1wdc

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[[Image:1wdc.gif|left|200px]]
[[Image:1wdc.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1wdc", creates the "Structure Box" on the page.
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wdc OCA], [http://www.ebi.ac.uk/pdbsum/1wdc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wdc RCSB]</span>
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'''SCALLOP MYOSIN REGULATORY DOMAIN'''
'''SCALLOP MYOSIN REGULATORY DOMAIN'''
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[[Category: Cohen, C.]]
[[Category: Cohen, C.]]
[[Category: Houdusse, A.]]
[[Category: Houdusse, A.]]
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[[Category: calcium binding protein]]
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[[Category: Calcium binding protein]]
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[[Category: muscle protein]]
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[[Category: Muscle protein]]
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[[Category: myosin]]
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[[Category: Myosin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:29:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:34:42 2008''
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Revision as of 10:29, 3 May 2008

Image:1wdc.gif

Template:STRUCTURE 1wdc

SCALLOP MYOSIN REGULATORY DOMAIN


Overview

BACKGROUND: In contrast to the myosins of vertebrate skeletal muscle, molluscan myosins are regulated molecules whose enzymatic activity is switched on by the direct binding of Ca2+. The head portion (S1) of the molecule consists of a motor domain and a regulatory domain (RD) containing a 'regulatory' and an 'essential' light chain (RLC and ELC, respectively). The structures of scallop myosin RD with bound Ca2+, as well as the S1 fragment of chicken skeletal muscle myosin, have been determined previously to 2.8 A resolution. RESULTS: We have determined the structure at 2.0 A resolution of scallop myosin RD with bound Ca2+. The unusual coordination at the specific Ca(2+)-binding site in the ELC has now been clarified, as has the structural basis for Mg2+ binding to the RLC. A comparison of the scallop RD structure with that in the chicken S1 structure shows differences in the bending of the two RDs in two different places. CONCLUSIONS: Based on these structural results, a model for regulation is proposed in which the Ca(2+)-bound RD is a rigid structure, and transient flexibility of the Ca(2+)-free RD allows the myosin heads to make stabilizing intramolecular linkage which shut off the motor.

About this Structure

1WDC is a Protein complex structure of sequences from Argopecten irradians. Full crystallographic information is available from OCA.

Reference

Structure of the regulatory domain of scallop myosin at 2 A resolution: implications for regulation., Houdusse A, Cohen C, Structure. 1996 Jan 15;4(1):21-32. PMID:8805510 Page seeded by OCA on Sat May 3 13:29:56 2008

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