Histone methyltransferase 3D structures

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== 3D Structures of histone methyltransferase ==
== 3D Structures of histone methyltransferase ==
Line 13: Line 12:
**[[2igq]] – hHMT-1 C terminal
**[[2igq]] – hHMT-1 C terminal
-
*Histone-lysine N-methyltransferase; Domains – Tudor 190-410
+
*Histone-lysine N-methyltransferase; Domains – Tudor 190-410; CxxC or zinc finger 1146-1214
**[[3s8s]] – hKHMT SETD1A RRM domain<br />
**[[3s8s]] – hKHMT SETD1A RRM domain<br />
Line 26: Line 25:
**[[1h3i]] - hKHMT SET7/9 residues 52-344<br />
**[[1h3i]] - hKHMT SET7/9 residues 52-344<br />
**[[2o8j]] - hKHMT H3K9 residues 913-1193<br />
**[[2o8j]] - hKHMT H3K9 residues 913-1193<br />
 +
**[[2j2s]] – Mll1 CxxC domain - NMR<br />
**[[5f5e]] – Mll1 residues 3813-3969<br />
**[[5f5e]] – Mll1 residues 3813-3969<br />
**[[5f59]] – Mll3 residues 4757-4910<br />
**[[5f59]] – Mll3 residues 4757-4910<br />
Line 31: Line 31:
**[[5ht6]] - Mll5 residues 323-458<br />
**[[5ht6]] - Mll5 residues 323-458<br />
**[[2kyu]] - hKHMT Mll Phd3 finger – NMR<br />
**[[2kyu]] - hKHMT Mll Phd3 finger – NMR<br />
-
**[[6g3t]], [[6g3p]] - hKHMT Nsd3 residues 247-398<br />
+
**[[6g3p]], [[6g3t]] - hKHMT Nsd3 residues 247-398<br />
**[[4gnd]] - hKHMT Nsd3 Phd5-C5HCH 1310-1413<br />
**[[4gnd]] - hKHMT Nsd3 Phd5-C5HCH 1310-1413<br />
**[[4rxj]] - hKHMT Nsd3 residues 953-1064<br />
**[[4rxj]] - hKHMT Nsd3 residues 953-1064<br />
Line 40: Line 40:
**[[3k9j]], [[3k9k]] – hKHMT Setmar transposable domain (mutant)<br />
**[[3k9j]], [[3k9k]] – hKHMT Setmar transposable domain (mutant)<br />
**[[3n71]] - hKHMT Smyd1<br />
**[[3n71]] - hKHMT Smyd1<br />
 +
**[[9ckf]], [[9ckg]] - hKHMT Smyd2 (mutant)<br />
**[[5hi7]] - hKHMT Smyd3<br />
**[[5hi7]] - hKHMT Smyd3<br />
**[[3rsn]], [[3s32]] – hKHMT Ash2 N terminal<br />
**[[3rsn]], [[3s32]] – hKHMT Ash2 N terminal<br />
Line 52: Line 53:
**[[2j8a]] – KHMT SET1 RRM domain – yeast<br />
**[[2j8a]] – KHMT SET1 RRM domain – yeast<br />
**[[1u2z]] – yKHMT C terminal<br />
**[[1u2z]] – yKHMT C terminal<br />
 +
**[[5h6z]], [[5ww0]] - KHMT SET7 – fission yeast <br />
**[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
**[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
**[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
**[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
Line 64: Line 66:
**[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain + DNA <br />
**[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain + DNA <br />
**[[5vc8]] - hKHMT Nsd2 + DNA<br />
**[[5vc8]] - hKHMT Nsd2 + DNA<br />
-
**[[5ei9]], [[5eh2]], [[5egb]] - hKHMT Prdm9 zinc finger domain + DNA<br />
+
**[[5egb]], [[5eh2]], [[5ei9]] - hKHMT Prdm9 zinc finger domain + DNA<br />
**[[4ygi]] – AtKHMT Suvh4 + DNA<br />
**[[4ygi]] – AtKHMT Suvh4 + DNA<br />
**[[6a5n]] – AtKHMT Suvh6 + DNA<br />
**[[6a5n]] – AtKHMT Suvh6 + DNA<br />
Line 73: Line 75:
**[[3qow]] – hKHMT + SAM <br />
**[[3qow]] – hKHMT + SAM <br />
**[[4ynm]] – hKHMT Ash1L + SAM <br />
**[[4ynm]] – hKHMT Ash1L + SAM <br />
-
**[[4ypu]], [[4ype]], [[4ypa]], [[4ynp]] – hKHMT Ash1L (mutant) + SAM <br />
+
**[[4ynp]], [[4ypa]], [[4ype]], [[4ypu]] – hKHMT Ash1L (mutant) + SAM <br />
**[[4h12]], [[5jle]] – hKHMT SETD2 catalytic domain + SAH <br />
**[[4h12]], [[5jle]] – hKHMT SETD2 catalytic domain + SAH <br />
**[[3smt]] – hKHMT SETD3 + SAM <br />
**[[3smt]] – hKHMT SETD3 + SAM <br />
Line 89: Line 91:
*Histone-lysine N-methyltransferase binary complexes with inhibitor
*Histone-lysine N-methyltransferase binary complexes with inhibitor
-
**[[5mw4]], [[5mw3]], [[5mvs]], [[5juw]], [[5dtr]], [[5dtq]], [[5dtm]], [[5dt2]], [[5dsx]], [[5dry]], [[5drt]], [[4wvl]] – hKHMT DOT1L + inhibitor <br />
 
-
**[[4fmu]], [[5lt8]], [[5lt7]], [[5lt6]], [[5lsz]], [[5lsy]], [[5lsx]], [[5lsu]], [[5lss]] – hKHMT SETD2 + inhibitor <br />
 
-
**[[5th7]] – hKHMT SETD8 + inhibitor <br />
 
-
**[[5t5g]] – hKHMT SETD8 (mutant) + inhibitor <br />
 
-
**[[5ke3]], [[5ke2]], [[5kco]], [[5kch]], [[6bpi]], [[6au3]], [[6au2]], [[7c9n]], [[7caj]], [[7cd9]], [[7cjt]] - hKHMT SETDB1 tudor domain + inhibitor<br />
 
**[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br />
**[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br />
-
**[[4wuy]], [[6cby]], [[6cbx]], [[5wcg]] - hKHMT Smyd2 + inhibitor<br />
+
**[[4wuy]], [[5wcg]], [[6cbx]], [[6cby]] - hKHMT Smyd2 + inhibitor<br />
**[[5cpr]] - hKHMT Suv420 SET domain + inhibitor<br />
**[[5cpr]] - hKHMT Suv420 SET domain + inhibitor<br />
**[[6p0r]] - hKHMT Suv39h2 SET domain + inhibitor<br />
**[[6p0r]] - hKHMT Suv39h2 SET domain + inhibitor<br />
**[[5w1y]], [[6boz]] - hKHMT KMT5A SET domain (mutant) + inhibitor<br />
**[[5w1y]], [[6boz]] - hKHMT KMT5A SET domain (mutant) + inhibitor<br />
**[[5wbv]] - hKHMT KMT5B SET domain + inhibitor<br />
**[[5wbv]] - hKHMT KMT5B SET domain + inhibitor<br />
-
**[[5vsf]], [[5vsd]], [[5vpj]] - hKHMT EHMT1 SET domain + inhibitor<br />
+
**[[5vpj]], [[5vsd]], [[5vsf]] - hKHMT EHMT1 SET domain + inhibitor<br />
-
**[[5vse]], [[5vsc]], [[5vpi]] - hKHMT EHMT2 SET domain + inhibitor<br />
+
**[[5vpi]], [[5vsc]], [[5vse]] - hKHMT EHMT2 SET domain + inhibitor<br />
**[[6nm4]] - hKHMT Prdm9 zinc finger domain + inhibitor<br />
**[[6nm4]] - hKHMT Prdm9 zinc finger domain + inhibitor<br />
**[[6ue6]], [[6xcg]] - hKHMT Nsd2 PWWP1 domain residues 211-350 + inhibitor<br />
**[[6ue6]], [[6xcg]] - hKHMT Nsd2 PWWP1 domain residues 211-350 + inhibitor<br />
-
**[[6g2o]], [[6g2f]], [[6g2e]], [[6g2c]], [[6g2b]], [[6g29]], [[6g27]], [[6g25]], [[6g24]] - hKHMT Nsd3 residues 247-398 + inhibitor<br />
+
**[[6g24]], [[6g25]], [[6g27]], [[6g29]], [[6g2b]], [[6g2c]], [[6g2e]], [[6g2f]], [[6g2o]] - hKHMT Nsd3 residues 247-398 + inhibitor<br />
**[[6u9k]], [[6u9m]], [[6u9n]], [[6u9r]] - hKHMT MLL1 SET 167-333 (mutant) + inhibitor<br />
**[[6u9k]], [[6u9m]], [[6u9n]], [[6u9r]] - hKHMT MLL1 SET 167-333 (mutant) + inhibitor<br />
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**[[4gne]], [[4gnf]], [[4gng]] - hKHMT Nsd3 Phd5-C5HCH + H3 peptide<br />
**[[4gne]], [[4gnf]], [[4gng]] - hKHMT Nsd3 Phd5-C5HCH + H3 peptide<br />
**[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br />
**[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br />
-
**[[6bhi]], [[6bhh]], [[6bhg]], [[6bhe]], [[6bhd]] - hKHMT SETDB1 tudor domain + H3 peptide<br />
+
**[[6bhd]], [[6bhe]], [[6bhg]], [[6bhh]], [[6bhi]] - hKHMT SETDB1 tudor domain + H3 peptide<br />
**[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br />
**[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br />
**[[6mlc]] - hKHMT Mll3 Phd7 domain + H4 peptide <br />
**[[6mlc]] - hKHMT Mll3 Phd7 domain + H4 peptide <br />
**[[6o7g]] - hKHMT Mll4 Phd6 domain + H4 peptide - NMR<br />
**[[6o7g]] - hKHMT Mll4 Phd6 domain + H4 peptide - NMR<br />
-
**[[5ex3]], [[5ex0]] - hKHMT Smyd3 + peptide<br />
+
**[[9ckc]] - hKHMT Smyd2 + peptide<br />
 +
**[[5ex0]], [[5ex3]] - hKHMT Smyd3 + peptide<br />
**[[5yvx]] - hKHMT Ashh2 CW domain + H3 peptide<br />
**[[5yvx]] - hKHMT Ashh2 CW domain + H3 peptide<br />
-
**[[6hbo]], [[6qxz]] - hKHMT Ashh2 CW domain + H3 peptide - NMR<br />
+
**[[6qxz]] - hKHMT Ashh2 CW domain + H3 peptide - NMR<br />
**[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br />
**[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br />
**[[6cko]] - zKHMT + AF-10 - zebrafish<br />
**[[6cko]] - zKHMT + AF-10 - zebrafish<br />
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**[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
**[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
**[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br />
**[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br />
-
**[[6e2h]] – hKHMT SET/Ash2 + DPY-30L <br />
+
**[[4riq]], [[6e2h]] – hKHMT SET/Ash2 + DPY-30L <br />
**[[6u4y]] - hKHMT Ezh2 + polycomb protein EED<br />
**[[6u4y]] - hKHMT Ezh2 + polycomb protein EED<br />
**[[6jn2]] – hKHMT4 coiled-coil domain 470-550 + AF-10<br />
**[[6jn2]] – hKHMT4 coiled-coil domain 470-550 + AF-10<br />
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**[[2w5z]] – hKHMT Hrx methyltransferase domain + SAH + histone peptide<br />
**[[2w5z]] – hKHMT Hrx methyltransferase domain + SAH + histone peptide<br />
-
**[[5v22]], [[5v21]], [[5jlb]], [[5jjy]] - hKHMT SETD2 catalytic domain 1434-1711 + SAH + H3 peptide<br />
+
**[[5jjy]], [[5jlb]] [[5v21]], [[5v22]] - hKHMT SETD2 catalytic domain 1434-1711 + SAH + H3 peptide<br />
**[[6vdb]] - hKHMT SETD2 catalytic domain + SAH + peptide<br />
**[[6vdb]] - hKHMT SETD2 catalytic domain + SAH + peptide<br />
**[[6jat]], [[6ox0]], [[6ox1]], [[6ox2]], [[6ox3]], [[6ox4]], [[6ox5]] - hKHMT SETD3 + sinefungin + actin peptide<br />
**[[6jat]], [[6ox0]], [[6ox1]], [[6ox2]], [[6ox3]], [[6ox4]], [[6ox5]] - hKHMT SETD3 + sinefungin + actin peptide<br />
Line 147: Line 145:
**[[5eg2]] - hKHMT SETD7 SET domain + SAH + TAF10 peptide<br />
**[[5eg2]] - hKHMT SETD7 SET domain + SAH + TAF10 peptide<br />
**[[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br />
**[[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br />
-
**[[4j7i]], [[4j83]], [[4j8o]], [[4j7f]] - hKHMT SETD7 + SAH + TFIID peptide<br />
+
**[[4j7f]], [[4j7i]], [[4j83]], [[4j8o]] - hKHMT SETD7 + SAH + TFIID peptide<br />
**[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br />
**[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br />
**[[1xqh]] - hKHMT SET7/9 SET domain + SAH + p53 peptide<br />
**[[1xqh]] - hKHMT SET7/9 SET domain + SAH + p53 peptide<br />
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**[[3os5]] - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide<br />
**[[3os5]] - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide<br />
**[[3qxy]], [[3rc0]] - hKHMT SETD6 SET domain + p65 peptide + SAM<br />
**[[3qxy]], [[3rc0]] - hKHMT SETD6 SET domain + p65 peptide + SAM<br />
-
**[[5jj0]], [[5jiy]], [[5jin]], [[5jhn]] - hKHMT EHMT2 SET domain + SAM + H3 peptide<br />
+
**[[5jhn]], [[5jin]], [[5jiy]], [[5jj0]] - hKHMT EHMT2 SET domain + SAM + H3 peptide<br />
**[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br />
**[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br />
**[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br />
**[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br />
Line 163: Line 161:
**[[6o9o]], [[6p6g]] – hKHMT Smyd3 + SAH + inhibitor<br />
**[[6o9o]], [[6p6g]] – hKHMT Smyd3 + SAH + inhibitor<br />
**[[5hq8]] – hKHMT Smyd3 + SAH + MEKK2 peptide<br />
**[[5hq8]] – hKHMT Smyd3 + SAH + MEKK2 peptide<br />
-
**[[6ine]], [[6ago]] – hKHMT Ash1L + MRG15 + SAM <br />
+
**[[6ago]], [[6ine]] – hKHMT Ash1L + MRG15 + SAM <br />
**[[1zkk]] - hKHMT + SAH + H4 peptide <br />
**[[1zkk]] - hKHMT + SAH + H4 peptide <br />
**[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />
**[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />
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**[[6cen]] - hKHMT Nsd3 + inhibitor peptide + SAM<br />
**[[6cen]] - hKHMT Nsd3 + inhibitor peptide + SAM<br />
**[[7bre]] – hKHMT Mll1 + RBBP5 + Ash2L<br />
**[[7bre]] – hKHMT Mll1 + RBBP5 + Ash2L<br />
-
**[[5f6l]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br />
+
**[[5f6l]], [[7w67]], [[7w6a]], [[7w6i]], [[7w6j]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br />
**[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br />
**[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br />
**[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br />
**[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br />
Line 181: Line 179:
**[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br />
**[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br />
**[[7lzb]], [[7lzd]], [[7lzf]] - hKHMT SETD2 catalytic domain 1434-1711 + SAH + inhibitor<br />
**[[7lzb]], [[7lzd]], [[7lzf]] - hKHMT SETD2 catalytic domain 1434-1711 + SAH + inhibitor<br />
-
**[[5tuz]], [[6mbp]], [[6mbo]] - hKHMT EHMT1 SET domain + SAH + inhibitor<br />
+
**[[5tuz]], [[6mbo]], [[6mbp]] - hKHMT EHMT1 SET domain + SAH + inhibitor<br />
**[[5ttg]], [[5v9j]] - hKHMT EHMT1 catalytic domain + SAM + inhibitor<br />
**[[5ttg]], [[5v9j]] - hKHMT EHMT1 catalytic domain + SAM + inhibitor<br />
**[[5tuy]], [[5v9i]], [[7btv]], [[7buc]], [[7dcf]] - hKHMT EHMT2 SET domain + SAM + inhibitor<br />
**[[5tuy]], [[5v9i]], [[7btv]], [[7buc]], [[7dcf]] - hKHMT EHMT2 SET domain + SAM + inhibitor<br />
**[[5ttf]] - hKHMT EHMT2 catalytic domain + SAM + inhibitor<br />
**[[5ttf]] - hKHMT EHMT2 catalytic domain + SAM + inhibitor<br />
-
**[[3s7b]], [[5kjn]], [[5kjm]], [[5kjl]], [[5kjk]], [[5arg]], [[5arf]], [[4ynd]] - hKHMT Smyd2 + SAM + inhibitor<br />
+
**[[3s7b]], [[4ynd]], [[5arf]], [[5arg]], [[5kjk]], [[5kjl]], [[5kjm]], [[5kjn]] - hKHMT Smyd2 + SAM + inhibitor<br />
**[[6mon]] - hKHMT Smyd2 + SAH + inhibitor peptide<br />
**[[6mon]] - hKHMT Smyd2 + SAH + inhibitor peptide<br />
-
**[[5ccm]], [[5ccl]], [[5yjo]], [[5xxj]], [[5xxg]], [[5xxd]], [[6ijl]] – hKHMT Smyd3 + SAM + inhibitor<br />
+
**[[5ccl]], [[5ccm]], [[5xxd]], [[5xxg]], [[5xxj]], [[5yjo]], [[6ijl]] – hKHMT Smyd3 + SAM + inhibitor<br />
**[[1zkk]] - hKHMT + SAH + H4 peptide <br />
**[[1zkk]] - hKHMT + SAH + H4 peptide <br />
**[[6in3]] – hKHMT DOT1L + SAH + inhibitor <br />
**[[6in3]] – hKHMT DOT1L + SAH + inhibitor <br />
Line 202: Line 200:
**[[5hq2]] - hKHMT SETD8 SET domain + H3 + H4 + H2 + SRM1 + DNA<br />
**[[5hq2]] - hKHMT SETD8 SET domain + H3 + H4 + H2 + SRM1 + DNA<br />
**[[6jm9]] - hKHMT DOT1 + H3.2 + H4 + H2A + H2B + DNA – Cryo EM<br />
**[[6jm9]] - hKHMT DOT1 + H3.2 + H4 + H2A + H2B + DNA – Cryo EM<br />
-
**[[6o96]], [[6nqa]], [[6nog]], [[6nn6]], [[6nj9]], [[6jm9]], [[6jma]], [[6j99]], [[7bwd]], [[7k6p]], [[7k6q]] - hKHMT DOT1 in nucleosome – Cryo EM<br />
+
**[[6j99]], [[6jm9]], [[6jma]], [[6nj9]], [[6nn6]], [[6nog]], [[6nqa]], [[6o96]], [[7bwd]], [[7k6p]], [[7k6q]] - hKHMT DOT1 in nucleosome – Cryo EM<br />
**[[7cro]] - hKHMT Nsd2 in nucleosome – Cryo EM<br />
**[[7cro]] - hKHMT Nsd2 in nucleosome – Cryo EM<br />
**[[7crr]] - hKHMT Nsd3 in nucleosome – Cryo EM<br />
**[[7crr]] - hKHMT Nsd3 in nucleosome – Cryo EM<br />
**[[7crp]], [[7crq]] - hKHMT Nsd3 (mutant) in nucleosome – Cryo EM<br />
**[[7crp]], [[7crq]] - hKHMT Nsd3 (mutant) in nucleosome – Cryo EM<br />
-
**[[5t0m]], [[5t0k]] - hKHMT EHMT2 SET domain + SAM + SAH + H3 peptide<br />
+
**[[6w5i]], [[6w5m]], [[6w5n]] – hKHMT Ash2L in nucleosome – Cryo EM<br />
-
**[[5ls6]], [[5hyn]] - hKHMT Ezh2in+ polycomb complex + inhibitor<br />
+
**[[7xpx]] – hKHMT SET8 in nucleosome – Cryo EM<br />
-
**[[6c24]], [[6c23]], [[6wkr]] - hKHMT Ezh2 in polycomb complex – Cryo EM<br />
+
**[[7mbm]], [[7mbn]], [[7ud5]] – hKHMT MLL1 in nucleosome – Cryo EM<br />
-
**[[7kso]], [[7ktp]], [[7ksr]] - hKHMT Ezh1 in polycomb complex – Cryo EM<br />
+
**[[5t0k]], [[5t0m]] - hKHMT EHMT2 SET domain + SAM + SAH + H3 peptide<br />
 +
**[[5hyn]], [[5ls6]] - hKHMT Ezh2in+ polycomb complex + inhibitor<br />
 +
**[[6c23]], [[6c24]], [[6wkr]] - hKHMT Ezh2 in polycomb complex – Cryo EM<br />
 +
**[[7kso]], [[7ksr]], [[7ktp]] - hKHMT Ezh1 in polycomb complex – Cryo EM<br />
**[[6pwv]] - hKHMT 2A + MLL1 complex – Cryo EM<br />
**[[6pwv]] - hKHMT 2A + MLL1 complex – Cryo EM<br />
**[[6pww]] - hKHMT 2A + MLL1 complex + RBPP5 + WDR5 – Cryo EM<br />
**[[6pww]] - hKHMT 2A + MLL1 complex + RBPP5 + WDR5 – Cryo EM<br />
Line 238: Line 239:
**[[7boc]] – hPRMT5 TIM barrel domain 1-292 + peptide<br />
**[[7boc]] – hPRMT5 TIM barrel domain 1-292 + peptide<br />
**[[6ugh]] – hPRMT5 + MEP50 – Cryo EM<br />
**[[6ugh]] – hPRMT5 + MEP50 – Cryo EM<br />
-
**[[5egs]], [[5wcf]], [[5lv5]], [[5lv4]], [[5lv3]], [[5lv2]] – hPRMT6 + inhibitor<br />
+
**[[5egs]], [[5lv2]], [[5lv3]], [[5lv4]], [[5lv5]], [[5wcf]] – hPRMT6 + inhibitor<br />
 +
**[[5dst]] – hPRMT8 catalytic domain + SAH<br />
**[[5ih3]] – mPRMT4 + SAH<br />
**[[5ih3]] – mPRMT4 + SAH<br />
-
**[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]], [[5tbj]], [[5tbi]], [[5tbh]], [[5ntc]], [[5lkj]], [[5k8x]], [[5k8w]] – mPRMT4 + inhibitor<br />
+
**[[5isi]], [[5is6]], [[5is7]], [[5is8]], [[5is9]], [[5isa]], [[5isb]], [[5isc]], [[5isd]], [[5ise]], [[5isf]], [[5isg]], [[5ish]], [[5k8v]], [[5k8w]], [[5k8x]], [[5lkj]], [[5ntc]], [[5tbh]], [[5tbi]], [[5tbj]] – mPRMT4 + inhibitor<br />
-
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT4 + poly(A)-binding protein peptide + inhibitor<br />
+
**[[5lgp]], [[5lgq]], [[5lgr]], [[5lgs]] – mPRMT4 + poly(A)-binding protein peptide + inhibitor<br />
-
**[[4c04]], [[6sq3]], [[6sq4]] – mPRMT6 + inhibitor<br />
+
**[[4c04]], [[6sq3]], [[6sq4]], [[7nud]], [[7nue]], [[7p2r]], [[7ppq]], [[7ppy]], [[7pu8]], [[7puc]], [[7puq]], [[7pv6]] – mPRMT 6 + inhibitor<br />
-
**[[4c05]], [[5fqo]], [[5fqn]] – mPRMT6 + SAH<br />
+
**[[6sqk]] – mPRMT 6 + peptide<br />
 +
**[[7os4]] – mPRMT 6 + histone H3.1<br />
 +
**[[7okp]] – mPRMT 6 + histone H3.3<br />
 +
**[[4c05]], [[5fqn]], [[5fqo]] – mPRMT6 + SAH<br />
**[[4c4a]] – mPRMT7 + SAH<br />
**[[4c4a]] – mPRMT7 + SAH<br />
**[[6ogn]] – mPRMT7 + inhibitor<br />
**[[6ogn]] – mPRMT7 + inhibitor<br />
Line 252: Line 257:
*Histone-arginine N-methyltransferase (Carm1) ternary complex
*Histone-arginine N-methyltransferase (Carm1) ternary complex
-
**[[5dxa]], [[5dx8]], [[5dx1]] – hPRMT4 catalytic domain + sinefungin + peptide<br />
+
**[[5dx1]], [[5dx8]], [[5dxa]] – hPRMT4 catalytic domain + sinefungin + peptide<br />
-
**[[5dx0]], [[5dwq]] – hPRMT4 catalytic domain + sinefungin + H3 peptide<br />
+
**[[5dwq]], [[5dx0]] – hPRMT4 catalytic domain + sinefungin + H3 peptide<br />
**[[2y1w]], [[2y1x]] – hPRMT4 catalytic domain + sinefungin + indole inhibitor<br />
**[[2y1w]], [[2y1x]] – hPRMT4 catalytic domain + sinefungin + indole inhibitor<br />
-
**[[6arv]], [[6arj]] – hPRMT4 catalytic domain + SAH + inhibitor<br />
+
**[[6arj]], [[6arv]] – hPRMT4 catalytic domain + SAH + inhibitor<br />
**[[6rll]], [[6rlq]], [[6uxx]], [[6uxy]] – hPRMT5 + MEP50 + inhibitor<br />
**[[6rll]], [[6rlq]], [[6uxx]], [[6uxy]] – hPRMT5 + MEP50 + inhibitor<br />
**[[7m05]] – hPRMT5 + MEP50 + inhibitor – Cryo EM<br />
**[[7m05]] – hPRMT5 + MEP50 + inhibitor – Cryo EM<br />
**[[6w6d]], [[6wad]], [[7nr4]] – hPRMT6 1-375 + SAH + inhibitor<br />
**[[6w6d]], [[6wad]], [[7nr4]] – hPRMT6 1-375 + SAH + inhibitor<br />
-
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT 4 + poly(A)-binding protein peptide + inhibitor<br />
+
**[[5lgp]], [[5lgq]], [[5lgr]], [[5lgs]] – mPRMT 4 + poly(A)-binding protein peptide + inhibitor<br />
**[[4gqb]], [[5fa5]] – hPRMT5 + MEP50 + H4 peptide<br />
**[[4gqb]], [[5fa5]] – hPRMT5 + MEP50 + H4 peptide<br />
**[[5emm]] – hPRMT5 + MEP50 + sinefungin<br />
**[[5emm]] – hPRMT5 + MEP50 + sinefungin<br />
**[[6k1s]], [[7kic]] – hPRMT5 + MEP50 + inhibitor<br />
**[[6k1s]], [[7kic]] – hPRMT5 + MEP50 + inhibitor<br />
**[[5eml]], [[7kib]], [[7l1g]] – hPRMT5 + MEP50 + SAM<br />
**[[5eml]], [[7kib]], [[7l1g]] – hPRMT5 + MEP50 + SAM<br />
-
**[[5emk]], [[5emj]], [[5c9z]] – hPRMT5 + MEP50 + sinefungin + inhibitor<br />
+
**[[5c9z]], [[5emj]], [[5emk]] – hPRMT5 + MEP50 + sinefungin + inhibitor<br />
**[[6v0n]], [[6v0o]] – hPRMT5 + MEP50 + sinefungin + peptide<br />
**[[6v0n]], [[6v0o]] – hPRMT5 + MEP50 + sinefungin + peptide<br />
-
**[[4x63]], [[4x61]], [[4x60]] – hPRMT5 + MEP50 + SAH + inhibitor<br />
+
**[[4x60]], [[4x61]], [[4x63]] – hPRMT5 + MEP50 + SAH + inhibitor<br />
**[[6ckc]], [[7kid]] – hPRMT5 + MEP50 + inhibitor<br />
**[[6ckc]], [[7kid]] – hPRMT5 + MEP50 + inhibitor<br />
-
**[[5e8r]], [[4y30]], [[4y2h]], [[6p7i]] – hPRMT6 + SAH + inhibitor<br />
+
**[[4y2h]], [[4y30]], [[5e8r]], [[6p7i]] – hPRMT6 + SAH + inhibitor<br />
**[[4qpp]] – hPRMT6 (mutant) + peptide + inhibitor<br />
**[[4qpp]] – hPRMT6 (mutant) + peptide + inhibitor<br />

Current revision

3D Structures of histone methyltransferase

Updated on 09-September-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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