
**[[4au4]] – dHsp47 - dog<br />
 +
**[[3zha]] – dHsp47 + collagen peptide<br />
* Hsp60 mitochondrial
* Hsp60 mitochondrial
-
**[[7azp]] – hHsp60 – Cryo EM<br />
+
**[[7azp]], [[7l7l]], [[7l7s]], [[8g7j]], [[9es3]] – hHsp60 – Cryo EM<br />
-
**[[4pj1]], [[6ht7]] – hHsp60 + hHsp10<br />
+
**[[8u39]] – hHsp60 (mutant) - Cryo EM
-
**[[6mrc]], [[6mrd]] – hHsp60 + hHsp10 + ADP – Cryo EM<br />
+
**[[9es6]] – hHsp60 + ADP – Cryo EM<br />
 +
**[[8g7k]] – hHsp60 (mutant) + ADP – Cryo EM
 +
**[[9es2]] – hHsp60 + ATP – Cryo EM
 +
**[[8g7l]], [[8g7m]], [[8g7o]] – hHsp60 (mutant) + ATP – Cryo EM
 +
**[[4pj1]], [[6ht7]] – hHsp60 + hHsp10 + ADP<br />
 +
**[[6mrc]], [[6mrd]], [[9es4]], [[9es5]] – hHsp60 + hHsp10 + ADP – Cryo EM<br />
 +
**[[9es0]], [[9es1]] – hHsp60 + hHsp10 + ATP – Cryo EM<br />
 +
**[[8g7n]] – hHsp60 (mutant) + hHsp10 + ATP – Cryo EM<br />
 +
**[[7v98]], [[7v9r]] – Hsp60 – Epinephelus coioides
-
* Hsp60 - the large subunit of the chaperonin molecule GroEL
+
* Hsp60 - the large subunit of the chaperonin molecule GroEL ; See [[Chaperonin]]
-
**[[3los]] – MmHsp60 - GroEL – ''Methanococcus maripaludis'' – closed state<br />
+
* Hsp65
-
**[[3iyf]] - MmHsp60 - GroEL – open state<br />
+
 
-
**[[3e76]] – EcHsp60 – GroEL+Tl ion – ''Escherichia coli''<br />
+
**[[3rtk]] – MtHsp65 – ''Mycobacterium tuberculosis''<br />
-
**[[2nwc]], [[1oel]], [[1grl]], [[1la1]] - EcHsp60 – GroEL<br />
+
-
**[[2eu1]] - EcHsp60 (mutant) – GroEL<br />
+
-
**[[2cgt]] - EcHsp60 – GroEL+ADP+capsid assembly protein Gp31<br />
+
-
**[[2c7c]], [[2c7d]] - EcHsp60 – GroEL+GroES – cryo EM<br />
+
-
**[[1gr5]] - EcHsp60 – GroEL – cryo EM<br />
+
-
**[[1gru]] - EcHsp60 – GroEL+ATP+GroES+ADP – cryo EM<br />
+
-
**[[1dkd]] - EcHsp60 – GroEL apical (top) domain (146 amino acids)+12-mer peptide<br />
+
-
**[[1dk7]], [[1jon]] - EcHsp60 – GroEL apical domain <br />
+
-
**[[1kid]] - EcHsp60 (mutant) – GroEL apical domain<br />
+
-
**[[1srv]] - TtHsp60 – GroEL apical domain<br />
+
-
**[[4v4o]] - TtHsp60 – GroEL+GroES <br />
+
-
**[[1ass]], [[1asx]] - Hsp60 – GroEL apical domain – ''Thermoplasma acidophilum''<br />
+
* Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641.
* Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641.
-
**[[5bn8]], [[2e88]], [[1s3x]], [[1hjo]], [[6g3s]], [[6g3r]], [[6fhk]] – hHsp70 NBD <br />
+
**[[1hjo]], [[1s3x]], [[2e88]], [[5bn8]], [[6fhk]], [[6g3r]], [[6g3s]] – hHsp70 NBD <br />
**[[5bn9]], [[5bpl]], [[5bpm]], [[5bpn]] – hHsp70 NBD (mutant)<br />
**[[5bn9]], [[5bpl]], [[5bpm]], [[5bpn]] – hHsp70 NBD (mutant)<br />
**[[3a8y]] – hHsp70 NBD+BAG domain regulator protein<br />
**[[3a8y]] – hHsp70 NBD+BAG domain regulator protein<br />
Line 126: Line 133:
**[[6b1m]] - hHsp70 NBD (mutant) + ANP<br />
**[[6b1m]] - hHsp70 NBD (mutant) + ANP<br />
**[[2e8a]] - hHsp70 NBD+AMPPNP<br />
**[[2e8a]] - hHsp70 NBD+AMPPNP<br />
-
**[[3jxu]], [[3i33]], [[3gdq]], [[3fe1]] - hHsp70 NBD+ADP+P<br />
+
**[[3fe1]], [[3gdq]], [[3i33]], [[3jku]] - hHsp70 NBD+ADP+P<br />
-
**[[3iuc]], [[3atu]], [[3atv]], [[3ay9]] - hHsp70 NBD+ADP<br />
+
**[[3atu]], [[3atv]], [[3ay9]], [[3iuc]] - hHsp70 NBD+ADP<br />
**[[3lof]] – hHsp70 CT<br />
**[[3lof]] – hHsp70 CT<br />
**[[4po2]] - hHsp70 CT + peptide<br />
**[[4po2]] - hHsp70 CT + peptide<br />
**[[2lmg]] – hHsp70 CT - NMR<br />
**[[2lmg]] – hHsp70 CT - NMR<br />
-
**[[3dob]], [[3dqg]], [[2op6]] - CeHsp70 SBD – ''Caenoharbditis elegans''<br />
 
-
**[[4i2w]] – CeHsp70 + myosin chaperone<br />
 
-
**[[2p32]] - CeHsp70 CT<br />
 
**[[1xqs]] – hHsp70 SBD + Hsp-binding protein core domain<br />
**[[1xqs]] – hHsp70 SBD + Hsp-binding protein core domain<br />
-
**[[4j8f]], [[4wv5]], [[5xi9]], [[5gjj]] - hHsp70 SBD<br />
+
**[[4j8f]], [[4wv5]], [[5gjj]], [[5xi9]] - hHsp70 SBD<br />
**[[5xir]] - hHsp70 SBD (mutant)<br />
**[[5xir]] - hHsp70 SBD (mutant)<br />
**[[4wv7]] - hHsp70 SBD + novolactone<br />
**[[4wv7]] - hHsp70 SBD + novolactone<br />
**[[1hx1]] - bHsp70 NBD + molecular chaperone regulator 1 BAG domain<br />
**[[1hx1]] - bHsp70 NBD + molecular chaperone regulator 1 BAG domain<br />
 +
**[[2op6]], [[3dob]], [[3dqg]] - CeHsp70 SBD – ''Caenoharbditis elegans''<br />
 +
**[[4i2w]] – CeHsp70 + myosin chaperone<br />
 +
**[[2p32]] - CeHsp70 CT<br />
**[[1q5l]] - EcHsp70 SBD +peptide - NMR<br />
**[[1q5l]] - EcHsp70 SBD +peptide - NMR<br />
-
**[[3gl1]] - ScHsp70 NBD – ''Saccharomyces cerevisiae''<br />
+
**[[7rax]] - EcHsp70 NBD + ATP <br />
-
**[[2d2e]], [[3d2f]] – ScHsp70 NBD+SSE1(Hsp110)<br />
+
**[[3gl1]] - yHsp70 NBD <br />
 +
**[[2d2e]], [[3d2f]] – yHsp70 NBD+SSE1(Hsp110)<br />
**[[3lca]] – yHsp70 Ssa1 CT+yTOM71<br />
**[[3lca]] – yHsp70 Ssa1 CT+yTOM71<br />
**[[2v7y]] – Hsp70 NBD+SBD – ''Geobacillus kaustophilus''<br />
**[[2v7y]] – Hsp70 NBD+SBD – ''Geobacillus kaustophilus''<br />
Line 147: Line 155:
**[[3kvg]] - CpHsp70 NBD+AMPPNP<br />
**[[3kvg]] - CpHsp70 NBD+AMPPNP<br />
**[[3l4i]] - CpHsp70 NBD+ADP+P<br />
**[[3l4i]] - CpHsp70 NBD+ADP+P<br />
 +
**[[8w1m]] – TtHsp70 NTD+ADP <br />
**[[6rzq]] – PfHsp70 NTD+ANP <br />
**[[6rzq]] – PfHsp70 NTD+ANP <br />
**[[6s02]] – PfHsp70 NTD+ADP <br />
**[[6s02]] – PfHsp70 NTD+ADP <br />
-
**[[7ooe]], [[7oog]], [[7ooh]], [[7p31]] – PfHsp70 NTD+AMP derivative + inhibitor <br />
+
**[[7ooe]], [[7oog]], [[7p31]] – PfHsp70 NTD+AMP derivative + inhibitor <br />
 +
**[[7nqr]], [[7nqs]], [[7nqu]], [[7nqz]] - PfHsp70 NBD + inhibitor<br />
**[[6zhi]] - PfHsp70 CT + peptide<br />
**[[6zhi]] - PfHsp70 CT + peptide<br />
 +
**[[8gb3]] - MtHsp70 + Grpe – Cryo EM<br />
*Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
*Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
Line 156: Line 167:
**[[6cz1]], [[6dfm]], [[6dfo]], [[6do2]], [[6dws]] - hBIP ATPase domain + adenosine derivative 26-407<br />
**[[6cz1]], [[6dfm]], [[6dfo]], [[6do2]], [[6dws]] - hBIP ATPase domain + adenosine derivative 26-407<br />
**[[6hab]] - haBIP (mutant) - hamster <br />
**[[6hab]] - haBIP (mutant) - hamster <br />
-
**[[6h9u]], [[6ha7]] - haBIP + mesencephalic atrocyte-derived neurotrophic factor - hamster <br />
+
**[[6h9u]], [[6ha7]] - haBIP + mesencephalic atrocyte-derived neurotrophic factor <br />
*DnaK or chaperone protein DnaK (Hsp70 from ''E. coli'') Domains: NBD 1-383; SBD 389-607
*DnaK or chaperone protein DnaK (Hsp70 from ''E. coli'') Domains: NBD 1-383; SBD 389-607
**[[4b9q]] - EcDnaK NBD + SBD + ATP<br />
**[[4b9q]] - EcDnaK NBD + SBD + ATP<br />
 +
**[[7ko2]], [[7krt]], [[7kru]], [[7krv]] - EcDnaK (mutant) + ATP<br />
**[[5oow]] - EcDnaK + AMPPCP<br />
**[[5oow]] - EcDnaK + AMPPCP<br />
**[[5nro]] – EcDnaK (mutant) + DnaJ<br />
**[[5nro]] – EcDnaK (mutant) + DnaJ<br />
Line 166: Line 178:
**[[1dkg]] - EcDnaK NBD (mutant) + nucleotide exchange factor<br />
**[[1dkg]] - EcDnaK NBD (mutant) + nucleotide exchange factor<br />
**[[4ani]] - EcDnaK NBD + SBD + nucleotide exchange factor<br />
**[[4ani]] - EcDnaK NBD + SBD + nucleotide exchange factor<br />
-
**[[1dkx]], [[1dkz]], [[4r5j]], [[4r5k]], [[4r5l]], [[4f01]] - EcDnaK NBD + sub<br />
+
**[[1dkx]], [[1dkz]], [[4f01]], [[4r5j]], [[4r5k]], [[4r5l]] - EcDnaK NBD + sub<br />
**[[4jn4]], [[4jne]] - EcDnaK NBD + SBD (mutant) + ATP<br />
**[[4jn4]], [[4jne]] - EcDnaK NBD + SBD (mutant) + ATP<br />
**[[4jnf]] - EcDnaK SBD (mutant) + ATP<br />
**[[4jnf]] - EcDnaK SBD (mutant) + ATP<br />
**[[1bpr]], [[1dg4]], [[2bpr]] - EcDnaK SBD – NMR<br />
**[[1bpr]], [[1dg4]], [[2bpr]] - EcDnaK SBD – NMR<br />
**[[1q5l]] - EcDnaK SBD + peptide – NMR<br />
**[[1q5l]] - EcDnaK SBD + peptide – NMR<br />
-
**[[3dpp]], [[3dpq]], [[3dpo]], [[1dky]], [[3qnj]], [[4e81]], [[4ezn]], [[4ezo]], [[4ezp]], [[4ezq]], [[4ezr]], [[4ezs]], [[4ezt]], [[4ezu]], [[4ezv]], [[4ezw]], [[4ezx]], [[4ezy]], [[4ezz]], [[4f00]], [[4hy9]], [[4hyb]], [[4jwc]], [[4jwd]], [[4jwe]], [[4jwi]], [[4r5i]], [[4f01]], [[7jmm]], [[7jn8]], [[7jn9]], [[7jne]], [[7n6j]], [[7n6k]], [[7n6l]], [[7n6m]] – EcDnaK SBD + peptide<br />
+
**[[1dky]], [[3dpo]], [[3dpp]], [[3dpq]], [[3qnj]], [[4e81]], [[4ezn]], [[4ezo]], [[4ezp]], [[4ezq]], [[4ezr]], [[4ezs]], [[4ezt]], [[4ezu]], [[4ezv]], [[4ezw]], [[4ezx]], [[4ezy]], [[4ezz]], [[4f00]], [[4f01]], [[4hy9]], [[4hyb]], [[4jwc]], [[4jwd]], [[4jwe]], [[4jwi]], [[4r5i]], [[7jmm]], [[7jn8]], [[7jn9]], [[7jne]], [[7n6j]], [[7n6k]], [[7n6l]], [[7n6m]] – EcDnaK SBD + peptide<br />
-
**[[7kzi]], [[7kzu]] – EcDnaK/peptide<br />
+
**[[7krw]], [[7kzi]], [[7kzu]] – EcDnaK/peptide<br />
**[[1q5l]] - EcDnaK SBD +peptide – NMR<br />
**[[1q5l]] - EcDnaK SBD +peptide – NMR<br />
**[[4r5g]] - EcDnaK CT + inhibitor<br />
**[[4r5g]] - EcDnaK CT + inhibitor<br />
Line 186: Line 198:
**[[5f3k]], [[5f5r]] – hHsp75 NTD<br />
**[[5f3k]], [[5f5r]] – hHsp75 NTD<br />
-
**[[5hph]] – hHsp75 residues 60-554<br />
+
**[[5hph]], [[7ulk]] – hHsp75 residues 60-554<br />
-
**[[4z1f]], [[4z1g]], [[4z1h]], [[4z1i]], [[5y3n]], [[5y3o]], [[7c04]], [[7c05]], [[7c7b]], [[7c7c]] – hHsp75 + inhibitor<br />
+
**[[4z1f]], [[4z1g]], [[4z1h]], [[4z1i]], [[5y3n]], [[5y3o]], [[7c04]], [[7c05]], [[7c7b]], [[7c7c]], [[7u8u]], [[7u8v]], [[7u8w]], [[7u8x]] – hHsp75 + inhibitor<br />
 +
**[[6xg6]] – hHsp75 residues 60-704 + ADP – Cryo EM<br />
 +
**[[7kck]], [[7klu]], [[7klv]] – hHsp75 residues 60-704 + AMPPNP – Cryo EM<br />
 +
**[[7kcl]], [[7kcm]] – hHsp75 residues 60-704 + SDHB + AMPPNP – Cryo EM<br />
*Hsp83
*Hsp83
 +
**[[8u1l]], [[8u1m]], [[8u1n]] – Hsp83 + ATP – cabbage looper – Cryo EM
**[[3u67]] – LmHsp83 NTD + ADP – ''Leishmania major''
**[[3u67]] – LmHsp83 NTD + ADP – ''Leishmania major''
-
* Hsp90 – 4 domains: N-terminus (NTD) residues 1-236; linker; middle (MD); C-terminus (CT)
+
* Hsp90 – 4 domains: N-terminus (NTD) residues 1-236; linker 237-283; middle (MD) 284-543; C-terminus (CT)
*''Hsp90-α NTD''
*''Hsp90-α NTD''
-
**[[3t0h]], [[5j2v]], [[6gpw]] - hHsp90 NTD – human<br />
+
**[[3t0h]], [[5j2v]], [[6gpw]], [[7s8y]], [[7s8z]], [[8jr6]], [[8ki4]], [[9imw]] - hHsp90 NTD <br />
-
**[[5j80]], [[6gr4]], [[6gp4]] - hHsp90 NTD (mutant)<br />
+
**[[5j80]], [[6gp4]], [[6gr4]], [[8jr7]], [[8jra]], [[8x2r]] - hHsp90 NTD (mutant)<br />
-
**[[2h8m]], [[2hch]], [[2gqp]] – dHsp90B1 NTD <br />
+
**[[2gqp]], [[2h8m]], [[2hch]] – dHsp90B1 NTD <br />
**[[1yt1]], [[1yt2]] - dHsp90B1 NTD (mutant) <br />
**[[1yt1]], [[1yt2]] - dHsp90B1 NTD (mutant) <br />
-
**[[4x9l]] - Hsp90 NTD - rice<br />
+
**[[4x9l]] - riHsp90 NTD - rice<br />
**[[3h80]] – LmHsp90 NTD <br />
**[[3h80]] – LmHsp90 NTD <br />
**[[4gqt]] – CeHsp90 NTD<br />
**[[4gqt]] – CeHsp90 NTD<br />
Line 207: Line 223:
*''Hsp90-α NTD complexes''
*''Hsp90-α NTD complexes''
-
**[[6gqr]], [[3t0z]], [[3t2s]], [[3t10]], [[3t1k]], [[6gq6]], [[6gpy]], [[6gpt]], [[6gpr]], [[1byq]] - hHsp90-α NTD + nucleotide<br />
+
**[[1byq]], [[3t0z]], [[3t10]], [[3t1k]], [[3t2s]], [[6gq6]], [[6gpr]], [[6gpt]], [[6gpy]], [[6gqr]], [[7s90]] - hHsp90-α NTD + nucleotide<br />
-
**[[6gr5]], [[6gr3]], [[6gr1]], [[6gqu]], [[6gqs]], [[6gpp]], [[6gpo]], [[6gph]], [[6gpf]], [[6gp8]] - hHsp90-α NTD (mutant) + nucleotide<br />
+
**[[6gp8]], [[6gpf]], [[6gph]], [[6gpo]], [[6gpp]], [[6gqs]], [[6gqu]], [[6gr1]], [[6gr3]], [[6gr5]] - hHsp90-α NTD (mutant) + nucleotide<br />
-
**[[3k97]], [[3hek]], [[3mnq]] – hHsp90 NTD+pyrrolidin derivative <br />
+
**[[3hek]], [[3k97]], [[3mnq]] – hHsp90 NTD+pyrrolidin derivative <br />
**[[3k98]], [[3k99]], [[3qtf]], [[5lo5]], [[7lsz]], [[7lt0]] - hHsp90 NTD+indole derivative<br />
**[[3k98]], [[3k99]], [[3qtf]], [[5lo5]], [[7lsz]], [[7lt0]] - hHsp90 NTD+indole derivative<br />
**[[3r91]] - hHsp90 NTD (mutant) +indole derivative<br />
**[[3r91]] - hHsp90 NTD (mutant) +indole derivative<br />
**[[3hhu]], [[4jql]] - hHsp90 NTD+ carbamic acid derivative<br />
**[[3hhu]], [[4jql]] - hHsp90 NTD+ carbamic acid derivative<br />
-
**[[3ft8]], [[3ft5]], [[4cwf]], [[4cwn]], [[4cwo]], [[4cwp]], [[4cwq]], [[4cwr]], [[4cws]], [[4cwt]], [[6ei5]], [[5od7]] - hHsp90 NTD+quinazoline derivative inhibitor<br />
+
**[[3ft5]], [[3ft8]], [[4cwf]], [[4cwn]], [[4cwo]], [[4cwp]], [[4cwq]], [[4cwr]], [[4cws]], [[4cwt]], [[5od7]], [[6ei5]] - hHsp90 NTD+quinazoline derivative inhibitor<br />
**[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
**[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
**[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
**[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
-
**[[3bm9]], [[3bmy]], [[5xre]], [[5xrb]], [[5xr9]], [[5xr5]], [[5xqe]], [[5xqd]] - hHsp90 NTD+ oxazole derivative<br />
+
**[[3bm9]], [[3bmy]], [[5xqd]], [[5xqe]], [[5xr5]], [[5xr9]], [[5xrb]], [[5xrd]], [[5xre]] - hHsp90 NTD+ oxazole derivative<br />
**[[2of6]], [[3b24]], [[3b27]], [[3b28]], [[3r92]] - hHsp90 NTD+triazine derivative<br />
**[[2of6]], [[3b24]], [[3b27]], [[3b28]], [[3r92]] - hHsp90 NTD+triazine derivative<br />
-
**[[5j20]], [[5j27]], [[5j2x]], [[5j64]], [[5j6l]], [[5j6m]], [[5j82]], [[5j86]], [[5j8m]], [[5j6n]], [[5j8u]], [[5j9x]] - hHsp90-α NTD - hHsp90-a NTD+triazol derivative<br />
+
**[[5j20]], [[5j27]], [[5j2x]], [[5j64]], [[5j6l]], [[5j6m]], [[5j6n]], [[5j82]], [[5j86]], [[5j8m]], [[5j8u]], [[5j9x]], [[8agi]], [[8agl]] - hHsp90-α NTD +triazol derivative<br />
-
**[[2qfo]], [[3nmq]], [[3r4m]], [[3r4n]], [[3r4o]], [[3r4p]], [[3b25]], [[3b26]], [[2jcc]], [[3rlp]], [[3rlq]], [[3rlr]], [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]], [[2jjc]], [[5fnc]] - hHsp90 NTD+pyrimidine derivative<br />
+
**[[8agj]] - hHsp90-a NTD (mutant) +triazol derivative<br />
 +
**[[2jcc]], [[2jjc]], [[2qfo]], [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]], [[3b25]], [[3b26]], [[3nmq]], [[3r4m]], [[3r4n]], [[3r4o]], [[3r4p]], [[3rlp]], [[3rlq]], [[3rlr]], [[5fnc]], [[7dmc]], [[7s98]], [[7s99]], [[7s9f]], [[7s9g]], [[7s9h]], [[7s9i]] - hHsp90 NTD+pyrimidine derivative<br />
 +
**[[7a90]], [[7s95]] - hHsp90 NTD+ adenine <br />
**[[6f1n]] - hHsp90 NTD+pyridine derivative<br />
**[[6f1n]] - hHsp90 NTD+pyridine derivative<br />
-
**[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]], [[6el5]], [[2fwy]], [[2fwz]], [[2h55]], [[3o0i]], [[6cyh]], [[6cyg]], [[6b9a]], [[6b99]] - hHsp90 NTD+purine derivative<br />
+
**[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]], [[2fwy]], [[2fwz]], [[2h55]], [[3o0i]], [[6b99]], [[6b9a]], [[6cyg]], [[6cyh]], [[6el5]] - hHsp90 NTD+purine derivative<br />
-
**[[6n8x]] - hHsp90-a residues 123-358 + purine derivative<br />
+
**[[6n8x]], [[8sbt]] - hHsp90-a residues 123-358 + purine derivative<br />
**[[6olx]] - hHsp90-a residues 123-358 (mutant) + purine derivative<br />
**[[6olx]] - hHsp90-a residues 123-358 (mutant) + purine derivative<br />
-
**[[2qg0]], [[2bz5]] - hHsp90 NTD+sulfonamide derivative<br />
+
**[[2bz5]], [[2qg0]] - hHsp90 NTD+sulfonamide derivative<br />
**[[2yi0]], [[2yi5]], [[2yi6]], [[2yi7]], [[5fnd]] - hHsp90 NTD + thiadiazole derivative<br />
**[[2yi0]], [[2yi5]], [[2yi6]], [[2yi7]], [[5fnd]] - hHsp90 NTD + thiadiazole derivative<br />
-
**[[4hy6]], [[6ey8]], [[6ey9]], [[6eya]], [[6eyb]], [[5odx]], [[5oci]], [[5nyh]], [[5lny]], [[5lnz]], [[5lo0]], [[5lo1]], [[5lo6]], [[6lti]], [[6ltk]] - hHsp90 NTD + indazole derivative<br />
+
**[[4hy6]], [[5oci]], [[5odx]], [[5nyh]], [[5lny]], [[5lnz]], [[5lo0]], [[5lo1]], [[5lo6]], [[6ey8]], [[6ey9]], [[6eya]], [[6eyb]], [[6lti]], [[6ltk]] - hHsp90 NTD + indazole derivative<br />
**[[5nyi]] - hHsp90 NTD + resorcinol derivative<br />
**[[5nyi]] - hHsp90 NTD + resorcinol derivative<br />
-
**[[2qg2]], [[2cvi]], [[2cvj]], [[2uwd]], [[4b7p]] - hHsp90 NTD+oxazole derivative<br />
+
**[[2cvi]], [[2cvj]], [[2qg2]], [[2uwd]], [[4b7p]] - hHsp90 NTD+oxazole derivative<br />
**[[3d0b]], [[3rkz]], [[3wq9]] - hHsp90 NTD+benzamide derivative<br />
**[[3d0b]], [[3rkz]], [[3wq9]] - hHsp90 NTD+benzamide derivative<br />
**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
-
**[[2ccs]], [[2cct]], [[2ccu]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]], [[1yc1]], [[1yc4]], [[6eln]], [[6elo]], [[6elp]], [[6fcj]], [[5zr3]], [[5zrd]] - hHsp90 NTD+pyrazol derivative<br />
+
**[[1yc1]], [[1yc3]], [[1yc4]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[2ccs]], [[2cct]], [[2ccu]], [[5zr3]], [[5zrd]] [[6eln]], [[6elo]], [[6elp]], [[6fcj]] - hHsp90 NTD+pyrazol derivative<br />
-
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[4awo]], [[4awp]], [[4awq]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]], [[3wha]], [[4bqg]], [[4bqj]], [[4l8z]], [[4l90]], [[4l91]], [[4l93]], [[4lwe]], [[4l94]], [[4lwf]], [[4lwg]], [[4lwh]], [[4lwi]], [[4nh7]], [[4nh8]], [[4nh9]], [[4o09]], [[4o0b]], [[4r3m]], [[4u93]], [[4w7t]], [[4xip]], [[4xiq]], [[4xir]], [[4xit]], [[4ykq]], [[4ykr]], [[4ykt]], [[4yku]], [[4ykw]], [[4ykx]], [[4yky]], [[4ykz]], [[5cf0]], [[5fnf]], [[5ggz]], [[5m4e]], [[5m4h]], [[6ceo]], [[5vyy]], [[5t21]], [[5lq9]], [[5lr1]], [[5lr7]], [[5lrl]], [[5lrz]], [[5ls1]], [[5h22]], [[6hhr]], [[6lr9]], [[6lt8]], [[6tn4]], [[6tn5]], [[6u98]], [[6u99]], [[6u9a]], [[6u9b]] - hHsp90 NTD + inhibitor<br />
+
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[3wha]], [[4awo]], [[4awp]], [[4awq]], [[4bqg]], [[4bqj]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]], [[4l8z]], [[4l90]], [[4l91]], [[4l93]], [[4l94]], [[4lwe]], [[4lwf]], [[4lwg]], [[4lwh]], [[4lwi]], [[4nh7]], [[4nh8]], [[4nh9]], [[4o09]], [[4o0b]], [[4r3m]], [[4u93]], [[4w7t]], [[4xip]], [[4xiq]], [[4xir]], [[4xit]], [[4ykq]], [[4ykr]], [[4ykt]], [[4yku]], [[4ykw]], [[4ykx]], [[4yky]], [[4ykz]], [[5cf0]], [[5fnf]], [[5ggz]], [[5h22]], [[5lq9]], [[5lr1]], [[5lr7]], [[5lrl]], [[5lrz]], [[5ls1]], [[5m4e]], [[5m4h]], [[5t21]], [[5vyy]], [[6ceo]], [[6hhr]], [[6lr9]], [[6lt8]], [[6tn4]], [[6tn5]], [[6u98]], [[6u99]], [[6u9a]], [[6u9b]], [[7h9k]], [[7h9l]], [[7h9m]], [[7h9n]], [[7h9o]], [[7h9p]], [[7h9r]], [[7h9s]], [[7h9t]], [[7h9u]], [[7h9v]], [[7h9w]], [[7h9x]], [[7h9y]], [[7h9z]], [[7ha0]], [[7ha1]], [[7ha2]], [[7ha3]], [[7ha4]], [[7ha5]], [[7ha7]], [[7ha8]], [[7ha9]], [[7hab]], [[7hac]], [[7had]], [[7hae]], [[7haf]], [[7hag]], [[7hah]], [[7haj]], [[7hak]], [[7hal]], [[7ham]], [[7han]], [[7hao]], [[7hap]], [[7haq]], [[7har]], [[7has]], [[7hat]], [[7hau]], [[7haw]], [[7hax]], [[7hay]], [[7haz]], [[7hb0]], [[7hb1]], [[7hb2]], [[7hb3]], [[7hb4]], [[7hb6]], [[7hb8]], [[7hb9]], [[7hba]], [[7hbb]], [[7hbc]], [[7hbd]], [[7hbe]], [[7hbf]], [[7hbg]], [[7hbh]], [[7hbj]], [[7hbk]], [[7hbl]], [[7hbn]], [[7hbp]], [[7hbq]], [[7hbs]], [[7hbt]], [[7hbu]], [[7hbv]], [[7hbw]], [[7hbx]], [[7hby]], [[7hbz]], [[7hc0]], [[7hc1]], [[7hc2]], [[7hc3]], [[8w4v]], [[8w8k]], [[9auu]] - hHsp90 NTD + inhibitor<br />
-
**[[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[2xdx]], [[2xdu]], [[2xds]], [[2xdl]], [[2xdk]], [[2xab]], [[2vcj]], [[2vci]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]], [[2af6]] - hHsp90 NTD+ antigen<br />
+
**[[2af6]], [[2vcj]], [[2vci]], [[2xab]], [[2xdk]], [[2xdl]], [[2xds]], [[2xdu]], [[2xdx]], [[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]] - hHsp90 NTD+ antigen<br />
**[[1osf]], [[1yer]], [[1yes]], [[1yet]], [[6lsz]] - hHsp90 NTD+ drug <br />
**[[1osf]], [[1yer]], [[1yes]], [[1yet]], [[6lsz]] - hHsp90 NTD+ drug <br />
-
**[[2hg1]], [[2gfd]], [[2fyp]], [[2exl]], [[1u0z]], [[1qy8]], [[1ysz]], [[1u2o]], [[6d28]], [[6d1x]], [[1qye]], [[3o2f]], [[6d1x]], [[6d28]] - dHsp90B1 NTD+ligand<br />
+
**[[1qy8]], [[1qye]], [[1u0z]], [[1u2o]], [[1ysz]], [[2hg1]], [[2gfd]], [[2fyp]], [[2exl]], [[3o2f]], [[6d28]], [[6d1x]] - dHsp90B1 NTD+ligand<br />
**[[2esa]] - dHsp90B1 NTD (mutant) +ligand<br />
**[[2esa]] - dHsp90B1 NTD (mutant) +ligand<br />
-
**[[1yt0]], [[1tc6]], [[1tba]], [[1tc0]] - dHsp90B1 NTD+ nucleotide<br />
+
**[[1tba]], [[1tc0]], [[1tc6]], [[1yt0]] - dHsp90B1 NTD+ nucleotide<br />
**[[5wmt]], [[6aol]], [[6aom]], [[6asq]], [[6baw]], [[6c91]], [[6cyi]] - dHsp90B1 NTD+ inhibitor<br />
**[[5wmt]], [[6aol]], [[6aom]], [[6asq]], [[6baw]], [[6c91]], [[6cyi]] - dHsp90B1 NTD+ inhibitor<br />
**[[6asp]] - dHsp90B1 NTD + drug <br />
**[[6asp]] - dHsp90B1 NTD + drug <br />
Line 248: Line 266:
**[[3ied]] - PfHsp90 NTD+ANP <br />
**[[3ied]] - PfHsp90 NTD+ANP <br />
**[[3k60]] - PfHsp90 NTD+ADP<br />
**[[3k60]] - PfHsp90 NTD+ADP<br />
-
**[[6cji]] – CaHsp90 NTD – ''Candida albicans''<br />
 
-
**[[6cjl]], [[6cjp]] – CaHsp90 NTD + radicicol<br />
 
-
**[[6cjj]] – CaHsp90 NTD + ADP<br />
 
-
**[[6cjr]], [[6cjs]] – CaHsp90 NTD + inhibitor<br />
 
**[[7k9s]], [[7k9u]], [[7k9v]], [[7k9w]] – CnHsp90 NTD + inhibitor<br />
**[[7k9s]], [[7k9u]], [[7k9v]], [[7k9w]] – CnHsp90 NTD + inhibitor<br />
 +
 +
*''Hsp90-a NTD+linker residues 1-293''
 +
 +
**[[7ur3]] - hHsp90 + inhibitor <br />
*''Hsp90-α MD''
*''Hsp90-α MD''
 +
**[[6ksq]] - hHsp90 MD <br />
**[[2gq0]] - EcHsp90 MD<br />
**[[2gq0]] - EcHsp90 MD<br />
Line 269: Line 288:
*''Hsp90-α MD + CT'' residues 293-732
*''Hsp90-α MD + CT'' residues 293-732
-
**[[3q6m]], [[3q6n]] - hHsp90 MD + CT<br />
+
**[[3q6m]], [[3q6n]], [[7rxz]], [[7ry0]], [[7ry1]] - hHsp90 MD + CT<br />
**[[2o1t]] – dHsp90B1 MD+CT<br />
**[[2o1t]] – dHsp90B1 MD+CT<br />
-
*''Hsp90-α full length''
+
*''Hsp90-α full length 1-732''
-
**[[6xg6]] - hHsp90 + ADP – Cryo EM <br />
 
**[[2qf6]] - hHsp90 + antigen<br />
**[[2qf6]] - hHsp90 + antigen<br />
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br />
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br />
 +
**[[7l7j]] - hHsp90 + P23 + ANP – Cryo EM <br />
 +
**[[7krj]] - hHsp90 + GR + P23 + ATP – Cryo EM <br />
 +
**[[8ffv]], [[8ffw]] - hHsp90 + GR + FKBP54 + ATP – Cryo EM <br />
 +
**[[8h77]] - hHsp90 + AhR + P23 + XAP2 + ADP – Cryo EM <br />
 +
**[[7l7i]] - hHsp90 + FKBP51 + P23 + ANP – Cryo EM <br />
 +
**[[7kw7]] - hHsp90 + Hsp70 + GR + STI1 + ADP – Cryo EM <br />
**[[2o1u]] – dHsp90B1+AMPPNP<br />
**[[2o1u]] – dHsp90B1+AMPPNP<br />
**[[2o1v]] - dHsp90B1+ADP<br />
**[[2o1v]] - dHsp90B1+ADP<br />
Line 282: Line 306:
**[[2ioq]] - EcHsp90 <br />
**[[2ioq]] - EcHsp90 <br />
-
*Hsp90-β
+
*Hsp90-beta
 +
**[[8eob]] - hHsp90 – Cryo EM <br />
**[[6n8w]] - hHsp90 NTD <br />
**[[6n8w]] - hHsp90 NTD <br />
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br />
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br />
-
**[[1uym]], [[6n8y]] - hHsp90 NTD+ purine inhibitor<br />
+
**[[1uym]], [[6n8y]], [[7ulj]] - hHsp90 NTD+ purine inhibitor<br />
-
**[[5uc4]], [[5uch]], [[5uci]], [[5ucj]], [[4o04]], [[4o05]], **[[4o07]] - hHsp90-b NTD + inhibitor<br />
+
**[[4o04]], [[4o05]], [[4o07]], [[5uc4]], [[5uch]], [[5uci]], [[5ucj]] - hHsp90-b NTD + inhibitor<br />
**[[3nmq]] - hHsp90 NTD+pyrimidine derivative
**[[3nmq]] - hHsp90 NTD+pyrimidine derivative
**[[3pry]] – hHsp90 MD<br />
**[[3pry]] – hHsp90 MD<br />
 +
**[[7zub]], [[8qmo]] - hHsp90 + AIP + AH receptor + ADP - Cryo EM <br />
 +
**[[8eoa]] - hHsp90 + AIPL1 + ANP – Cryo EM <br />
 +
**[[7z37]], [[7z38]] - hHsp90 + Cdc37 + RAF-1 – Cryo EM <br />
 +
**[[8gae]], [[8gft]] - hHsp90 + Cdc37 + RAF-1 + PP5 – Cryo EM <br />
 +
**[[7zr0]] - hHsp90 + Cdc37 + BRAF – Cryo EM <br />
 +
**[[8fx4]] - hHsp90 + Cdc37 + GC-C – Cryo EM <br />
 +
**[[7zr5]], [[7zr6]] - hHsp90 + Cdc37 + BRAF + PP5 – Cryo EM <br />
 +
**[[7y04]] - mHsp90 + AH receptor + P23 + ADP - mouse - Cryo EM <br />
 +
 +
* Hsp90 homolog
 +
 +
**[[6cji]] – CaHsp90H NTD – ''Candida albicans''<br />
 +
**[[6cjl]], [[6cjp]] – CaHsp90H NTD + radicicol<br />
 +
**[[6cjj]] – CaHsp90H NTD + ADP<br />
 +
**[[9mtb]] – CaHsp90H NTD + ANP<br />
 +
**[[6cjr]], [[6cjs]], [[9msq]], [[9msu]], [[9msv]], [[8msx]], [[9mt3]], [[9mt9]] – CaHsp90H NTD + inhibitor<br />
* Hsp82 is the yeast equivalent of Hsp90 in mammals
* Hsp82 is the yeast equivalent of Hsp90 in mammals
Line 298: Line 339:
**[[2wep]] – yHsp82 NTD (mutant)+ADP<br />
**[[2wep]] – yHsp82 NTD (mutant)+ADP<br />
**[[2akp]], [[3c0e]] - yHsp82 NTD (mutant)<br />
**[[2akp]], [[3c0e]] - yHsp82 NTD (mutant)<br />
-
**[[1weq]], [[3c11]], [[2yga]], [[2wer]], [[2yge]], [[2ygf]] - yHsp82 NTD (mutant)+ antibiotic<br />
+
**[[1weq]], [[2yga]], [[2yge]], [[2ygf]], [[3c11]] - yHsp82 NTD (mutant)+ antibiotic<br />
-
**[[2iws]], [[2iwu]], [[2iwx]], [[2cgf]], 1bgq, [[2fxs]], [[4as9]], [[4asa]], [[4asb]], [[4asf]], [[4asg]], [[2weq]], [[1ah4]], [[1bgq]] - yHsp82 NTD +antibiotic<br />
+
**[[1ah4]], [[1bgq]], [[2cgf]], [[2fxs]], [[2iws]], [[2iwu]], [[2iwx]], [[2weq]], [[4as9]], [[4asa]], [[4asb]], [[4asf]], [[4asg]] - yHsp82 NTD +antibiotic<br />
 +
**[[8oxu]] - yHsp82 NTD + inhibitor <br />
**[[2vw5]], [[2vwc]] - yHsp82 NTD +7-o-carbamoylpremacbecin<br />
**[[2vw5]], [[2vwc]] - yHsp82 NTD +7-o-carbamoylpremacbecin<br />
**[[2fxs]] - yHsp82 NTD +radamide<br />
**[[2fxs]] - yHsp82 NTD +radamide<br />
Line 314: Line 356:
* Hsp100 are named ClpA or ClpB or ClpC or ClpL or ClpP
* Hsp100 are named ClpA or ClpB or ClpC or ClpL or ClpP
-
**[[1r6b]], [[1ksf]] – EcClpA (mutant) <br />
+
**[[1ksf]], [[1r6b]] – EcClpA (mutant) <br />
-
**[[1r6c]], [[1k6k]] – EcClpA N-terminal <br />
+
**[[1k6k]], [[1r6c]] – EcClpA N-terminal <br />
**[[1r6o]], [[1r6q]] – EcClpA N-terminal + ClpS<br />
**[[1r6o]], [[1r6q]] – EcClpA N-terminal + ClpS<br />
-
**[[1mg9]], [[1lzw]], [[1mbu]], [[1mbv]], [[1mbx]] – EcClpA + YLJA<br />
+
**[[1lzw]], [[1mbu]], [[1mbv]], [[1mbx]], [[1mg9]] – EcClpA + YLJA<br />
**[[6w1z]], [[6w20]], [[6w21]], [[6w22]], [[6w23]], [[6w24]] – EcClpA + RepA + GFP + ADP + ATP – Cryo EM<br />
**[[6w1z]], [[6w20]], [[6w21]], [[6w22]], [[6w23]], [[6w24]] – EcClpA + RepA + GFP + ADP + ATP – Cryo EM<br />
**[[6uqe]], [[6uqo]] – EcClpA + ClpP + RepA + GFP + ADP + ATPgS – Cryo EM<br />
**[[6uqe]], [[6uqo]] – EcClpA + ClpP + RepA + GFP + ADP + ATPgS – Cryo EM<br />
**[[4ciu]] - EcClpB (mutant)<br />
**[[4ciu]] - EcClpB (mutant)<br />
-
**[[4d2u]], [[4d2x]], [[4d2q]] - EcClpB – Cryo EM<br />
+
**[[4d2q]], [[4d2u]], [[4d2x]] - EcClpB – Cryo EM<br />
-
**[[5og1]], [[5ofo]] - EcClpB + ATPgS – Cryo EM<br />
+
**[[5ofo]], [[5og1]] - EcClpB + ATPgS – Cryo EM<br />
-
**[[6qs8]], [[6qs7]], [[6qs6]], [[6og3]] - EcClpB (mutant) + casein – Cryo EM<br />
+
**[[6og3]], [[6qs6]], [[6qs7]], [[6qs8]] - EcClpB (mutant) + casein – Cryo EM<br />
**[[6og2]] - EcClpB (mutant) + ADP – Cryo EM<br />
**[[6og2]] - EcClpB (mutant) + ADP – Cryo EM<br />
**[[6og1]] - EcClpB (mutant) + ADP + ATPgS – Cryo EM<br />
**[[6og1]] - EcClpB (mutant) + ADP + ATPgS – Cryo EM<br />
Line 331: Line 373:
**[[1khy]] – EcClpB NTD <br />
**[[1khy]] – EcClpB NTD <br />
**[[1jbk]] – EcClpB nucleotide binding domain 1<br />
**[[1jbk]] – EcClpB nucleotide binding domain 1<br />
 +
**[[1yg6]] – EcClpP<br />
 +
**[[1yg8]], [[3hln]] – EcClpP (mutant)<br />
 +
**[[2fzs]], [[7mk5]] – EcClpP + inhibitor<br />
 +
**[[6nb1]] – EcClpP + activator<br />
 +
**[[3mt6]] – EcClpP + Adep1<br />
 +
**[[6wr2]], [[6wsg]] – EcClpP + ClpX – Cryo EM<br />
 +
**[[6wrf]] – EcClpP + ClpX + GFP – Cryo EM<br />
 +
**[[8et3]] – EcClpP + ClpX + GFP + SSPB – Cryo EM<br />
**[[4iod]], [[4irf]] - PfClpB <br />
**[[4iod]], [[4irf]] - PfClpB <br />
**[[1qvr]] - TtClpB <br />
**[[1qvr]] - TtClpB <br />
Line 356: Line 406:
**[[7m1l]], [[7m1m]] – ClpP2 – ''Pseudomonas aeruginosa''<br />
**[[7m1l]], [[7m1m]] – ClpP2 – ''Pseudomonas aeruginosa''<br />
**[[6cfd]] – ClpP + antibiotic – ''Enterococcus faecium''<br />
**[[6cfd]] – ClpP + antibiotic – ''Enterococcus faecium''<br />
 +
**[[7tfm]] – ClpP N-domain – ''Leishmania mexicana''<br />
-
*Hsp101
+
*Hsp101 or chaperone protein ClpB1
 +
**[[9ip0]] – riHsp101 - Cryo EM<br />
**[[6e11]], [[6e10]] – PfPTEX core – Cryo EM<br />
**[[6e11]], [[6e10]] – PfPTEX core – Cryo EM<br />
*Hsp104
*Hsp104
-
**[[5kne]], [[6n8z]], [[6n8v]], [[6n8t]] – yHsp104 - Cryo EM<br />
+
**[[5kne]], [[6n8t]], [[6n8v]], [[6n8z]] – yHsp104 - Cryo EM<br />
**[[6ahf]] – yHsp104 (mutant) – Cryo EM<br />
**[[6ahf]] – yHsp104 (mutant) – Cryo EM<br />
-
**[[5u2u]], [[6amn]], [[5wbw]] – yHsp104 NTD<br />
+
**[[5u2u]], [[5wbw]], [[6amn]] – yHsp104 NTD<br />
**[[5vy8]] – yHsp104 + ADP<br />
**[[5vy8]] – yHsp104 + ADP<br />
**[[5vy9]], [[5vya]] – yHsp104 + casein<br />
**[[5vy9]], [[5vya]] – yHsp104 + casein<br />
**[[5vjh]] – yHsp104 + casein + ATP-γ-S<br />
**[[5vjh]] – yHsp104 + casein + ATP-γ-S<br />
-
**[[5u2l]] – Hsp104 NTD – ''Candida albicans''<br />
+
**[[5u2l]] – CaHsp104 NTD – ''Candida albicans''<br />
**[[6d00]] – CtHsp104 – ''Calcarisporiella thermophila'' - Cryo EM<br />
**[[6d00]] – CtHsp104 – ''Calcarisporiella thermophila'' - Cryo EM<br />
**[[6azy]] – CtHsp104 (mutant)<br />
**[[6azy]] – CtHsp104 (mutant)<br />
-
**[[5zui]] – Hsp104 – ''Chaetomium thermophilum''<br />
+
**[[5zui]] – ChtHsp104 – ''Chaetomium thermophilum''<br />
 +
**[[7cg3]] – ChtHsp104 - Cryo EM<br />
 +
**[[5d4w]] – ChtHsp104 (mutant)<br />
* Hsp110 in mammals is named Sse1, Sse2 in yeast
* Hsp110 in mammals is named Sse1, Sse2 in yeast
**[[6gfa]] – hHsp110 + ATP<br />
**[[6gfa]] – hHsp110 + ATP<br />
-
**[[3d2e]], [[3d2f]], [[3c7n]] – ySse1+Hsc70 <br />
+
**[[3c7n]], [[3d2e]], [[3d2f]] – ySse1+Hsc70 <br />
**[[2qxl]] – ySse1<br />
**[[2qxl]] – ySse1<br />
**[[2llv]] – ySti1 domain 1 – NMR<br />
**[[2llv]] – ySti1 domain 1 – NMR<br />
Line 383: Line 437:
**[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br />
**[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br />
**[[3uq3]] - ySti1 TPR repeats 4-9 + peptide<br />
**[[3uq3]] - ySti1 TPR repeats 4-9 + peptide<br />
-
**[[3lca]] – ySsa1 lid +yTOM71<br />
+
**[[5z8i]], [[5z8q]] – ySsa1 SBD - NMR<br />
-
**[[5z8q]], [[5z8i]] – ySsa1 SBD - NMR<br />
+
 
 +
*HspA5 or Grp78 or Endoplasmic reticulum chaperone BIP or 78 kDa glucose-related protein; Domains – NBD 26-407; SBD 418-637
 +
 
 +
**[[3ldn]] – hHspA5 NBD<br />
 +
**[[5e85]] – hHspA5 SBD domain <br />
 +
**[[5ex5]], [[5exw]], [[5ey4]] – hHspA5 + ATP analog<br />
 +
**[[3ldl]], [[5e84]], [[5f1x]], [[6asy]] – hHspA5 + ATP<br />
 +
**[[3iuc]], [[5evz]], [[5f0x]] – hHspA5 + ADP derivative<br />
 +
**[[5f2r]] – hHspA5 + ACP<br />
 +
**[[3ldo]] – hHspA5 + ANP<br />
 +
**[[3ldp]] – hHspA5 + inhibitor<br />
 +
**[[6cz1]], [[6dfm]], [[6dfo]], [[6do2]], [[6dws]] – hHspA5 + adenosine derivative<br />
 +
**[[6zmd]] – hHspA5 + FICD + ANP <br />
 +
**[[6eob]], [[6eoc]], [[7a4u]] – haHspA5 28-549 <br />
 +
**[[6hab]] – haHspA5 (mutant)<br />
 +
**[[5e86]] – haHspA5 SBD <br />
 +
**[[6zyh]], [[7a4v]] – haHspA5 + ADP <br />
 +
**[[5o4p]] – haHspA5 + AMP<br />
 +
**[[6eof]] – haHspA5 + AMP + ADP<br />
 +
**[[6eoe]] – haHspA5 + ADP<br />
 +
**[[7b7z]], [[7b80]] – haHspA5 + FICD + AMP <br />
 +
**[[6h9u]], [[6ha7]] – haHspA5 NBD + MANF<br />
*HspQ
*HspQ
**[[5ycq]] – EcHspQ<br />
**[[5ycq]] – EcHspQ<br />
 +
 +
*Hsp DegP or Periplasmic serine endoprotease DegP; Domains PDZ1 38-385; PDZ2 400-474
 +
 +
**[[3mh4]] – EcDegP <br />
 +
**[[1ky9]] – EcDegP (mutant) <br />
 +
**[[8f0a]], [[8f0u]], [[8f1t]], [[8f1u]], [[8f21]] – EcDegP + telomeric repeat-binding factor peptide – Cryo EM<br />
 +
**[[2zle]], [[4a8d]] – EcDegP + OmpC – Cryo EM<br />
 +
**[[3cs0]], [[3mh5]], [[3mh6]], [[3mh7]], [[3ou0]], [[6jjk]], [[6jjl]], [[6jjo]] – EcDegP + peptide <br />
 +
**[[3otp]] – EcDegP + lysozyme <br />
*'''Heat shock cognate protein (Hsc)'''
*'''Heat shock cognate protein (Hsc)'''
-
*''Hsc70''
+
*''Hsc20''
 +
 
 +
**[[3bvo]] - hHsc20<br />
 +
 
 +
*''Hsc70; NBD 1-394; SBD 395-544''
**[[3fzf]] - hHsc70 NBD+BAG domain regulator protein+ATP<br />
**[[3fzf]] - hHsc70 NBD+BAG domain regulator protein+ATP<br />
Line 398: Line 486:
**[[3fzk]], [[3fzl]] - hHsc70 NBD+BAG domain regulator protein+ purine derivative<br />
**[[3fzk]], [[3fzl]] - hHsc70 NBD+BAG domain regulator protein+ purine derivative<br />
**[[4h5n]], [[4h5r]], [[4h5v]], [[4h5w]] - hHsc70 NBD<br />
**[[4h5n]], [[4h5r]], [[4h5v]], [[4h5w]] - hHsc70 NBD<br />
-
**[[4h5t]] - hHsc70 NBD + ADP<br />
+
**[[4h5t]], [[6zyj]] - hHsc70 NBD + ADP<br />
-
**[[4hwi]], [[5aqf]], [[5aqg]], [[5aqh]], [[5aqi]], [[5aqj]], [[5aqgk]], [[5aql]], [[5aqm]], [[5aqn]], [[5aqo]], [[5aqp]], [[5aqq]], [[5aqr]], [[5aqs]], [[5aqt]], [[5aqu]], [[5aqv]] - hHsc70 NBD+BAG domain regulator protein<br />
+
**[[4hwi]], [[5aqf]], [[5aqg]], [[5aqh]], [[5aqi]], [[5aqj]], [[5aqk]], [[5aql]], [[5aqm]], [[5aqn]], [[5aqo]], [[5aqp]], [[5aqq]], [[5aqr]], [[5aqs]], [[5aqt]], [[5aqu]], [[5aqv]] - hHsc70 NBD+BAG domain regulator protein<br />
**[[2qw9]] – bHsc70 NBD – bovine<br />
**[[2qw9]] – bHsc70 NBD – bovine<br />
-
**[[2bup]], [[1bup]], [[1qqm]], [[1qqn]], [[1qqo]] - bHsc70 NBD (mutant)<br />
+
**[[1bup]], [[1qqm]], [[1qqn]], [[1qqo]], [[2bup]] - bHsc70 NBD (mutant)<br />
-
**[[4fl9]], [[1yuw]] - bHsp70 NBD + SBD<br />
+
**[[1yuw]], [[4fl9]] - bHsp70 NBD + SBD<br />
-
**[[2qwl]], [[2qwm]], [[1atr]], [[1ats]], [[1hpm]], [[1nga]], [[1ngb]], [[1ngc]], [[1ngd]], [[3hsc]] - bHsc70 NBD+ADP<br />
+
**[[7o6r]], [[7odb]], [[7odd]], [[7odi]], [[7plk]] - bHsp70 NBD + SBD (mutant) + inhibitor<br />
 +
**[[1atr]], [[1ats]], [[1hpm]], [[1nga]], [[1ngb]], [[1ngc]], [[1ngd]], [[2qwl]], [[2qwm]], [[3hsc]] - bHsc70 NBD+ADP<br />
**[[2qwn]], [[2qwo]], [[2qwp]], [[2qwq]], [[2qwr]] - bHsc70 NBD (mutant)+ auxilin protein<br />
**[[2qwn]], [[2qwo]], [[2qwp]], [[2qwq]], [[2qwr]] - bHsc70 NBD (mutant)+ auxilin protein<br />
**[[1ba0]], [[1ba1]] – bHsc70 NBD (mutant) + ADP<br />
**[[1ba0]], [[1ba1]] – bHsc70 NBD (mutant) + ADP<br />
Line 411: Line 500:
**[[1hx1]] - bHsc70 NBD + molecular chaperone regulator 1 BAG domain<br />
**[[1hx1]] - bHsc70 NBD + molecular chaperone regulator 1 BAG domain<br />
**[[2v7z]] – rHsc70 NBD + SBD – rat<br />
**[[2v7z]] – rHsc70 NBD + SBD – rat<br />
-
**[[7hsc]], [[1ckr]] - rHsc70 sub - NMR<br />
+
**[[1ckr]], [[7hsc]] - rHsc70 sub - NMR<br />
-
**[[3cqx]] - Hsc70 NBD+BAG domain regulator protein – mouse<br />
+
 
 +
**[[3cqx]] - Hsc70 NBD+BAG domain regulator protein <br />
 +
 
 +
*''Hsc82''
 +
 
 +
**[[6xlc]] - yHsc82 + ANP<br />
 +
**[[6xlh]] - yHsc82 MD+co-chaperone AHA1 + ADP + ATPgS<br />
 +
**[[6xld]], [[6xle]], [[6xlf]] - yHsc82 MD+co-chaperone AHA1 + ANP <br />
 +
**[[6xlb]] - yHsc82 MD+co-chaperone AHA1 + ANP – Cryo EM<br />
 +
**[[6xlg]] - yHsc82 MD+co-chaperone AHA1 + ATPgS<br />
*''Hsc90''
*''Hsc90''
-
**[[4xkk]], [[4xe2]], [[4xka]], [[4xko]] – smHsc90 NTD – slime mold<br />
+
**[[4xe2]], [[4xka]], [[4xkk]], [[4xko]] – smHsc90 NTD – slime mold<br />
-
**[[4xcj]], [[4xc0]], [[4xcl]], [[4xd8]] – smHsc90 NTD + nucleotide<br />
+
**[[4xc0]], [[4xcj]], [[4xcl]], [[4xd8]] – smHsc90 NTD + nucleotide<br />
**[[4xdm]] – smHsc90 NTD + antibiotic<br />
**[[4xdm]] – smHsc90 NTD + antibiotic<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Heat Shock Proteins

Updated on 11-August-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky

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